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Chemical Structure| 1398568-47-2 Chemical Structure| 1398568-47-2

Structure of Milademetan
CAS No.: 1398568-47-2

Chemical Structure| 1398568-47-2

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Milademetan is a specific MDM2 inhibitor with oral activity, primarily used in the study of acute myeloid leukemia and various solid tumors. It exerts anti-tumor effects by inducing G1 phase cell cycle arrest, senescence, and apoptosis.

Synonyms: DS-3032

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Product Details of Milademetan

CAS No. :1398568-47-2
Formula : C30H34Cl2FN5O4
M.W : 618.53
SMILES Code : CC1(C)CCC2([C@@]3(C(NC4=CC(Cl)=CC=C43)=O)[C@@H](C5=CC=NC(Cl)=C5F)[C@H](C(N[C@H]6CO[C@H](C(N)=O)CC6)=O)N2)CC1
Synonyms :
DS-3032
MDL No. :MFCD31692325

Safety of Milademetan

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03671564 Acute Myeloid Leukemia PHASE1 COMPLETED 2019-09-11 Japanese Red Cross Narita Hosp... More >>ital, Chiba, 286-0041, Japan|Kyusyu University Hospital, Fukuoka, 812-8582, Japan|Gifu Municipal Hospital, Gifu, 500-8513, Japan|Chugoku Central Hospital, Hiroshima, 720-0001, Japan|National Hospital Organization Kumamoto Medical Center, Kumamoto, 860-0008, Japan|Tenri Hospital, Nara, 632-8552, Japan|NTT Medical Center Tokyo, Tokyo, 141-8625, Japan|National Hospital Organization Disaster Medical Center, Tokyo, 190-0014, Japan Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.62mL

0.32mL

0.16mL

8.08mL

1.62mL

0.81mL

16.17mL

3.23mL

1.62mL

 

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