Mycophenolate Mofetil (RS 61443) | IMPDH Inhibitor

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CAS No. :	128794-94-5
Formula :	C₂₃H₃₁NO₇
M.W :	433.49
SMILES Code :	O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC
Synonyms :	RS 61443; TM-MMF; MMF
MDL No. :	MFCD00867568
InChI Key :	RTGDFNSFWBGLEC-SYZQJQIISA-N
Pubchem ID :	5281078

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

MRL-(Fas)lpr mice	Spontaneous autoimmune tissue injury model	Oral	100 mg/kg	Daily administration for 8 weeks	To compare the therapeutic effects of Cat-S inhibitor RO5459072 and MMF on systemic autoimmunity and lupus nephritis. RO5459072 dose-dependently reversed aberrant systemic autoimmunity (e.g., plasma cytokines, activation of myeloid cells, and hypergammaglobulinemia) and significantly suppressed IgG autoantibody production. RO5459072 also dose-dependently improved the pathological scores and proteinuria in lupus nephritis, with effects superior to MMF.	PMC5459853
C3H/HeNHsd mice	CBV3-induced myocarditis model	Oral gavage	100, 200 or 300 mg/kg/day	Twice daily for 7 consecutive days	Evaluate the protective effect of MMF on CBV3-induced myocarditis, results showed MMF significantly reduced the number of myocarditis foci	PMC317291
NZB/W F1 mice	Lupus nephritis model	Oral gavage	100 mg/kg	Once daily for 4 weeks	MMF significantly reduced serum CD44 and VCAM-1 levels to pre-nephritic levels, improving kidney inflammation and fibrosis	PMC11473352
MRL/lpr mice	Lupus nephritis model	Oral	50 mg/kg	Once daily for 8 weeks	To evaluate the efficacy of multitarget therapy (MT) in the treatment of lupus nephritis, results showed that MT therapy significantly improved systemic immune activation and renal injury.	PMC11773216
NZB/W F1 mice	Lupus nephritis model	Oral gavage	100 mg/kg	Daily administration for 24 weeks	To evaluate the therapeutic effect of mycophenolate mofetil on lupus nephritis. Results showed that mycophenolate mofetil significantly reduced proteinuria, improved survival, and attenuated tubulointerstitial inflammation and glomerular damage.	PMC5083145
C3H mice	Immunosuppressed mouse model	Oral gavage	40 mg/kg	Daily for 13 days	To study the role of mycophenolate mofetil in an immunosuppressive regimen mimicking the state of lung transplant recipients.	PMC11705917
Mice	Myocardial infarction model	Intraperitoneal injection	20 mg/kg/day	Daily until analysis	Attenuate immune response and promote cardiac reprogramming	PMC11637486

NCT05627739	Vogt-Koyanagi-Harada Disease\|M... More >>ycophenolate Mofetil Less <<		RECRUITING	2025-12-01	xiaomin Zhang, Tianjin, Tianji... More >>n, 300000, China Less <<
NCT00893958	Prophylaxis of Organ Rejection		COMPLETED	2025-01-06	CEDRA Clinical Research, Austi... More >>n, Texas, 78759, United States Less <<
NCT00893542	Prophylaxis of Organ Rejection		COMPLETED	2025-11-05	CEDRA Clinical Research, LLC, ... More >>Austin, Texas, 78759, United States Less <<
NCT05951517	Henoch-Sch?nlein Purpura\|Gastr... More >>ointestinal Injury\|Mycophenolate Mofetil Less <<		RECRUITING	2026-12-31	Sun Yat-sen Memorial Hospital,... More >> Sun Yat-sen University, Guangzhou, Guangdong, 510120, China Less <<
NCT00367146	Liver Transplantation\|Chronic ... More >>Kidney Disease Less <<		COMPLETED	2025-08-08	Hannover medical School, Hanno... More >>ver, 30625, Germany Less <<
NCT05129410	Idiopathic Inflammatory Myopat... More >>hy\|Interstitial Lung Disease Less <<	PHASE4	UNKNOWN	2023-11-30	Department of Rheumatology,the... More >> First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China Less <<
NCT00894088	Prophylaxis of Organ Rejection		COMPLETED	2025-01-06	CEDRA Clinical Research, Austi... More >>n, Texas, 78759, United States Less <<
NCT04868786	Hematopoietic Stem Cell Transp... More >>lantation Less <<	PHASE1	RECRUITING	2025-10-25	Seoul National University Hosp... More >>ital, Seoul, 03080, Korea, Republic of Less <<
NCT00001764	Vasculitis\|Wegener's Granuloma... More >>tosis Less <<	PHASE1	COMPLETED	2025-06-04	National Institute of Allergy ... More >>and Infectious Diseases (NIAID), Bethesda, Maryland, 20892, United States Less <<
NCT05101447	Lupus Nephritis	PHASE2	WITHDRAWN	2025-07-24	-
NCT01283867	FED	PHASE1	COMPLETED	2025-12-07	Lambda Therapeutic Research Lt... More >>d, Bodakdev, Ahmedabad, 3 80 054, India Less <<
NCT00166153	Cardiac Transplantation		TERMINATED	2025-05-05	Children's Healthcare of Atlan... More >>ta, Atlanta, Georgia, 30322, United States Less <<
NCT00531635	Post Transplant in Immunosuppr... More >>ession w/CSA & Mycophenolate Mofetil Less <<	PHASE1	UNKNOWN	2025-06-12	KFSH&RC, Riyadh, 11211, Saudi ... More >>Arabia Less <<
NCT03920059	Lupus Nephritis	PHASE4	TERMINATED	2020-01-30	King Chulalongkorn Memorial Ho... More >>spital, Bangkok, Please Select, 10330, Thailand Less <<
NCT00166244	De Novo Renal Transplant Recip... More >>ient. Less <<	PHASE4	COMPLETED	2025-04-06	John Hunter Hospital, New Lamb... More >>ton, New South Wales, 2305, Australia\|Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia\|Monash Medical Centre, Clayton, Victoria, 3168, Australia\|St Vincent's Hospital, Melbourne, Victoria, 3065, Australia\|Royal Melbourne Hospital, Parkville, Victoria, 3052, Australia\|Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009, Australia\|Royal Perth Hospital, Perth, Western Australia, 6847, Australia\|Med. Univ. Klinik, Graz, 8036, Austria\|AKH Wien, Vienna, Vienna, Austria\|University Hospitals Leuven, Leuven, 3000, Belgium\|Hospital do Rim e Hipertensao, Sao Paulo, CEP 0438-002, Brazil\|Vancouver General Hospital, Vancouver, British Columbia, V5Z 1M9, Canada\|Ruijin Hospital, Shanghai, Shanghai, 200001, China\|West China Hospital of Sichuan University, Chengdu, Sichuan, China\|Odense University Hospital, Odense, 5000, Denmark\|Surgical Clinic Of Tartu University Clinics, Tartu, 51014, Estonia\|Hopital Pellegrin, C.H.R.de Bordeaux, Bordeaux, 33076, France\|Hospital du Bocage, Dijon, 21000, France\|CHU de Grenoble, Grenoble, 38043, France\|CHU Kremlin Bicêtre, Kremlin Bicêtre, 94275, France\|Hopital Calmette, Lille, 59037, France\|Hopital Jeanne de Flandres, Lille, 59037, France\|Centre Hospitalier Regional Universitaire, Limoges, 87042, France\|CHU Hotel Dieu, Nantes, 44093, France\|Hopital Necker, Paris, 75015, France\|Hopital Tenon, Paris, 75020, France\|Centre Hospitalier Lyon Sud, Pierre Benite, 69495, France\|Hopital Foch, Suresnes, 92151, France\|CHU Purpan, Toulouse, 31059, France\|CHU Rangueil, Toulouse, 31059, France\|CHU de Nancy-Brabois, Vandoeuvre-les-Nancy, 54511, France\|Universitatsklinikum Charite, Berlin, 10098, Germany\|Chirurgische Universit?tsklinik, Freiburg, 79106, Germany\|Universitatsklinikum Heidelberg, Heidelberg, 69120, Germany\|University of Heidelberg, Heidelberg, 69120, Germany\|Stadt Kliniken Koln, Koln, 51009, Germany\|University Hospital Wurzburg, Wurzburg, 97080, Germany\|Vilnius University Hospital, Vilnius, 2021, Lithuania\|Leids Universitair Medisch Centrum, Leiden, 2333, Netherlands\|Erasmus Medical Center Rotterdam, Rotterdam, 3000, Netherlands\|Rikshopitalet, Oslo, 0027, Norway\|Institute of Transplantology, Medical University of Warsaw, Warsaw, 02-006, Poland\|Children's Memorial Health Institute, Warsaw, 04-736, Poland\|Hospital Son Dureta, Palma De Mallorca, 07014, Spain\|Hospital Infanta Christa, Badajoz, 06080, Spain\|Hospital Del Mar, Barcelona, 08003, Spain\|Valle de Hebron, Barcelona, 08035, Spain\|Hospital Sant Joan de Deu, Barcelona, 8950, Spain\|Hospital Reina Sofia, Cordoba, 14004, Spain\|Hospital de las Nieves, Granada, 18014, Spain\|Hospital Ramon Y Cajal, Madrid, 28034, Spain\|Fundacion Jimenez Diaz, Madrid, 28040, Spain\|Hospital Clinico San Carlos, Madrid, 28040, Spain\|La Paz, Madrid, 28046, Spain\|Complejo Hospitalario Univeritario de Santiago, Santiago De Compostela, 15706, Spain\|Hospital Virgen del Rocio, Sevilla, 41013, Spain\|Hospital Dr. Peset, Valencia, Spain\|University Hospital, Malmo, Malmo, 205 02, Sweden\|Karolinska University Hospital, Huddinge, Stockholm, 141 86, Sweden\|University Hospital A, Uppsala, 751 85, Sweden\|National Taiwan University Hospital, Taipei, Taiwan\|Royal Free Hospital, London, NW3 2QG, United Kingdom\|Guys and St Thomas's Hospital, London, SE1 9RT, United Kingdom\|St George's Hospital, London, SW17 ORE, United Kingdom\|Hospital "Miguel Perez Carreno", Caracas, Venezuela\|Hospital Universitario de Caracas, Caracas, Venezuela\|Hospital Universitario de Maracaibo, Maracaibo, Venezuela Less <<
NCT00187941	Transplantation, Renal\|Immunos... More >>uppression Less <<	EARLY_PHASE1	COMPLETED	2025-11-06	University of Florida, Gainesv... More >>ille, Florida, 32610, United States Less <<
NCT00217152	Kidney Transplantation\|Delayed... More >> Graft Function Less <<	PHASE4	TERMINATED	2025-08-07	Mayo Clinic, Rochester, Minnes... More >>ota, 55905, United States Less <<
NCT03517982	Acute Transplant Rejection in ... More >>Patients Receiving Allogeneic Renal Transplant Less <<		COMPLETED	2025-09-16	Prince Hamza Hospital, Amman, ... More >>Jordan Less <<
NCT00199667	Kidney Transplant Recipients	PHASE4	UNKNOWN	-	Néphrologie, Amiens, 80000, Fr... More >>ance\|Néphrologie, Angers, 49000, France\|Néphrologie, Caen, 14000, France\|Néphrologie, Limoges, 87042, France\|Néphrologie, Paris, 75000, France\|Néphrologie, Poitiers, 86000, France\|Néphrologie, Reims, 51000, France\|Néphrologie, Rouen, 76000, France\|Néphrologie, Strasbourg, 67000, France\|Néphrologie, Toulouse, 31059, France\|Néphrologie, Tours, 37000, France Less <<
NCT01283841	Fasting	PHASE1	COMPLETED	2025-12-07	Lambda Therapeutic Research Lt... More >>d, Bodakdev, Ahmedabad, 3 80 054, India Less <<
NCT00433186	Diffuse Cutaneous Systemic Scl... More >>erosis Less <<	PHASE1	COMPLETED	2025-03-11	Boston University School of Me... More >>dicine, Boston, Massachusetts, 02118, United States Less <<
NCT00004567	Vasculitis\|Wegener's Granuloma... More >>tosis Less <<	PHASE2	COMPLETED	2025-06-04	National Institute of Allergy ... More >>and Infectious Diseases (NIAID), Bethesda, Maryland, 20892, United States Less <<

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CAS No.: 128794-94-5

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CAS No.: 128794-94-5

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Product Details of Mycophenolate Mofetil

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Biological Activity

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Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.31mL 0.46mL 0.23mL	11.53mL 2.31mL 1.15mL	23.07mL 4.61mL 2.31mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed