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Chemical Structure| 1628317-18-9 Chemical Structure| 1628317-18-9

Structure of MI-463
CAS No.: 1628317-18-9

Chemical Structure| 1628317-18-9

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MI-463 is an effective inhibitor of themenin-MLL interaction.

Synonyms: MI-463

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Product Details of MI-463

CAS No. :1628317-18-9
Formula : C24H23F3N6S
M.W : 484.54
SMILES Code : N#CC(N1)=CC2=C1C=CC(CN3CCC(NC4=C(C=C(CC(F)(F)F)S5)C5=NC=N4)CC3)=C2C
Synonyms :
MI-463
MDL No. :MFCD28506301
InChI Key :DZACSLYTXLZAAF-UHFFFAOYSA-N
Pubchem ID :90455046

Safety of MI-463

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of MI-463

epigenetics

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
cynomolgus monkey primary hepatocytes 10 μM 300 minutes To determine the depletion rate of inhibitors in hepatocytes, results showed that cynomolgus monkey hepatocytes had the lowest metabolic activity for MI-463 Biomedicines. 2023 Feb 23;11(3):682
dog primary hepatocytes 10 μM 300 minutes To determine the depletion rate of inhibitors in hepatocytes, results showed that dog hepatocytes had lower metabolic activity for MI-463 Biomedicines. 2023 Feb 23;11(3):682
rat primary hepatocytes 10 μM 300 minutes To determine the depletion rate of inhibitors in hepatocytes, results showed that rat hepatocytes had the highest metabolic activity for MI-463 Biomedicines. 2023 Feb 23;11(3):682
beagle hepatic microsomes 50 µM 15 minutes Evaluated the effect of MI-463 on beagle CYP1A2 activity, no significant inhibition observed Vet Sci. 2022 Mar 23;9(4):156
rat hepatic microsomes 50 µM 15 minutes Evaluated the effect of MI-463 on rat CYP1A2 activity, showing significant inhibition (p=0.025) Vet Sci. 2022 Mar 23;9(4):156

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.06mL

0.41mL

0.21mL

10.32mL

2.06mL

1.03mL

20.64mL

4.13mL

2.06mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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