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CAS No. :	7500-53-0
Formula :	C₁₀H₁₀O₄
M.W :	194.18
SMILES Code :	O=C(O)CC1=CC=CC=C1CC(O)=O
Synonyms :	1,2-Benzenediacetic acid
MDL No. :	MFCD00004329
InChI Key :	MMEDJBFVJUFIDD-UHFFFAOYSA-N
Pubchem ID :	24123

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
56%	With hydrogenchloride; water;Reflux;	Example No.3. Synthesis of 2,2'-(l,2-phenylene)diacetic acid.[0055] The above dinitrile was dissolved in 50 mL concentrated HC1 and refluxed for 3 h. Water (30 mL) was added and the reaction heated overnight, then cooled and washed with ether. The organic layer was extracted twice with sodium carbonate. Combined aqueous layers were acidified and extracted with ether, which was dried (MgSO4), filtered and concentrated. The diacid was obtained as a pale yellow solid in 56% yield: mp 123 - 125 C; 1H NMR (250 MHz, DMSO-D6) 5 3.58 (s, 4H), 7.20 (s, 4H), 12.34 (br s, 2H); 13C NMR (63 MHz, DMSO-D6) 37.1 (2C), 126.8 (2C), 130.6 (2C), 134.1 (2C), 172.4 (2C).
	With sulfuric acid; water; for 2h;Heating / reflux;	Example 1; Preparation of 1,2-Phenylenediacetic acid (compound 2); In a round-bottomed flask, fitted with a reflux condenser, 10 g of phenylenediacetonitrile and 180 g of 50% sulphuric acid were refluxed for 2 h. The reaction mixture was cooled on ice to yield (2) as white crystals. Yield 11.4 g. This compound was used without further purification.

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P233	Keep container tightly closed.
P234	Keep only in original container.
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P401
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Disposal
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P501	Dispose of contents/container to ...
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CAS No.: 7500-53-0

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CAS No.: 7500-53-0

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Product Details of o-Phenylenediacetic acid

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Application In Synthesis of o-Phenylenediacetic acid

[ 7500-53-0 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed