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Chemical Structure| 1263132-08-6 Chemical Structure| 1263132-08-6

Structure of MRT-81
CAS No.: 1263132-08-6

Chemical Structure| 1263132-08-6

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MRT-81 is a smoothened (Smo) receptor antagonist that effectively inhibits the hedgehog signaling pathway, suitable for related cancer research.

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Product Details of MRT-81

CAS No. :1263132-08-6
Formula : C31H29N3O5S
M.W : 555.64
SMILES Code : O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC(NC(NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)=S)=CC=C3C
MDL No. :N/A
InChI Key :CTXQODCQOSYYDE-UHFFFAOYSA-N
Pubchem ID :56964692

Safety of MRT-81

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of MRT-81

Hedgehog

Isoform Comparison

Biological Activity

Description
MRT-81 is a strong antagonist of human and rodent smoothened (Smo) receptors, exhibiting an IC50 value of 41 nM in Shh-light2 cells and demonstrating potent hedgehog pathway inhibition. MRT-81 is utilized in cancer research[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

9.00mL

1.80mL

0.90mL

18.00mL

3.60mL

1.80mL

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