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Chemical Structure| 459-86-9 Chemical Structure| 459-86-9

Structure of Mitoguazone
CAS No.: 459-86-9

Chemical Structure| 459-86-9

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Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methioninedecarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation.

Synonyms: Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG

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Product Details of Mitoguazone

CAS No. :459-86-9
Formula : C5H12N8
M.W : 184.20
SMILES Code : CC(/C=N/NC(N)=N)=N\NC(N)=N
Synonyms :
Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG
MDL No. :MFCD00067519

Safety of Mitoguazone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00002348 Lymphoma, Non-Hodgkin|HIV Infe... More >>ctions Less << PHASE2 COMPLETED - ILEX Oncology Inc, San Antonio... More >>, Texas, 782453217, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.43mL

1.09mL

0.54mL

27.14mL

5.43mL

2.71mL

54.29mL

10.86mL

5.43mL

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