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Chemical Structure| 799264-47-4 Chemical Structure| 799264-47-4

Structure of Nodinitib-1
CAS No.: 799264-47-4

Chemical Structure| 799264-47-4

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ML130 is a selective and potent NOD1 inhibitor with IC50 of 560 nM. It inhibits NOD1-induced NF-κB activation.

Synonyms: ML130; CID-1088438

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Product Details of Nodinitib-1

CAS No. :799264-47-4
Formula : C14H13N3O2S
M.W : 287.34
SMILES Code : NC1=NC2=CC=CC=C2N1S(=O)(C3=CC=C(C)C=C3)=O
Synonyms :
ML130; CID-1088438
MDL No. :MFCD04322367
InChI Key :SRFABRWQVPCPRG-UHFFFAOYSA-N
Pubchem ID :1088438

Safety of Nodinitib-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HEK293 cells 5 µM 72 hours Inhibition of NOD1 activity enhanced HCMV replication Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7818-E7827

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice Collagenase-induced ICH model Lateral ventricle injection 20 μM Single administration 30 min prior to ICH induction To assess the effect of NOD1/RIP2 signaling inhibition on ICH-induced brain injury, results showed that ML130 or GSK583 treatment significantly reduced injury volume, brain edema, and neurological deficits. J Neuroinflammation. 2020 Dec 1;17(1):364.
C57BL6 mice Colon cancer liver metastasis model Intraperitoneal injection 50 mM/kg Single dose, observed for 21 days To evaluate the effect of NOD1 activation on liver metastasis of MC38 colon cancer cells. Results showed that compared to the DMSO control group, the C12-iE-DAP stimulated group had a significantly higher number of liver surface metastatic nodules (37 ± 7 vs. 3 ± 1), while the ML130 co-incubation group significantly reduced the number of metastatic nodules (14 ± 8). Protein Cell. 2020 Mar;11(3):187-201

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.48mL

0.70mL

0.35mL

17.40mL

3.48mL

1.74mL

34.80mL

6.96mL

3.48mL

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