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Chemical Structure| 219911-35-0 Chemical Structure| 219911-35-0

Structure of MPEP HCl
CAS No.: 219911-35-0

Chemical Structure| 219911-35-0

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MPEP HCl is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.

Synonyms: MPEP (hydrochloride); MPEP Hydrochloride

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Product Details of MPEP HCl

CAS No. :219911-35-0
Formula : C14H12ClN
M.W : 229.70
SMILES Code : CC1=NC(C#CC2=CC=CC=C2)=CC=C1.[H]Cl
Synonyms :
MPEP (hydrochloride); MPEP Hydrochloride
MDL No. :MFCD02262119
InChI Key :PKDHDJBNEKXCBI-UHFFFAOYSA-N
Pubchem ID :9794588

Safety of MPEP HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of MPEP HCl

GPCR

Isoform Comparison

Biological Activity

Description
MPEP Hydrochloride is a potent, selective, noncompetitive, orally active mGlu5 receptor antagonist with an IC50 of 36 nM for inhibiting quisqualate-stimulated phosphoinositide hydrolysis. It exhibits anxiolytic and antidepressant-like effects[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.35mL

0.87mL

0.44mL

21.77mL

4.35mL

2.18mL

43.53mL

8.71mL

4.35mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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