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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1884640-99-6 Chemical Structure| 1884640-99-6

Structure of NI-42
CAS No.: 1884640-99-6

Chemical Structure| 1884640-99-6

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NI 42 is a selective inhibitor of BRPF with Kd values of 40, 210 and 943 nM for BRPF1B, 2 and 3, respectively. It also exhibits modest activity at BRD9 (Kd = 1130 nM).

Synonyms: compound 13-d

4.5 *For Research Use Only !

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Product Details of NI-42

CAS No. :1884640-99-6
Formula : C18H15N3O3S
M.W : 353.40
SMILES Code : CN1C(C(C)=CC2=CC(NS(C3=CC=C(C#N)C=C3)(=O)=O)=CC=C21)=O
Synonyms :
compound 13-d
MDL No. :MFCD30290161
InChI Key :BMVCSXFOQPYKKC-UHFFFAOYSA-N
Pubchem ID :118933132

Safety of NI-42

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of NI-42

epigenetics

Isoform Comparison

Biological Activity

Target
  • BRPF

    BRPF1, IC50:48 nM

    BRPF3, IC50:260 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.15mL

2.83mL

1.41mL

28.30mL

5.66mL

2.83mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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