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Chemical Structure| 183241-73-8 Chemical Structure| 183241-73-8

Structure of N-Lactoyl-Phenylalanine
CAS No.: 183241-73-8

Chemical Structure| 183241-73-8

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N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite used in obesity research, which can be induced by exercise.

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Product Details of N-Lactoyl-Phenylalanine

CAS No. :183241-73-8
Formula : C12H15NO4
M.W : 237.25
SMILES Code : O=C(O)[C@H](CC1=CC=CC=C1)NC([C@@H](O)C)=O
MDL No. :MFCD34676338

Safety of N-Lactoyl-Phenylalanine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice (C57BL/6J) Diet-induced obesity (DIO) model Oral 100, 300 or 600 mg/kg Single dose, observed for 24 hours To investigate the effect of metformin on plasma Lac-Phe levels in mice. Results showed metformin significantly increased plasma Lac-Phe levels. Nat Metab. 2024 Apr;6(4):659-669
Mice Diet-induced obese mice Intraperitoneal injection 50 mg/kg Once daily for 10 days To study the effect of Lac-Phe on obesity and glucose homeostasis, results showed that Lac-Phe significantly reduced food intake, body weight, and adiposity, and improved glucose homeostasis. Nature. 2022 Jun;606(7915):785-790
Mice SLC17A1-KO and SLC17A3-KO mice Intraperitoneal injection 50 mg/kg Single dose, urine collected 30 minutes post-injection To validate the in vivo transport role of SLC17A1 and SLC17A3 for Lac-Phe. Results showed a ~30% and 40% reduction in urine Lac-Phe levels in SLC17A1-KO and SLC17A3-KO mice, respectively, with no changes in plasma Lac-Phe levels or body weight. Nat Commun. 2024 Aug 12;15(1):6895

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.21mL

0.84mL

0.42mL

21.07mL

4.21mL

2.11mL

42.15mL

8.43mL

4.21mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
 

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