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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1610022-76-8 Chemical Structure| 1610022-76-8

Structure of Nrf2-IN-1
CAS No.: 1610022-76-8

Chemical Structure| 1610022-76-8

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Nrf2-IN-1 is an Nrf2 inhibitor primarily used in studies on acute myeloid leukemia (AML), exerting potential anticancer effects by modulating oxidative stress pathways.

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of Nrf2-IN-1

CAS No. :1610022-76-8
Formula : C21H22ClN3O2
M.W : 383.87
SMILES Code : O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN1CC3=CC=C(C(C)(C)C)C=C3)NO
MDL No. :MFCD30747872

Safety of Nrf2-IN-1

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H228-H315-H319
Precautionary Statements:P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:4.1
UN#:1325
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Beas-2B cells 10 µM 2 hours Nrf2-IN-1 significantly reversed the effect of RES on the increase in Beas-2B cell viability and reduction of LDH and Fe2+ contents under heat stress. BMC Pharmacol Toxicol. 2024 Nov 19;25(1):88

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.03mL

2.61mL

1.30mL

26.05mL

5.21mL

2.61mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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