Structure of Nateglinide
CAS No.: 105816-04-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
Synonyms: A4166; Senaglinide; Starlix
4.5
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| CAS No. : | 105816-04-4 |
| Formula : | C19H27NO3 |
| M.W : | 317.42 |
| SMILES Code : | O=C(O)[C@@H](CC1=CC=CC=C1)NC([C@H]2CC[C@H](C(C)C)CC2)=O |
| Synonyms : |
A4166; Senaglinide; Starlix
|
| MDL No. : | MFCD00875706 |
| InChI Key : | OELFLUMRDSZNSF-OFLPRAFFSA-N |
| Pubchem ID : | 5311309 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H302-H361 |
| Precautionary Statements: | P201-P202-P264-P270-P281-P301+P312-P308+P313-P330-P405-P501 |
| Target |
|
In Vitro:
|
Cell Line
|
Concentration | Treated Time | Description | References |
| BRIN-BD11 cells | 100 μM | 18 h | 18-hour exposure to 100 mM nateglinide abolished the acute insulinotropic effects of nateglinide, tolbutamide, and glibenclamide, but did not affect the insulinotropic effect of efaroxan. | Br J Pharmacol. 2004 May;142(2):367-73. |
| BRIN-BD11 cells | 10–400 μM | 20 min | Nateglinide induced a concentration-dependent increase in insulin release at non-stimulatory glucose concentrations and evoked K ATPchannel-independent insulin secretion in depolarized cells. | Br J Pharmacol. 2004 May;142(2):367-73. |
In Vivo:
|
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
| Mice | Streptozotocin (STZ)-induced diabetic mice | Oral | 150 mg/kg | Every 3 days for 130 days | To evaluate the effectiveness of Ins@Alg/NG in regulating blood glucose levels in diabetic mice, results showed that Ins@Alg/NG significantly reduced blood glucose levels and restored pancreatic function. | Adv Sci (Weinh). 2023 Oct;10(29):e2301879 |
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT03492580 | - | Completed | - | United States, New Jersey ... More >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 Less << | |
| NCT02456428 | - | Completed | - | Canada, Quebec ... More >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Less << | |
| NCT02475499 | - | Completed | - | Canada, Quebec ... More >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Less << | |
| NCT02476760 | - | Completed | - | Canada, Quebec ... More >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Less << | |
| NCT02616666 | Type 2 Diabetes Mellitus | Phase 4 | Recruiting | December 31, 2021 | - |
| NCT01456130 | Diabetes Mellitus | Phase 3 | Completed | - | Japan ... More >> Nagoya-shi, Aichi, Japan Fukuoka-shi, Fukuoka, Japan Kurume-shi, Fukuoka, Japan Sapporo-shi, Hokkaido, Japan Kobe-shi, Hyogo, Japan Kagoshima-shi, Kagoshima, Japan Kumamoto-shi, Kumamoto, Japan Osaki-shi, Miyagi, Japan Minou-shi, Osaka, Japan Osaka-shi, Osaka, Japan Kamio-shi, Saitama, Japan Koshigaya-shi, Saitama, Japan Adachi-ku, Tokyo, Japan Chuo-ku, Tokyo, Japan Less << |
| NCT01697592 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | - |
| NCT01919489 | Type 2 Diabetes | Phase 4 | Recruiting | June 2019 | United States, Florida ... More >> University of Miami Recruiting Miami, Florida, United States Contact: Gianluca Iacobellis, MD GIacobellis@med.miami.edu Principal Investigator: Gianluca Iacobellis, MD United States, Georgia Grady Memorial Hospital Recruiting Atlanta, Georgia, United States, 30303 Contact: Guillermo E Umpierrez, MD 404-778-1665 geumpie@emory.edu Contact: Francisco J Pasquel, MD 404 778 1697 fpasque@emory.edu Principal Investigator: Guillermo Umpierrez, MD Sub-Investigator: Francisco J Pasquel, MD Sub-Investigator: Priya Vellanki, MD Emory University Hospital Recruiting Atlanta, Georgia, United States, 30324 Contact: Francisco Pasquel, MD fpasque@emory.edu Sub-Investigator: Francisco Pasquel, MD Emory Universtiy Hospital at MIdtown Recruiting Atlanta, Georgia, United States Contact: Francisco Pasquel, MD Sub-Investigator: Rodolfo J Galindo, MD United States, New York State University of NY at Buffalo Recruiting New York, New York, United States Contact: Ajay Chaudhuri, MD AChaudhuri@KaleidaHealth.Org Principal Investigator: Ajay Chaudhuri, MD Less << |
| NCT02143765 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | China, Jiangsu ... More >> The First People's Hospital of Changzhou Changzhou, Jiangsu, China The Second People's Hospital of Huai'an Huai'an, Jiangsu, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Southeast University Nanjing, Jiangsu, China Xuzhou Central Hospital Xuzhou, Jiangsu, China Yancheng City No.1 People's Hospital Yancheng, Jiangsu, China Zhenjiang First People's Hospital Zhenjiang, Jiangsu, China Less << |
| NCT01697592 | - | Completed | - | - | |
| NCT00212290 | Insulin Resistance ... More >> Type 2 Diabetes Mellitus Less << | Phase 4 | Completed | - | United States, Washington ... More >> VA Puget Sound Health Care System (Seattle Campus) Seattle, Washington, United States, 98108 VA Puget Sound Health Care System (American Lake Campus) Tacoma, Washington, United States, 98493 Less << |
| NCT00259168 | Insulin Resistance|Impaired Fa... More >>sting Glucose Less << | PHASE4 | COMPLETED | 2025-03-06 | Endothelial laboratory, Cardio... More >>logy clinic Y-research, H:S Bispebjerg Hospital, Bispebjerg Bakke, Copenhagen, Copenhagen NV, 2400, Denmark Less << |
| NCT00461617 | Diabetes | Phase 3 | Completed | - | - |
| NCT00369148 | Type 2 Diabets Mellitus | Phase 4 | Completed | - | Japan ... More >> Nippon Kokan Hospital Kawasaki, Kanagawa, Japan, 210-0852 Hamamatsu Red Cross Hospital Hamamatsu, Shizuoka, Japan, 430-0907 Saiseikai Central Hospital Minato-ku, Tokyo, Japan, 108-0073 Kitasato Institute Hospital Minato-ku, Tokyo, Japan, 108-8642 Keio University Hospital Shinjuku-ku, Tokyo, Japan, 160-8582 Tokyo Metropolitan Ohtsuka Hospital Toshima-ku, Tokyo, Japan, 170-8476 Less << |
| NCT01456130 | - | Completed | - | - | |
| NCT00189774 | Type 2 Diabetes Mellitus ... More >> Diabetes Mellitus, Type II Less << | Phase 2 Phase 3 | Completed | - | Japan ... More >> Chubu region, Japan Chugoku region, Japan Hokkaido region, Japan Kanto region, Japan Kinki region, Japan Kyushu region, Japan Tohoku region, Japan Less << |
| NCT00437918 | Diabetes Mellitus ... More >> Type 2 Diabetes Mellitus Less << | Phase 4 | Completed | - | Korea, Republic of ... More >> Paik Diabetes Center, Pusan Paik Hospital, College of Medicine, Inje University Busan, Korea, Republic of, 614-735 Endocrinology and Metabolism, Maryknoll General Hospital Busan, Korea, Republic of Less << |
| NCT03283358 | Intermittent Claudication | Not Applicable | Recruiting | December 31, 2020 | Sweden ... More >> Department of Surgery, Unit of Vascular Surgery, Södersjukhuset Recruiting Stockholm, Sweden, SE-11883 Contact: Sara Haile, RN +46 8 6162462 sara.haile@sodersjukhuset.se Principal Investigator: Anneli Linné, MD, PhD Karolinska University Hospital, Dept of Vascular Surgery Recruiting Stockholm, Sweden Contact: Ulrika Palmer Kazen, MD, PhD 08-51770000 Principal Investigator: Ulrika Palmer Kazen, MD, PhD Less << |
| NCT00097786 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00238472 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT00319189 | Renal Transplant Recipients|Po... More >>sttransplant Diabetes Mellitus|Posttransplant Impaired Glucose Tolerance Less << | PHASE4 | COMPLETED | 2025-11-03 | Rikshospitalet, Section of Nep... More >>hrology, Oslo, 0027, Norway Less << |
| NCT01030952 | - | Completed | - | - | |
| NCT00402909 | Type 2 Diabetes | PHASE4 | COMPLETED | 2025-08-07 | Novartis Pharmaceuticals, East... More >> Hanover, New Jersey, 07974, United States Less << |
| NCT00928889 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | China ... More >> People's Liberation Army. The Military General Hospital of BeiJing BeiJing, China, 100020 Peiking University First Hospital BeiJing, China, 100034 Chinese PLA General Hospital Beijing, China, 100853 The First Affiliated Hospital, Zhongshan (Sun Yat-sen) University Guangzhou, China, 510080 The Second Affiliated Hospital, Zhongshan (Sun Yat-sen) University Guangzhou, China, 510120 Nanfang Hospital, the Affiliated South Hospital of the Southern Medical University Guangzhou, China, 510515 Less << |
| NCT00097786 | - | Completed | - | - | |
| NCT02088918 | Healthy Volunteers | Phase 1 | Completed | - | Korea, Republic of ... More >> Chungnam University Hospital Daejeon, Korea, Republic of Less << |
| NCT00928889 | - | Completed | - | - | |
| NCT00858013 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Korea, Republic of ... More >> Myongji Hospital Ilsan, Kyounggi, Korea, Republic of Hanyang University Medical Center Guri-si, Kyunggi-do, Korea, Republic of Inha University Hospital Incheon, Korea, Republic of Hallym University Medical Center Seoul, Korea, Republic of Korea University Guro Hospital Seoul, Korea, Republic of Kyung hee University Medical Center Seoul, Korea, Republic of Ajou University Hospital Suwon-si, Korea, Republic of Less << |
| NCT01030952 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | China ... More >> Sir Run Run Shaw Hospital, 3 East Qingchun Road Hangzhou, China, 310016 Shanghai Tongji Hospital, 389 Xinchun Road Shanghai, China, 200065 Shanghai Sixth People's Hospital, 600 Xuanshan Road Shanghai, China, 200233 Less << |
| NCT01159158 | Healthy | PHASE1 | COMPLETED | 2025-02-07 | - |
| NCT01160029 | Healthy | PHASE1 | COMPLETED | 2025-10-04 | - |
| NCT01316107 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Japan ... More >> Hokkaido, Japan Kantou, Japan Kyushu, Japan Touhoku, Japan Less << |
| NCT00858013 | - | Completed | - | - |
[4]Halas CJ. Nateglinide. Am J Health Syst Pharm. 2001;58(13):1200-1205
[5]Dunn CJ, Faulds D. Nateglinide. Drugs. 2000;60(3):607-617
Tags: Nateglinide | A4166 | Senaglinide | A 4166 | A-4166 | Potassium Channel | Dipeptidyl Peptidase | KcsA | DPP | glucose | insulin | diabetes | 105816-04-4
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