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Chemical Structure| 906-33-2 Chemical Structure| 906-33-2

Structure of Neochlorogenic acid
CAS No.: 906-33-2

Chemical Structure| 906-33-2

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Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein.

Synonyms: trans-5-O-Caffeoylquinic acid; 5-Caffeoylquinic Acid; 5-O-Caffeoylquinic acid

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Product Details of Neochlorogenic acid

CAS No. :906-33-2
Formula : C16H18O9
M.W : 354.31
SMILES Code : O=C([C@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@@H](O)[C@H](O)C1)O
Synonyms :
trans-5-O-Caffeoylquinic acid; 5-Caffeoylquinic Acid; 5-O-Caffeoylquinic acid
MDL No. :MFCD10566639
InChI Key :CWVRJTMFETXNAD-NXLLHMKUSA-N
Pubchem ID :5280633

Safety of Neochlorogenic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of Neochlorogenic acid

pyroptosis

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Rat bone marrow mesenchymal stem cells (BMSCs) 0, 0.4, 0.8, 1.6, 3.2, 6.4 µM 24 hours Evaluated the cytotoxicity of Ncg on BMSCs, found that 1.6 μM concentration had the strongest proliferative effect. Biomacromolecules. 2024 Feb 12;25(2):729-740
HepG2 cells 40-120 µM 24 hours 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway Int J Mol Sci. 2021 Dec 6;22(23):13163
Rat aortic vascular smooth muscle cells (A7r5 cell line) 40, 80, 120 µM 24 hours Inhibited OH-induced proliferation and migration of A7r5 cells by suppressing FAK/Src, PI3K/Akt, and Ras-related signaling pathways Nutrients. 2022 Jul 22;14(15):3006
A549 cells 0, 25, 50, 100 µM 24 hours To investigate the anti-inflammatory effects of nCGA on LPS-stimulated inflammatory response in A549 cells. Results showed that nCGA significantly reduced the production of TNF-α, IL-6, and NO, and suppressed the protein expression of iNOS, COX2, TNF-α, and IL-6. Additionally, nCGA inhibited NF-κB activation and blocked MAPKs signaling pathway phosphorylation. Molecules. 2020 Mar 18;25(6):1385
Rat bone marrow mesenchymal stem cells (BMSCs) 1.6 µM 7 days Evaluated the effect of Ncg on chondrogenic differentiation of BMSCs, found that Ncg promoted BMSCs differentiation toward cartilage and secretion of more Aggrecan. Biomacromolecules. 2024 Feb 12;25(2):729-740

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Db/db mice High-fat diet-induced diabetic fatty liver model Gavage 250 mg/kg Once daily for 12 weeks To investigate the protective effects of neochlorogenic acid on high-fat diet-induced diabetic fatty liver. Results showed that neochlorogenic acid significantly improved serum lipid profiles, liver fat deposition conditions, steatohepatitis levels, and liver antioxidant activity. J Agric Food Chem. 2024 Mar 27;72(12):6339-6346

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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