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Chemical Structure| 31750-48-8 Chemical Structure| 31750-48-8

Structure of N-Desmethyltamoxifen
CAS No.: 31750-48-8

Chemical Structure| 31750-48-8

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N-Desmethyltamoxifen is the main metabolite of Tamoxifen and a stronger protein kinase C (PKC) inhibitor. It has application potential in ceramide metabolism regulation and cancer research.

4.5 *For Research Use Only !

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Product Details of N-Desmethyltamoxifen

CAS No. :31750-48-8
Formula : C25H27NO
M.W : 357.49
SMILES Code : CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OCCNC
MDL No. :N/A
InChI Key :NYDCDZSEEAUOHN-IZHYLOQSSA-N
Pubchem ID :6378383

Safety of N-Desmethyltamoxifen

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H350-H360-H372
Precautionary Statements:P264-P270-P301+P312+P330-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of N-Desmethyltamoxifen

epigenetics

Isoform Comparison

Biological Activity

Description
N-Desmethyltamoxifen, the primary human metabolite of tamoxifen, exhibits weaker antiestrogen properties but is ten times more effective as a protein kinase C (PKC) inhibitor than tamoxifen itself. Additionally, it acts as a strong regulator of ceramide metabolism in human AML cells, restricting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation [1][2][3].

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Bio Calculators
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2.80mL

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27.97mL

5.59mL

2.80mL

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