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Chemical Structure| 1233332-14-3 Chemical Structure| 1233332-14-3

Structure of NIBR0213
CAS No.: 1233332-14-3

Chemical Structure| 1233332-14-3

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NIBR-0213 is a highly effective and orally active selective S1P1 receptor antagonist, showing significant efficacy in experimental autoimmune encephalomyelitis (EAE). In GTPγ35S assays, NIBR-0213 exhibits IC50 values of 2.0 nM and 2.3 nM for human and rat S1P1, respectively, demonstrating strong antagonistic effects on the S1P1 receptor, and is applicable in autoimmune disease research.

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Product Details of NIBR0213

CAS No. :1233332-14-3
Formula : C27H29ClN2O3
M.W : 464.98
SMILES Code : C[C@H](NC(C1=C(C)C=C(C2=CC=CC(N[C@@H](C3=CC=C(Cl)C(C)=C3)C)=C2)C=C1C)=O)C(O)=O
MDL No. :MFCD25977008

Safety of NIBR0213

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of NIBR0213

GPCR

Isoform Comparison

Biological Activity

Description
NIBR-0213 emerges as a potent, orally active antagonist of the S1P1 receptor, demonstrating efficacy in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. NIBR-0213 exhibits remarkable potency and selectivity towards S1P1 across species, with IC50 values of 2.0 nM and 2.3 nM in human and rat S1P1 receptors, respectively, in GTPγ35S assays[1].

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