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Chemical Structure| 1208448-95-6 Chemical Structure| 1208448-95-6

Structure of MIF098
CAS No.: 1208448-95-6

Chemical Structure| 1208448-95-6

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MIF098 is a macrophage migration inhibitory factor (MIF) antagonist that inhibits the proliferation, migration, and fibrosis of lung smooth muscle cells, making it suitable for research on immune-inflammatory diseases.

4.5 *For Research Use Only !

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Product Details of MIF098

CAS No. :1208448-95-6
Formula : C15H13NO3
M.W : 255.27
SMILES Code : O=C1OC2=CC=C(C)C=C2N1CC3=CC=CC(O)=C3
MDL No. :MFCD23132494

Safety of MIF098

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
MIF098, a macrophage migration inhibitory factor (MIF) antagonist, inhibits proliferation, migration, and fibrosis in pulmonary smooth muscle cells and is applicable in immunoinflammation-related disease research[1].

In Vitro:

Cell Line
Concentration Treated Time Description References
human monocytes 20 μM 30 minutes MIF098 blocks MIF binding to its cognate receptor CD74, thereby suppressing IL-1β production and NLRP3 upregulation. Arthritis Rheumatol. 2019 Jan;71(1):109-120

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
UM-HET3 mice Genetically heterogeneous mice Dietary administration 240 ppm Starting at 8 months of age To test the effect of MIF098 on lifespan; results showed no significant effect on lifespan Aging Cell. 2021 May;20(5):e13328
Female C57BL/6 mice Persistent bladder pain model Intraperitoneal injection 40 mg/kg Twice daily from day 2 to day 8 MIF098 partially reversed PAR4-induced abdominal mechanical hypersensitivity Int J Urol. 2018 Oct;25(10):887-893
Mice Gao-Binge ethanol feeding model Intraperitoneal injection 60 mg/kg Administered at -18h and -1h before gavage, euthanized 6h after ethanol binge To investigate the effect of MIF098 on ethanol-induced liver injury, it was found that MIF098 reduced liver injury at 6h but exacerbated liver injury and UPR at 9h. Alcohol Clin Exp Res. 2019 Jul;43(7):1439-1451

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.59mL

3.92mL

1.96mL

39.17mL

7.83mL

3.92mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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