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Chemical Structure| 54490-26-5 Chemical Structure| 54490-26-5

Structure of NSC745887
CAS No.: 54490-26-5

Chemical Structure| 54490-26-5

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NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.

Synonyms: NSC745887

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Product Details of NSC745887

CAS No. :54490-26-5
Formula : C16H8N2O2
M.W : 260.25
SMILES Code : O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4
Synonyms :
NSC745887
MDL No. :N/A

Safety of NSC745887

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of NSC745887

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3.84mL

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19.21mL

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38.42mL

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3.84mL

 

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