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Chemical Structure| 352693-80-2 Chemical Structure| 352693-80-2

Structure of MMRi62
CAS No.: 352693-80-2

Chemical Structure| 352693-80-2

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MMRi62 is a ferroptosis inducer that effectively inhibits the MDM2-MDM4 interaction, promoting apoptosis in pancreatic ductal adenocarcinoma cells.

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Product Details of MMRi62

CAS No. :352693-80-2
Formula : C21H15Cl2N3O
M.W : 396.27
SMILES Code : OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(Cl)=C3Cl)NC4=NC=CC=C4
MDL No. :MFCD01647927

Safety of MMRi62

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HL60VR cells HL60VR cells MMRi62 inhibited HL60VR cell proliferation with an IC50 of 0.22 µM Front Oncol. 2022 Aug 5;12:933446.
SW1990 SW1990 MMRi62 shows no significant inhibitory effect on some PDAC cell lines Mol Cancer Ther. 2022 Apr 1;21(4):535-545.
Capan2 Capan2 MMRi62 inhibits PDAC cell proliferation Mol Cancer Ther. 2022 Apr 1;21(4):535-545.
AsPc1 AsPc1 MMRi62 inhibits PDAC cell proliferation Mol Cancer Ther. 2022 Apr 1;21(4):535-545.
HL60 cells HL60 cells MMRi62 inhibited HL60 cell proliferation with an IC50 of 0.34 µM Front Oncol. 2022 Aug 5;12:933446.
NALM6 cells NALM6 cells MMRi62 inhibited NALM6 cell proliferation with an IC50 of 0.12 µM Front Oncol. 2022 Aug 5;12:933446.
panc10.05 panc10.05 MMRi62 inhibits PDAC cell proliferation Mol Cancer Ther. 2022 Apr 1;21(4):535-545.
BxPc3 BxPc3 MMRi62 inhibits PDAC cell proliferation Mol Cancer Ther. 2022 Apr 1;21(4):535-545.
Panc1 Panc1 MMRi62 inhibits PDAC cell proliferation Mol Cancer Ther. 2022 Apr 1;21(4):535-545.
MANCA cells MANCA cells MMRi62 induced MDM4 degradation in MANCA cells Front Oncol. 2022 Aug 5;12:933446.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
SCID mice Orthotopic pancreatic tumor model Intraperitoneal injection 25 mg/kg Twice per week for 31 days MMRi62 significantly inhibits tumor growth and metastasis in orthotopic pancreatic tumor models Mol Cancer Ther. 2022 Apr 1;21(4):535-545.

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.62mL

2.52mL

1.26mL

25.24mL

5.05mL

2.52mL

 

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