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Chemical Structure| 51857-17-1 Chemical Structure| 51857-17-1
Chemical Structure| 51857-17-1

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NH2-C6-NH-Boc is a PROTAC linker belonging to the alkyl/ether class, used for Mcl-1 inhibitors based on PROTAC technology.

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Product Details of N-Boc-1,6-Diaminohexane

CAS No. :51857-17-1
Formula : C11H24N2O2
M.W : 216.32
SMILES Code : NCCCCCCNC(OC(C)(C)C)=O
MDL No. :MFCD00671489
InChI Key :RVZPDKXEHIRFPM-UHFFFAOYSA-N
Pubchem ID :2733170

Safety of N-Boc-1,6-Diaminohexane

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of N-Boc-1,6-Diaminohexane

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51857-17-1 ]

[ 51857-17-1 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 51857-17-1 ]
  • [ 72040-63-2 ]
  • (6-{6-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoylamino]-hexanoylamino}-hexyl)-carbamic acid tert-butyl ester [ No CAS ]
  • 2
  • [ 51857-17-1 ]
  • [ 7310-97-6 ]
  • [ 1448695-79-1 ]
  • 3
  • [ 51857-17-1 ]
  • [ 169624-67-3 ]
  • C37H45N3O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.9 g Synthesis of Fmoc-Phe-Gly-NH-(CH2)6NH-Boc To a solution of <strong>[169624-67-3]Fmoc-Phe-Gly-OH</strong> (0.66 g) in anhydrous THF (20 mL) at 0 C. under N2 was added N,N'-dicyclohexylcarbodiimide (0.307 g) and 1-hydroxybenzotriazole hydrate (0.201 g). After stirring for 15 min, N-Boc-1,6-diaminohexane (0.322 g) was added. The reaction mixture was allowed to warm to RT and stirred overnight. Solids were filtered off and they were washed with EtOAc. The filtrate and washings were then concentrated under reduced pressure. The resulting residue was purified by flash column chromatography (0 to 10% MeOH in CH2Cl2) to afford Fmoc-Phe-Gly-NH-(CH2)6NH-Boc as a white solid (0.9 g).
  • 4
  • [ 55750-49-7 ]
  • [ 51857-17-1 ]
  • [ 124529-64-2 ]
 

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