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Chemical Structure| 337349-54-9 Chemical Structure| 337349-54-9

Structure of Necrostatin-5
CAS No.: 337349-54-9

Chemical Structure| 337349-54-9

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Necrostatin-5 is a potent necroptosis and RIP1 kinase inhibitor with an EC50 of 0.24 µM. This molecule has significant cardioprotective effects and is widely used in research on the regulation of necrotic cell death.

Synonyms: Nec-5

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Product Details of Necrostatin-5

CAS No. :337349-54-9
Formula : C19H17N3O2S2
M.W : 383.49
SMILES Code : N#CCSC1=NC2=C(C3=C(CCCC3)S2)C(N1C4=CC=C(OC)C=C4)=O
Synonyms :
Nec-5
InChI Key :VGONMECBFMCKBS-UHFFFAOYSA-N
Pubchem ID :1913406

Safety of Necrostatin-5

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319-H413
Precautionary Statements:P264-P273-P280-P305+P351+P338-P337+P313-P501

Related Pathways of Necrostatin-5

pyroptosis

Isoform Comparison

Biological Activity

Description
Necrostatin-5 (Nec-5) effectively inhibits necroptosis with an EC50 of 0.24 µM and acts as a RIP1 inhibitor, demonstrating cardioprotective properties[1][2][3].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.08mL

5.22mL

2.61mL

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