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Chemical Structure| 1508250-71-2 Chemical Structure| 1508250-71-2

Structure of Nazartinib
CAS No.: 1508250-71-2

Chemical Structure| 1508250-71-2

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EGF816 inhibits mutant EGFR (L858R/790M) with Ki of 31 nM irreversibly and selectively.

Synonyms: EGF816; NVS-816

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Product Details of Nazartinib

CAS No. :1508250-71-2
Formula : C26H31ClN6O2
M.W : 495.02
SMILES Code : O=C(C1=CC(C)=NC=C1)NC2=NC3=CC=CC(Cl)=C3N2[C@H]4CN(C(/C=C/CN(C)C)=O)CCCC4
Synonyms :
EGF816; NVS-816
MDL No. :MFCD28963918
InChI Key :IOMMMLWIABWRKL-WUTDNEBXSA-N
Pubchem ID :72703790

Safety of Nazartinib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Nazartinib

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • EGFR/ErbB1

    mutant EGFR, Ki:0.031 μM

  • mutant EGFR

    mutant EGFR, Ki:0.031 μM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02108964 Advanced Non-small Cell Lung C... More >>ancer Less << PHASE1|PHASE2 COMPLETED 2023-08-15 Massachusetts General Hospital... More >> Mass General, Boston, Massachusetts, 02114, United States|Memorial Sloan Kettering Oncology Department, New York, New York, 10017, United States|Novartis Investigative Site, Toronto, Ontario, M5G 2M9, Canada|Novartis Investigative Site, Berlin, 13125, Germany|Novartis Investigative Site, Koeln, 50937, Germany|Novartis Investigative Site, Nagoya, Aichi, 464 8681, Japan|Novartis Investigative Site, Fukuoka-city, Fukuoka, 811-1395, Japan|Novartis Investigative Site, Seoul, 03080, Korea, Republic of|Novartis Investigative Site, Seoul, 05505, Korea, Republic of|Novartis Investigative Site, Zoetermeer, NL-2722 EP, Netherlands|Novartis Investigative Site, Singapore, 168583, Singapore|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Madrid, 28041, Spain|Novartis Investigative Site, Taipei, 10002, Taiwan Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.10mL

2.02mL

1.01mL

20.20mL

4.04mL

2.02mL

References

 

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