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Chemical Structure| 1460286-21-8 Chemical Structure| 1460286-21-8

Structure of MSC2504877
CAS No.: 1460286-21-8

Chemical Structure| 1460286-21-8

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MSC2504877 (M2912) is a highly potent, orally active tankyrase inhibitor with IC50 values of 0.0007 µM, 0.0008 µM, and 0.54 µM for TNKS, TNKS2, and PARP1, respectively. It increases AXIN2 and TNKS protein expression while reducing β-catenin levels, demonstrating antitumor activity.

Synonyms: M2912

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Product Details of MSC2504877

CAS No. :1460286-21-8
Formula : C17H18N2O2
M.W : 282.34
SMILES Code : O=C1C2=CC=C(C)N2C=C(C3=CC=C(C(C)(O)C)C=C3)N1
Synonyms :
M2912

Safety of MSC2504877

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of MSC2504877

epigenetics
DNA

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1 mM

5 mM

10 mM

3.54mL

0.71mL

0.35mL

17.71mL

3.54mL

1.77mL

35.42mL

7.08mL

3.54mL

 

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