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Chemical Structure| 1092499-93-8 Chemical Structure| 1092499-93-8

Structure of NVP-BSK805
CAS No.: 1092499-93-8

Chemical Structure| 1092499-93-8

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NVP-BSK805 is a selective JAK2 and JAK2(V617F) mutant inhibitor with IC50 value of 0.48 nM, with >20-fold selectivity over TYK2, JAK3 and JAK1 (IC50 values of 10.8, 18.7 and 31.6 nM, respectively).

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Product Details of NVP-BSK805

CAS No. :1092499-93-8
Formula : C27H28F2N6O
M.W : 490.55
SMILES Code : FC1=C(C(F)=CC(C2=C3N=C(C4=CN(C5CCNCC5)N=C4)C=NC3=CC=C2)=C1)CN6CCOCC6
MDL No. :MFCD22419018
InChI Key :IBPVXAOOVUAOKJ-UHFFFAOYSA-N
Pubchem ID :46398810

Safety of NVP-BSK805

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of NVP-BSK805

epigenetics
RTK
JAK-STAT

Isoform Comparison

Biological Activity

Description
NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC50 values of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively[1].

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