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Chemical Structure| 869363-13-3 Chemical Structure| 869363-13-3

Structure of MLN8054
CAS No.: 869363-13-3

Chemical Structure| 869363-13-3

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MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM and exhibits more than 40-fold selective for Aurora A than Aurora B.

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Product Details of MLN8054

CAS No. :869363-13-3
Formula : C25H15ClF2N4O2
M.W : 476.86
SMILES Code : O=C(O)C1=CC=C(NC2=NC=C3C(C4=CC=C(Cl)C=C4C(C5=C(F)C=CC=C5F)=NC3)=N2)C=C1
MDL No. :MFCD11840561
InChI Key :HHFBDROWDBDFBR-UHFFFAOYSA-N
Pubchem ID :11712649

Safety of MLN8054

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of MLN8054

epigenetics
DNA

Isoform Comparison

Biological Activity

Target
  • Aurora A

    Aurora A, IC50:4 nM

  • Aurora B

    Aurora B, IC50:172 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00249301 Breast Neoplasm|Colon Neoplasm... More >>|Pancreatic Neoplasm|Bladder Neoplasm Less << PHASE1 TERMINATED - The Sarah Cannon Research Inst... More >>itute, Nashville, Tennessee, 37203, United States Less <<
NCT00652158 Advanced Malignancies PHASE1 TERMINATED 2025-04-08 Ciutat Sanitaria Vall d'Hebron... More >>, Barcelona, 08035, Spain Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.49mL

2.10mL

1.05mL

20.97mL

4.19mL

2.10mL

References

 

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