Structure of Nimodipine
CAS No.: 66085-59-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.
Synonyms: BAY-e 9736
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CAS No. : | 66085-59-4 |
Formula : | C21H26N2O7 |
M.W : | 418.44 |
SMILES Code : | O=C(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCOC |
Synonyms : |
BAY-e 9736
|
MDL No. : | MFCD00153848 |
InChI Key : | UIAGMCDKSXEBJQ-UHFFFAOYSA-N |
Pubchem ID : | 4497 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H373 |
Precautionary Statements: | P264-P270-P301+P312+P330-P501-P260 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
GBM#P3 cells | 50 μmol/ml | 48 hours | Nimodipine inhibited CANX expression and reduced TMZ-induced LC3B-II accumulation | Theranostics. 2025 Jan 27;15(6):2624-2648. |
LN229 cells | 50 μmol/ml | 48 hours | Nimodipine inhibited CANX expression and reduced TMZ-induced LC3B-II accumulation | Theranostics. 2025 Jan 27;15(6):2624-2648. |
T98G cells | 50 μmol/ml | 48 hours | Nimodipine inhibited CANX expression and reduced TMZ-induced LC3B-II accumulation | Theranostics. 2025 Jan 27;15(6):2624-2648. |
Primary microglia | 10 μM | 24 hours | Nimodipine induced microglia-specific apoptosis | Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3295-E3304. |
BV-2 cells | 10 μM | 24 hours | Nimodipine induced microglia-specific apoptosis and decreased NO and iNOS levels | Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3295-E3304. |
N9 cells | 10 μM | 24 hours | Nimodipine induced microglia-specific apoptosis and decreased NO and iNOS levels | Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3295-E3304. |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Nude mice | GBM intracranial xenograft model | Oral | 2 mg/kg | Once daily for 28 days | Nimodipine enhanced the chemotherapeutic effect of TMZ, significantly inhibiting tumor growth and prolonging survival | Theranostics. 2025 Jan 27;15(6):2624-2648. |
Mice | Experimental autoimmune encephalomyelitis (EAE) model | Subcutaneous injection | 10 mg/kg | Every other day for 10 days | Nimodipine treatment alleviated EAE severity, reduced the numbers of reactive astrocytes, activated microglial, and infiltrating immune cells in the spinal cord, and decreased demyelinated lesions. These changes were correlated with improved clinical scores and motor performance. | J Neuroinflammation. 2023 Nov 14;20(1):263 |
SJL/J mice | Experimental autoimmune encephalomyelitis (EAE) | Subcutaneous injection | 10 mg/kg BW | Daily for 19-37 days | Nimodipine attenuated clinical EAE, promoted remyelination, and reduced microglia numbers and inflammatory responses | Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3295-E3304. |
Mice | Cerebellar nuclear neurons | Bath application | 10 μM | Nimodipine replaces the hyperpolarizing step by blocking L-type calcium channels, facilitating LTP induction | Neuron. 2010 May 27;66(4):550-9 | |
Mice | Self-biting behavior model | Subcutaneous injection | 20 mg/kg | Single dose | Pretreatment with nimodipine significantly reduced self-biting behavior induced by ( 6)Bay K 8644 | Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15228-32 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03434314 | Aortic Aneurysm, Thoracoabdomi... More >>nal Less << | Not Applicable | Not yet recruiting | September 2021 | Austria ... More >> Medizinische Universität Innsbruck Not yet recruiting Innsbruck, Austria Contact: Michael Grimm, Prof. Dr. +43 512 504 22500 michael.grimm@tirol-kliniken.at Contact: Johannes Holfeld, Dr. johannes.holfeld@i-med.ac.at Herzzentrum Hietzing Not yet recruiting Vienna, Austria Contact: Martin Grabenwöger, Prof. Dr. +43 1 4020585 Martin.Grabenwoeger@wienkav.at Contact: Gabriel Weiss, Dr. gabriel.weiss@wienkav.at France University Hospital of Bordeaux Not yet recruiting Bordeaux, France Contact: Eric Ducasse, Prof. Dr. +335 56 79 55 25 eric.ducasse@chu-bordeaux.fr Marie Lannelongue Hospital Not yet recruiting Le Plessis-Robinson, France Contact: Stephan Haulon, Prof. Dr. Germany Uniklinik RWTH Aachen Not yet recruiting Aachen, Germany Contact: Michael Jacobs, Prof. Dr. +49 241 8085197 mjacobs@ukaachen.de Contact: Drosos Kotelis, Dr. dkotelis@ukaachen.de Deutsches Herzzentrum Berlin Not yet recruiting Berlin, Germany Contact: Volkmar Falk, Prof. Dr. falk@dhzb.de Contact: Semih Buz, Dr. buz@dhzb.de Universitätsklinikum Düsseldorf Not yet recruiting Düsseldorf, Germany Contact: Hubert Schelzig, Prof. Dr. 0049 211 81 07211 hubert.schelzig@med.uni-duesseldorf.de Contact: Alexander Oberhuber, Dr. Alexander.Oberhuber@med.uni-duesseldorf.de Westdeutsches Herz und Gefäßzentrum Essen Not yet recruiting Essen, Germany Contact: Heinz Jakob, Prof. Dr. +49 201 723 4901 heinz.jakob@uk-essen.de Contact: Konstantinos Tsagakis, Dr. Konstantinos.Tsagakis@uk-essen.de Universitäts-Herzzentrum Freiburg/ Bad Krozingen Not yet recruiting Freiburg, Germany Contact: Martin Czerny, Prof. Dr. +49 7633 402 6216 martin.czerny@universitaets-herzzentrum.de Herzzentrum Hamburg Not yet recruiting Hamburg, Germany Contact: Tilo Kölbel, Prof. Dr. +49 40 7410 58609 t.koelbel@uke.de Medizinische Hochschule Hannover Not yet recruiting Hanover, Germany Contact: Axel Haverich, Prof. Dr. 0049 511- 532 6580 haverich.axel@mh-hannover.de Contact: Malakh Shrestha, Prof. Dr. 0049 511- 532 6238 Shrestha.Malakh.lal@mh-hannover.de Universitätsklinikum Heidelberg Not yet recruiting Heidelberg, Germany Contact: Dittmar Böckler, Prof. Dr. 0049 6221 56 6249 dittmar.boeckler@med.uni-heidelberg.de Contact: Moritz Bischoff, Dr. moritz.bischoff@med.uni-heidelberg.de Herzzentrum Leipzig Not yet recruiting Leipzig, Germany Contact: Christian D Etz, Prof. Dr. +49 341 865 251007 christian.etz@medizin.uni-leipzig.de UniversitätskIinikum Leipzig Not yet recruiting Leipzig, Germany Contact: Scheinert Dierk, Prof.Dr. +49 341 97 18770 dierk.scheinert@medizin.uni-leipzig.de Klinikum rechts der Isar (TU München) Not yet recruiting Munich, Germany Contact: Hans-Henning Eckstein, Prof. Dr. +49 89 4140 9244 H.H.Eckstein@lrz.tum.de Contact: Sarah Geisbüsch, Dr. sarah.geisbuesch@mri.tum.de Klinikum der Universität München (LMU) Not yet recruiting München, Germany Contact: Maximilian Luehr, Dr. + 49 89 4400 72436 maximilian.luehr@med.uni-muenchen.de St. Franziskus-Hospital GmbH Not yet recruiting Münster, Germany Contact: Giovanni Torsello, Prof. Dr. 0049 251 935-3933 giovanni.torsello@ukmuenster.de Contact: Theodosios Bisdas, Dr. theodosios.bisdas@sfh-muenster.de Paracelsus Universität - Klinikum Nürnberg Not yet recruiting Nuremberg, Germany Contact: Eric Verhoeven, Prof. Dr. 0049 911 398 117004 eric.verhoeven@klinikum-nuernberg.de Contact: Athanasios Katsargyris, Dr. Athanasios.Katsargyris@klinikum-nuernberg.de Universitätsklinikum Regensburg Not yet recruiting Regensburg, Germany Contact: Karin Pfister, Prof. Dr. +49 941 944 6911 Karin.Pfister@klinik.uni-regensburg.de Contact: Piotr Kasprzak, Prof. Dr. piotr.kasprzak@ukr.de Universitätsklinikum Tübingen Not yet recruiting Tübingen, Germany Contact: Christian Schlensak, Prof. Dr. 0049 7071 29 86638 christian.schlensak@med.uni-tuebingen.de Contact: Mario Lescan, Dr. mario.lescan@med.uni-tuebingen.de Italy S.Orsola-Malpighi Hospital Not yet recruiting Bologna, Italy Contact: Davide Pacini, Prof. Dr. +39 051 6363329 davide.pacini@unibo.it Ospedale San Raffaele SRL Not yet recruiting Milano, Italy Contact: Roberto Chiesa, Prof. Dr. +39 02 2643 7148 chiesa.roberto@unisr.it Contact: Germano Melissano, Prof. Dr. +39 02 2643 7148 melissano.germano@hsr.it Netherlands Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands Contact: Michael Jacobs, Prof. Dr. m.jacobs@mumc.nl Contact: Barend Mees, Dr. +31 43 3877478 barend.mees@mumc.nl Poland Medical University of Warsaw Not yet recruiting Warsaw, Poland Contact: Tomasz Jakimowicz, Dr. tomj@wum.edu.pl Silesian Center for Heart Diseases Not yet recruiting Zabrze, Poland Contact: Marian Zembala, Prof. Dr. +48 323733689 m.zembala@sccs.pl; sek.kch@sccs.pl Contact: Maciej K Kolowca, Dr. maciej@kolowca.eu Sweden Lund University Hospital Malmoe Not yet recruiting Malmö, Sweden Contact: Tim Resch, Dr. tim.resch@med.lu.se Örebro University Hospital Not yet recruiting Örebro, Sweden Contact: Thomas Larzon, Prof. Dr. thomas.larzon@regionorebrolan.se Switzerland Bern University Hospital Not yet recruiting Bern, Switzerland Contact: Jürg Schmidli, Prof. Dr. +41 31 632 26 02 juerg.schmidli@insel.ch United Kingdom St Bartholomews Hospital Not yet recruiting London, United Kingdom Contact: Aung Y Oo, Prof. Dr. AungYe.OO@Bartshealth.nhs.uk Less << |
NCT03718780 | Pulmonary Disease, Chronic Obs... More >>tructive Lung Diseases, Interstitial Chronic Heart Failure Pulmonary Arterial Hypertension Hyperventilation Syndrome Healthy Less << | Not Applicable | Not yet recruiting | March 2020 | France ... More >> Service de pneumologie Not yet recruiting Béthune, France, 62408 Contact: Frédéric BART Principal Investigator: Frédéric BART Service de pneumologie CHMS Not yet recruiting Chambéry, France, 73000 Contact: Serge Kouzan Sub-Investigator: Julien PERNOT Sub-Investigator: Marie COUDURIER Principal Investigator: Serge KOUZAN Service de réanimation médicale - CHMS Not yet recruiting Chambéry, France, 73000 Contact: Jean-Marc THOURET Jean-Marc.Thouret@ch-metropole-savoie.fr Contact: Vincent PEIGNE vincent.peigne@ch-metropole-savoie.fr Sub-Investigator: Jean-Marc THOURET Principal Investigator: Vincent PEIGNE Service de Pneumologie CHU Grenoble Not yet recruiting La Tronche, France, 38700 Contact: Bernard AGUILANIU Principal Investigator: Bernard AGUILANIU Less << |
NCT00001478 | - | Completed | - | United States, Maryland ... More >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Less << | |
NCT01715662 | Lower Limb Amputation | Not Applicable | Completed | - | Canada, British Columbia ... More >> Holy Family Hospital Vancouver, British Columbia, Canada, V5P 3L6 GF Strong Vancouver, British Columbia, Canada, V5Z 2G9 St. Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 Less << |
NCT02774031 | Male Urogenital Diseases ... More >> Female Urogenital Diseases Less << | Not Applicable | Completed | - | Norway ... More >> Department of Anesthesia, St.Olavs University Hospital Trondheim, Norway, 7006 Less << |
NCT03022162 | - | Not yet recruiting | August 31, 2017 | - | |
NCT02545777 | Acute Gouty Arthritis | Phase 2 | Unknown | - | China, Beijing ... More >> No.3 Hospital Affiliated to Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100029 Contact: Lou Xi Nen, Doctor 13601181885 13601181885@163.com Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100700 Contact: Zhao Jiu Li, Doctor 84013229 dzmk@163.net Less << |
NCT01138683 | Acute Decompensated Heart Fail... More >>ure Less << | Phase 3 | Completed | - | Belgium ... More >> University Hospital Ghent Ghent, Belgium Less << |
NCT03457324 | Irritable Bowel Syndrome | Phase 2 Phase 3 | Recruiting | June 30, 2020 | China, Hong Kong ... More >> Chinese Medicine Clinics of Hong Kong Baptist University Recruiting Hong Kong, Hong Kong, China Contact: Zhao-xiang Bian, PhD 852-34112905 bzxiang@hkbu.edu.hk China Institute of Digestive Disease, The Chinese University of Hong Kong Not yet recruiting Hong Kong, China Contact: Justin Wu, M.D 2632 3524 justinwu@cuhk.edu.hk Less << |
NCT01206283 | Brain Injuries ... More >> Subarachnoid Hemorrhage Less << | Not Applicable | Completed | - | Bosnia and Herzegovina ... More >> Department of Neurosurgery, Clinical Centre University of Sarajevo Sarajevo, Bosnia and Herzegovina, 71000 Less << |
NCT02515838 | Sickle-Cell Disease | Phase 2 | Recruiting | March 2019 | Bahrain ... More >> Salmaniya Hospital, Kingdom of Bahrain Recruiting Manama, Bahrain Contact: Dr Najat Mahdi, MD Salmaniya Medical Complex, Bahrain Recruiting Manama, Bahrain Contact: Dr. Mohamed Hassan Nafea, MD Jamaica Annotto Bay Hospital Completed Annotto Bay, Jamaica Kingston Public Hospital Completed Kingston, Jamaica University Hospital of the West Indies Completed Kingston, Jamaica Winchester Surgical and Medical Institute Completed Kingston, Jamaica Mandeville Regional Hospital Completed Mandeville, Jamaica May Pen Public Hospital Clarendon Completed May Pen, Jamaica Cornwall Regional Hospital, Jamaica Completed Montego Bay, Jamaica Lebanon American University of Beirut Medical Center, Beirut, Cairo street, Beirut, Lebanon Recruiting Beirut, Lebanon Contact: Dr Miguel Abboud, MD Nini Hospital Recruiting Tripoli, Lebanon Contact: Dr. Adlette Inati, MD Netherlands Dept of Haematology Recruiting Amsterdam, Netherlands Contact: Dr. Bart J Biemond, MD PhD Erasmus MC Completed Rotterdam, Netherlands Oman Sultan Qaboos University Hospital Alkhodh, Oman Recruiting Muscat, Oman Contact: Prof. Yasser Wali, MD Sultan Qaboos University Recruiting Muscat, Oman Contact: Dr. Murtadha Al-Khabori , MD Saudi Arabia King Fahd Medical City, As Sulimaniyah, Riyadh Saudiarabien Recruiting Riyadh, Saudi Arabia Contact: Alaa Morsi, MD King Saud University, Riyadh, Saudiarabien Recruiting Riyadh, Saudi Arabia Contact: Rahman Al Sultan, MD Turkey Mersin University Faculty of Medicine Recruiting Adana, Mersin, Turkey Contact: Dr. Anıl Tombak, MD Cukurova University Faculty Of Medicine Tıp Fakültesi Recruiting Adana, Turkey Contact: Prof. Yurdanur Kilinc, MD Dr Antmen Recruiting Adana, Turkey Contact: Dr Antmen, MD Less << |
NCT01829581 | - | Completed | - | - | |
NCT01959009 | Respiratory Distress Syndrome,... More >> Newborn Bronchopulmonary Dysplasia Ventilator Induced Lung Injury Less << | Not Applicable | Active, not recruiting | June 2018 | Denmark ... More >> Department of Neonatology, Rigshospitalet Copenhagen, Denmark, 2100 Less << |
NCT01825057 | See One Do On... More >>e Order One Less << | Phase 4 | Unknown | June 2017 | United States, Connecticut ... More >> Yale School of Medicine New Haven, Connecticut, United States, 06511 Less << |
NCT01582360 | - | Unknown | January 2018 | Norway ... More >> Oslo University Hospital Recruiting Oslo, Norway Principal Investigator: Elin Helset, MD PhD Principal Investigator: Jan Fr Bugge, MD PhD Principal Investigator: Hilde Ma Sporsem, cand pharm Principal Investigator: Yvonne Lao, cand pharm Principal Investigator: Kirsti Andersson, MD Less << | |
NCT00288665 | Acute Myocardial Infarction ... More >> Ventricular Remodeling Less << | Phase 4 | Completed | - | Netherlands ... More >> St Antonius Hospital Nieuwegein, Netherlands, 3435CM Less << |
NCT01955785 | Traumatic Brain Injury | Not Applicable | Completed | - | Norway ... More >> Dept Intensive Care Medicine, St Olavs University Hospital Trondheim, Norway, 7006 Less << |
NCT03433690 | High Intensity Interval Traini... More >>ng Child Obesity Less << | Not Applicable | Completed | - | - |
NCT02569385 | - | Unknown | August 2016 | Germany ... More >> University Hospital RWTH Aachen, Department of Medical Clinic I Recruiting Aachen, 52074, Germany Principal Investigator: Michael Dreher, MD Sub-Investigator: Johannes Bickenbach, MD Less << | |
NCT00910195 | Obstructive Sleep Apnea | Not Applicable | Completed | - | Germany ... More >> Wissenschaftliches Institut Bethanien e.V. Solingen, NRW, Germany, 42699 Less << |
NCT03216044 | - | Completed | - | - | |
NCT01442168 | Malaria, Falciparum | Phase 1 Phase 2 | Terminated | - | Thailand ... More >> Mae Ramat Hospital Mae Ramat, Tak province, Thailand Maesot General hospital Mae Sot, Tak Province, Thailand Hospital for Tropical Diseases Bangkok, Thailand Less << |
NCT02907879 | - | Recruiting | February 2020 | Switzerland ... More >> Department of Neurosurgery, University Hospital Bern Recruiting Bern, Switzerland, 3010 Contact: Jürgen Beck, MD 031 632 2409 juergen.beck@insel.ch Contact: Werner Z`Graggen, MD 031 632 2409 werner.zgraggen@insel.ch Principal Investigator: Jürgen Beck, MD Sub-Investigator: Werner Z`Graggen, MD Less << | |
NCT03411746 | - | Recruiting | July 31, 2019 | Italy ... More >> Rosanna Vaschetto Recruiting Novara, Italy, 28100 Contact: Rosanna Vaschetto, Professor +393342724811 rosanna.vaschetto@med.uniupo.it Less << | |
NCT00317213 | Smoking | Phase 2 | Completed | - | Israel ... More >> Arazi Clinic and Modus Clinic Tel-Aviv and Rehovot, Israel Less << |
NCT00000280 | Cocaine-Related Disorders | PHASE1 | COMPLETED | 1999-08-01 | VA Connecticut Healthcare Syst... More >>em, New Haven, Connecticut, 06519, United States Less << |
NCT02983396 | Chest Pain ST... More >> Elevation Myocardial Infarction Less << | Not Applicable | Unknown | October 2017 | Belgium ... More >> Algemeen Ziekenhuis Sint-Jan Brugge Recruiting Brugge, Belgium, 8000 Contact: Yves Vandekeckhove, MD University Hospital Ghent Recruiting Ghent, Belgium, 9000 Contact: Yves taeymans, MD, Phd AZ Sint Nikolaas Recruiting St. Niklaas, Belgium, 9100 Contact: Joeri Voet, MD Less << |
NCT03150524 | Reversible Cerebral Vasoconstr... More >>iction Syndrome Less << | Phase 4 | Recruiting | May 31, 2019 | United States, Maryland ... More >> Johns Hopkins Bayview Medical Center Recruiting Baltimore, Maryland, United States, 21210 Contact: Elisabeth B Marsh, MD 410-550-8703 ebmarsh@jhmi.edu Contact: Rafael H Llinas, MD 410-550-1042 rllinas@jhmi.edu Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21287 Contact: Elisabeth B Marsh, MD 410-550-8703 ebmarsh@jhmi.edu Contact: Rafael H Llinas, MD 410-550-1042 rllinas@jhmi.edu Less << |
NCT00814658 | Dementia | Phase 4 | Completed | - | - |
NCT01962818 | Respiratory Distress Syndrome ... More >>In Premature Infants Bronchopulmonary Dysplasia Ventilator-Induced Lung Injury Functional Residual Capacity Less << | Not Applicable | Active, not recruiting | July 2019 | Australia, Queensland ... More >> Department of Neonatology, Mater Mothers Hospital Brisbane, Queensland, Australia, 4101 Less << |
NCT00814658 | - | Completed | - | - | |
NCT02165644 | Acute Cerebrovascular Accident... More >> Vasospasm Less << | Phase 2 | Withdrawn(The PI is leaving th... More >>e University of Florida.) Less << | - | - |
NCT03028090 | - | Completed | - | United States, Colorado ... More >> Memorial Health System Colorado Springs, Colorado, United States, 80909 United States, Ohio Bethesda North Hospital Montgomery, Ohio, United States, 45242 Less << | |
NCT00004399 | Pre-eclampsia | Not Applicable | Completed | - | - |
NCT03288766 | - | Recruiting | January 2019 | United States, North Carolina ... More >> Vidant Medical Center Recruiting Greenville, North Carolina, United States, 27834 Contact: Connie Rogers, ADN CRogers@vidanthealth.com Less << | |
NCT02991157 | Subarachnoid Hemorrhage, Aneur... More >>ysmal Less << | COMPLETED | 2025-12-18 | NIMHANS, Bengaluru, India | |
NCT00000332 | Cocaine-Related Disorders | PHASE2 | COMPLETED | 2000-04-01 | Washington DC VA, Washington, ... More >>District of Columbia, 20422, United States Less << |
NCT00781326 | Depression | Phase 4 | Terminated(Final cost of study... More >> medication was significantly greater than initial estimate,) Less << | - | United States, Pennsylvania ... More >> University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT03228498 | Vascular Cognitive Impairment | Phase 2 | Recruiting | September 1, 2019 | Italy ... More >> Stroke Unit, VAS-COG clinic, Azienda Ospedaliero Universitaria Careggi Recruiting Firenze, Italy, 50134 Contact: Leonardo Pantoni, MD, PhD +39-055-2751897 leonardo.pantoni@unifi.it Sub-Investigator: Anna Poggesi, MD, PhD Less << |
NCT00000738 | AIDS Dementia Complex ... More >> HIV Infections Less << | Phase 1 | Completed | - | United States, California ... More >> UCLA CARE Center CRS Los Angeles, California, United States, 90095 United States, Illinois Northwestern University CRS Chicago, Illinois, United States, 60611 United States, Indiana Indiana Univ. School of Medicine, Infectious Disease Research Clinic Indianapolis, Indiana, United States, 46202 United States, Massachusetts Massachusetts General Hospital ACTG CRS Boston, Massachusetts, United States, 02114 Bmc Actg Crs Boston, Massachusetts, United States, 02118 Beth Israel Deaconess - East Campus A0102 CRS Boston, Massachusetts, United States, 02215 United States, Minnesota University of Minnesota, ACTU Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington U CRS St. Louis, Missouri, United States United States, New York Univ. of Rochester ACTG CRS Rochester, New York, United States, 14642 United States, North Carolina Unc Aids Crs Chapel Hill, North Carolina, United States, 27599 United States, Ohio Case CRS Cleveland, Ohio, United States, 44106 United States, Washington University of Washington AIDS CRS Seattle, Washington, United States Less << |
NCT02248233 | Cerebral Infarction | Phase 4 | Completed | - | - |
NCT02893826 | Subarachnoid Hemorrhage, Aneur... More >>ysmal Less << | Phase 1 | Terminated(Based on DMC recomm... More >>endation to discontinue EG-01-1962-03) Less << | - | United States, Arizona ... More >> Dignity Health; St. Joseph's Hospital and Medical Center Phoenix, Arizona, United States, 85013 United States, California University of California San Francisco San Francisco, California, United States, 94143 United States, Maryland University of Maryland Medical Systems Baltimore, Maryland, United States, 21201 Canada, Alberta University of Alberta Hospital/Mackenzie Health Sciences Centre Edmonton, Alberta, Canada, T6G 2B7 Less << |
NCT00781326 | - | Terminated(Final cost of study... More >> medication was significantly greater than initial estimate,) Less << | - | - | |
NCT01220622 | Stroke Mild C... More >>ognitive Impairment Less << | Phase 4 | Unknown | July 2012 | China ... More >> Beijing Tian Tan Hospital, Capital Medical University Recruiting Beijing, China Contact: Feng tao, M.D. 00861067098343 happyft@sina.com Contact: Wang xuemei, M.D. minnie_wxm@hotmail.com Less << |
NCT01893190 | Ruptured Cerebral Aneurysm ... More >> Ruptured Berry Aneurysm Less << | Phase 1 Phase 2 | Completed | - | - |
NCT01672801 | Unexplained Infertility ... More >> Polycystic Ovarian Syndrome Anovulatory Less << | Not Applicable | Completed | - | United States, Massachusetts ... More >> Boston IVF Waltham, Massachusetts, United States, 02451 Less << |
NCT02537080 | Mild Cognitive Impairment | Not Applicable | Terminated(higher POCD in nimo... More >>dipine Group) Less << | December 2017 | Czech Republic ... More >> University Hospital Hradec Kralove, Czech Republic, 50005 Less << |
NCT02790632 | Subarachnoid Hemorrhage, Aneur... More >>ysmal Less << | Phase 3 | Terminated(DMC review conclude... More >>d study has a low probability of meeting its primary endpoint) Less << | - | - |
NCT01551368 | Infertility | Phase 2 | Terminated(small number of pat... More >>ients got recruited) Less << | July 2017 | Canada, Ontario ... More >> Toronto Centre for Advanced reproductive Technology (TCART) Toronto, Ontario, Canada, M5S2X9 Less << |
NCT03671525 | Schizophrenia ... More >> Schizo Affective Disorder Less << | Early Phase 1 | Recruiting | October 2019 | United States, Maryland ... More >> Johns Hopkins Bayview Medical Center Recruiting Baltimore, Maryland, United States, 21224 Contact: Frederick Nucifora, M.D Johns Hopkins University Not yet recruiting Baltimore, Maryland, United States, 21287 Less << |
NCT01835665 | Progranulin Mutation Carriers | PHASE1 | COMPLETED | 2025-05-16 | UCSF Memory and Aging Center, ... More >>San Francisco, California, 94158, United States Less << |
NCT04649398 | Subarachnoid Hemorrhage, Aneur... More >>ysmal|Delayed Cerebral Ischemia|Vasospasm, Cerebral Less << | RECRUITING | 2025-12-31 | Medical University of Vienna, ... More >>Vienna, 1090, Austria Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.39mL 0.48mL 0.24mL |
11.95mL 2.39mL 1.19mL |
23.90mL 4.78mL 2.39mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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