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Chemical Structure| 1832576-04-1 Chemical Structure| 1832576-04-1

Structure of MLT-943
CAS No.: 1832576-04-1

Chemical Structure| 1832576-04-1

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MLT-943 is a highly effective, selective MALT1 protease inhibitor with good oral bioavailability. It effectively inhibits IL-2 secretion in PBMC and whole blood with IC50 values of 0.07-0.09 μM (PBMC) and 0.6-0.8 μM (whole blood), showing anti-inflammatory properties and is applicable in FcγR-mediated inflammation research.

4.5 *For Research Use Only !

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Product Details of MLT-943

CAS No. :1832576-04-1
Formula : C16H14ClF3N6O2
M.W : 414.77
SMILES Code : [C@H](OC)(C)C=1N2C(=CC(Cl)=N2)N=CC1NC(NC=3C=C(C(F)(F)F)N=CC3)=O
MDL No. :MFCD34368519

Safety of MLT-943

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
MLT-943 is a potent, selective, and orally active inhibitor of MALT1 protease. It inhibits stimulated IL-2 secretion in PBMC or whole blood with a consistent IC50 across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood). MLT-943 possesses anti-inflammatory properties and is suitable for research on FcγR-mediated inflammation[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.05mL

2.41mL

1.21mL

24.11mL

4.82mL

2.41mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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