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Chemical Structure| 537-55-3 Chemical Structure| 537-55-3
Chemical Structure| 537-55-3

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N-Acetyl-L-tyrosine is an acetylated derivative of L-tyrosine and exhibits inhibition of acetylserotonin O-methyltransferase.

Synonyms: NAT; NSC 10853; Acetyl tyrosine

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Product Details of Ac-Tyr-OH

CAS No. :537-55-3
Formula : C11H13NO4
M.W : 223.23
SMILES Code : OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(C)=O
Synonyms :
NAT; NSC 10853; Acetyl tyrosine
MDL No. :MFCD00037190
InChI Key :CAHKINHBCWCHCF-JTQLQIEISA-N
Pubchem ID :68310

Safety of Ac-Tyr-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Ac-Tyr-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 537-55-3 ]

[ 537-55-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 537-55-3 ]
  • [ 88847-89-6 ]
  • [ 1042442-14-7 ]
  • 2
  • [ 1206723-73-0 ]
  • [ 22744-12-3 ]
  • [ 537-55-3 ]
  • 3
  • [ 253168-94-4 ]
  • [ 537-55-3 ]
  • (S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine)-N-acetyl-L-tyrosine salt [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% In methanol; at 60℃; for 2h; Into a 250mL three-necked flask, add 50mL of methanol and 2g of (R,S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(formamido)-2-ethylamine respectively, 0.8g N-acetyl-L-tyrosine, the feed ratio of (R,S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(formamido)-2-ethylamine and N-acetyl-L-tyrosine is 1:0.6 (molar ratio), stir and heat to reflux at 60C, continue refluxing for 2 hours. Stop heating, cool at room temperature, cool at 25C, incubate and stir for 3 hours, suction filter, filter cake rinsed with methanol and dry, and obtained Apremilast intermediate: N-Acetyl-L-tyrosine salt crude of (S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(formamido)-2-ethylamine 1.65g, yield 69%.
 

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