Narazaciclib (ON123300) | CDK4/ARK5 Inhibitor

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CAS No. :	1357470-29-1
Formula :	C₂₄H₂₇N₇O
M.W :	429.52
SMILES Code :	N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O
Synonyms :	ON 123300; ON123300
MDL No. :	MFCD28411414
InChI Key :	VADOZMZXXRBXNY-UHFFFAOYSA-N
Pubchem ID :	56649281

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Ba/F3-FLT3-ITD cells	95.32 nM		Tested the inhibitory effect of Narazaciclib on the proliferation of Ba/F3-FLT3-ITD cells, showing potent inhibition.	PMC11031590
M2-Macrophages	72.5 nM		Tested the inhibitory effect of Narazaciclib on the proliferation of M2-Macrophages, showing potent inhibition.	PMC11031590
Ba/F3-RBM6-CSF1R cells	36.94 nM		Tested the inhibitory effect of Narazaciclib on the proliferation of Ba/F3-RBM6-CSF1R cells, showing potent inhibition.	PMC11031590
Ba/F3-CSF1R cells	3.54 nM		Tested the inhibitory effect of Narazaciclib on the proliferation of Ba/F3-CSF1R cells, showing potent inhibition.	PMC11031590
Ba/F3-CSF1R cells	3.54 nM(IC50)		To test the inhibitory effect of ON123300 on CSF1R-driven cell proliferation	PMC11031590
GBM39 cells	4 μM		Evaluate the effect of ON123300 on phosphorylation of Akt and Erk in GBM39 cells, showing 55% inhibition of Akt phosphorylation and 174% activation of Erk phosphorylation	PMC4013241
U87 cells	6.3 μM	1 h	Evaluate the inhibitory effect of ON123300 on phosphorylation of Akt and its downstream signaling molecules, showing decreased phosphorylation levels of Akt, P70S6K, rpS6, and Rb S780, while increased phosphorylation of Erk	PMC4013241
U87 glioma cells	3.4 ± 0.1 μM(IC50)	72 h	Evaluate the inhibitory effect of ON123300 on U87 glioma cell proliferation, showing an IC50 of 3.4 ± 0.1 μM	PMC4013241
MEM2 (ibrutinib-resistant MCL)	500nM–5µM	24 h	ON123300 induced apoptosis in both ibrutinib-sensitive and resistant MCL cells	PMC4703501
MEM1 (ibrutinib-sensitive MCL)	500nM–5µM	24 h	ON123300 induced apoptosis in both ibrutinib-sensitive and resistant MCL cells	PMC4703501
Z138C	0.1–1.0µM(IC50)	24 h	ON123300 induced G1 phase cell cycle arrest at lower concentrations and apoptosis at higher concentrations	PMC4703501
Granta 519	0.1–1.0µM(IC50)	24 h	ON123300 induced G1 phase cell cycle arrest at lower concentrations and apoptosis at higher concentrations	PMC4703501
multiple myeloma cell lines EJM	50 nM	48 h	To evaluate the antiproliferative effect of ON123300 on multiple myeloma cell lines, results showed that ON123300 significantly reduced cell viability at 50 nM concentration	PMC5968814
multiple myeloma cell lines MM1.S	50 nM	48 h	To evaluate the antiproliferative effect of ON123300 on multiple myeloma cell lines, results showed that ON123300 significantly reduced cell viability at 50 nM concentration	PMC5968814
multiple myeloma cell lines NCI-H929	50 nM	48 h	To evaluate the antiproliferative effect of ON123300 on multiple myeloma cell lines, results showed that ON123300 significantly reduced cell viability at 50 nM concentration	PMC5968814
multiple myeloma cell lines MM.1R	50 nM	48 h	To evaluate the antiproliferative effect of ON123300 on multiple myeloma cell lines, results showed that ON123300 significantly reduced cell viability at 50 nM concentration	PMC5968814
Ba/F3-FLT3-ITD cells	95.32 nM(IC50)		To test the inhibitory effect of ON123300 on FLT3-ITD-driven cell proliferation	PMC11031590
M2 primary macrophages	72.5 nM(IC50)	7 days	To test the inhibitory effect of ON123300 on M2 macrophage proliferation	PMC11031590
Ba/F3-RBM6-CSF1R cells	36.94 nM(IC50)		To test the inhibitory effect of ON123300 on RBM6-CSF1R fusion protein-driven cell proliferation	PMC11031590

Mice	MV4-11 subcutaneous tumor model	Intraperitoneal injection	100 mg/kg	Twice per week for 3 weeks	Tested the inhibitory effect of Narazaciclib on MV4-11 subcutaneous tumor growth, showing significant inhibition.	PMC11031590
NIH Swiss nude mice	U87 glioma model	Intravenous injection	5 mg/kg and 25 mg/kg	Single dose	Evaluate the pharmacokinetic and pharmacodynamic properties of ON123300 in the U87 glioma model, showing high distribution of ON123300 in brain and brain tumor with a brain partition coefficient of at least 2.5. Single agent ON123300 caused dose-dependent suppression of Akt phosphorylation and activation of Erk, while addition of GFN significantly enhanced p-Akt inhibition and prevented Erk activation	PMC4013241
CD-1 mice	Z138C cell xenograft model	Intraperitoneal injection	100mg/kg	Daily or every alternate day for 14 days	ON123300 significantly inhibited MCL tumor growth without obvious toxicity	PMC4703501
NSG mice	Multiple myeloma xenograft model	Intraperitoneal injection	100 mg/kg	Administered every alternate day until tumor diameter exceeded 1 cm or body weight loss exceeded 10%	To evaluate the in vivo antitumor effect of ON123300 on multiple myeloma, results showed that ON123300 significantly inhibited tumor growth	PMC5968814
NOD/scid mice	MV4-11 subcutaneous tumor model	Intraperitoneal injection	100 mg/kg	Twice per week for 3 weeks	To test the inhibitory effect of ON123300 on FLT3-ITD-driven AML tumor growth	PMC11031590

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CAS No.: 1357470-29-1

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CAS No.: 1357470-29-1

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed