Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	944252-63-5
Formula :	C₇₃H₁₁₂N₂₂O₁₆
M.W :	1553.81
SMILES Code :	O=C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCN)C(N[C@@H](CCN)C(N[C@@H](C)C(N[C@@H](CO)C(N1[C@@](CCC1)([H])C(N2[C@](CCC2)([H])C(N[C@]([C@H](O)C)([H])C3=O)=O)=O)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)CCN)=O)CCN)=O)CCCN)=O)CCN)=O)([H])[C@@H](C)CC)[C@](N3)([H])CC6=CNC7=CC=CC=C67
Synonyms :	POL7080
MDL No. :	N/A
InChI Key :	RIDRXGOBXZLKHZ-NZUANIILSA-N
Pubchem ID :	91824766

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301-H311-H331
Precautionary Statements:	P261-P280-P301+P310-P311
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

RBL-2H3 cells	10 µM	30 minutes	induces degranulation and production of TNF-α and CCL2	Front Immunol. 2021 Jun 23;12:689410
Clinical isolates	0.5 µg/mL	8 and 24 hours	Assess the bactericidal effect of Murepavadin in combination with ciprofloxacin against clinical isolates. Results showed that the combination resulted in 1.83×10^5–4.03×10^6-fold killing of all strains after 8 hours, which was 4.00×10^2–1.78×10^5-fold fewer bacteria than with each antibiotic alone.	Antibiotics (Basel). 2024 Aug 26;13(9):810
Pseudomonas aeruginosa PA14	0.05 mg/ml	8 hours	To evaluate the bactericidal effect of murepavadin in combination with colistin on P. aeruginosa PA14, results showed that the combination significantly reduced bacterial survival.	Elife. 2021 Apr 6;10:e65836
Pseudomonas aeruginosa PA14	0.05 mg/ml	10 minutes	To evaluate the effect of murepavadin on the outer membrane permeability of P. aeruginosa PA14, results showed that murepavadin increased bacterial susceptibility to colistin.	Elife. 2021 Apr 6;10:e65836
LAD2 cells	10 µM	30 minutes	induces Ca2+ mobilization, degranulation, and production of IL-8 and CCL3	Front Immunol. 2021 Jun 23;12:689410
mexZ::Tn mutant	0.5 µg/mL	8 hours and 24 hours	To evaluate the bactericidal effects of murepavadin in combination with tobramycin or amikacin against the mexZ::Tn mutant. The results showed that the combination reduced bacterial counts by 100-fold after 8 hours and by 106-fold (tobramycin) or 100-fold (amikacin) after 24 hours.	Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0153923
Wild-type Pseudomonas aeruginosa PA14	0.25 µg/mL	30 minutes	To evaluate the effect of murepavadin on bacterial survival. The results showed that treatment with 0.25 µg/mL murepavadin for 30 minutes resulted in approximately 80% bacterial survival.	Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0153923
Wild-type Pseudomonas aeruginosa PA14	0.5 µg/mL	8 hours and 24 hours	To evaluate the bactericidal effects of murepavadin in combination with tobramycin or amikacin. The results showed that the combination reduced bacterial counts by 50- to 100-fold after 8 hours and by at least 105-fold after 24 hours.	Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0153923
PAO1 and its mutants	0.015 to 32 mg/L	Overnight incubation	Determine MIC values of Murepavadin against PAO1 and its mutants	Front Cell Infect Microbiol. 2024 Dec 6;14:1446626
Pseudomonas aeruginosa clinical isolates	>0.25 mg/L		Determine MIC values of Murepavadin and study its resistance mechanisms	Front Cell Infect Microbiol. 2024 Dec 6;14:1446626
PA14	0.5 µg/mL	8 and 24 hours	Evaluate the bactericidal effect of Murepavadin in combination with ciprofloxacin. Results showed that Murepavadin and ciprofloxacin alone reduced live bacterial numbers by approximately 50 and 500 times, respectively, while the combination further reduced bacterial numbers by 1.51×10^4 and 1.50×10^3 times.	Antibiotics (Basel). 2024 Aug 26;13(9):810
Pseudomonas aeruginosa isolates	0.016 to 16 mg/liter		To determine the in vitro antimicrobial activity of Murepavadin against Pseudomonas aeruginosa isolates, with MIC50 of 0.12 mg/liter and MIC90 of 2 mg/liter	Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01541-19
Pseudomonas aeruginosa PA14	0.25 µg/mL	1 hour	To evaluate the effect of Murepavadin on bacterial membrane integrity and protein composition. Results showed that Murepavadin increased outer membrane permeability and induced the AlgU-mediated envelope stress response.	Microbiol Spectr. 2023 Sep 5;11(5):e0125723
Pseudomonas aeruginosa CF strains	0.06 to ≥128 mg/L		To evaluate the in vitro activity of murepavadin against 230 cystic fibrosis (CF) strains of Pseudomonas aeruginosa isolated from 12 French hospitals, in comparison with 12 other antipseudomonal antibiotics. Results showed that 9.1% of strains had a minimum inhibitory concentration (MIC) >4 mg/L, at least 128-fold higher than the modal MIC value of the whole collection (≤0.06 mg/L).	Antimicrob Agents Chemother. 2024 Jan 10;68(1):e0129823
P. aeruginosa DSM 25716	0.25 µg/mL	18–20 hours	MIC of 0.25 µg·mL−1 against VIM β-lactamase-expressing carbapenem-resistant strain, validating broad-spectrum activity.	Biomolecules. 2024 Apr 27;14(5):526
P. aeruginosa DSM 24600	0.03125 µg/mL	18–20 hours	Activity against ESBL-producing carbapenem-resistant strain (MIC 0.03125 µg·mL−1), demonstrating efficacy against resistant variants.	Biomolecules. 2024 Apr 27;14(5):526
P. aeruginosa ATCC 27853	0.0625 µg/mL	18–20 hours	Determination of MIC for different murepavadin batches showed consistent activity (0.0625 µg·mL−1) against P. aeruginosa ATCC 27853, confirming preserved chiral integrity.	Biomolecules. 2024 Apr 27;14(5):526

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CAS No.: 944252-63-5

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CAS No.: 944252-63-5

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Mice	Lung infection model	Intranasal administration	0.25 mg/kg murepavadin and 5 mg/kg colistin	Single dose, lasting 3 hours	To evaluate the efficacy of murepavadin in combination with colistin for treating P. aeruginosa lung infections, results showed that the combination significantly reduced bacterial load in the lungs.	Elife. 2021 Apr 6;10:e65836
Mice	MrgprB2-/- mice	Intradermal injection	30 µM	Single injection, evaluated after 30 minutes	Evaluate Murepavadin-induced vascular permeability via MrgprB2	Front Immunol. 2021 Jun 23;12:689410
Mice	Acute pneumonia model	Intranasal administration	Murepavadin: 0.25 mg/kg; Amikacin: 35 mg/kg	Single dose, 3 hours post-infection	To evaluate the therapeutic efficacy of the murepavadin-amikacin combination in a mouse acute pneumonia model. The results showed that treatment with murepavadin or amikacin alone reduced the mean bacterial load by approximately 28-fold, whereas the combined treatment reduced the mean bacterial load by 756-fold, displaying a synergistic bactericidal effect.	Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0153923
BALB/c mice	Acute pneumonia model	Intranasal administration	0.25 mg/kg Murepavadin and 0.5 mg/kg ciprofloxacin	Single dose, evaluated after 16 hours	Evaluate the in vivo bactericidal effect of Murepavadin in combination with ciprofloxacin. Results showed that Murepavadin and ciprofloxacin alone reduced bacterial loads by 33 and 43 times, respectively, while the combination reduced the mean bacterial load by 1171 times, demonstrating a synergistic bactericidal effect.	Antibiotics (Basel). 2024 Aug 26;13(9):810
CD-1 mice	Neutropenic mouse lung infection model	Subcutaneous injection	0.125 to 16 mg/kg	Every 24h, 12h, or 6h for 24h	To evaluate the pharmacodynamic properties of Murepavadin in a lung infection model and determine the correlation between pharmacodynamic indices and efficacy. Results showed that the fAUC/MIC ratio correlated best with efficacy, with mean fAUC/MIC values of 27.8 and 39.9 required for static effect and 1-log kill, respectively.	Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01699-18
BALB/c mice	Acute pneumonia model	Intranasal administration	0.25 mg/kg Murepavadin, 7.5 mg/kg Ceftazidime, 1.875 mg/kg Avibactam	Single dose, evaluated after 13 hours	To evaluate the synergistic therapeutic effect of Murepavadin in combination with Ceftazidime/Avibactam against Pseudomonas aeruginosa infection. Results showed that the combination significantly reduced bacterial loads in the lungs, demonstrating a synergistic bactericidal effect.	Microbiol Spectr. 2023 Sep 5;11(5):e0125723

NCT02110459	Renal Impairment	PHASE1	COMPLETED	2025-07-15	CRS Clinical Research Services... More >> Kiel GmbH, Kiel, 24105, Germany Less <<
NCT02096328	Ventilator Associated Pneumoni... More >>a\|Lower Respiratory Infection Less <<	PHASE2	COMPLETED	2025-12-16	ATTIKON University Hospital, A... More >>thens, Greece\|Hospital EVANGELISMOS, Athens, Greece\|Hospital KORGIALENIO-BENAKIO E.E.S, Athens, Greece\|SOTIRA Pulmonary Clinic, Athens, Greece\|Hospital Bellvitge, Barcelona, Spain\|Hospital Clinic, Barcelona, Spain\|Hospital Del Mar, Barcelona, Spain\|Hospital Clinic San Carlos, Madrid, Spain\|Hospital Joan XXIII, Tarragona, Spain\|Hospital La Fe, Valencia, Spain Less <<
NCT02096315	Bronchiectasis\|Lower Respirato... More >>ry Infection Less <<	PHASE2	TERMINATED	2025-11-15	Hospital Bellvitge, Barcelona,... More >> Spain\|Hospital Clinic, Barcelona, Spain\|Hospital La Fe, Valencia, Spain\|Royal Infirmary, City of Edinburgh, United Kingdom Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed