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Chemical Structure| 803712-67-6 Chemical Structure| 803712-67-6

Structure of Obatoclax
CAS No.: 803712-67-6

Chemical Structure| 803712-67-6

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Obatoclax, a Bcl-2 homology domain-3 mimetic, antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 μMol/L), including Mcl-1 (IC50, 2.9 μMol/L) and Bfl-1 (IC50, 5 μMol/L).

Synonyms: GX15-070

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Product Details of Obatoclax

CAS No. :803712-67-6
Formula : C20H19N3O
M.W : 317.38
SMILES Code : COC1=CC(C(N2)=CC3=C2C=CC=C3)=N/C1=C\C4=C(C)C=C(C)N4
Synonyms :
GX15-070
MDL No. :MFCD09833233

Safety of Obatoclax

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Mz-ChA-1 cells 5-100 nM 48 hours Inhibition of colony formation, induction of apoptosis Cancer Res. 2010 Mar 1;70(5):1960-9.
KMCH cells 400 nM and above 48 hours Inhibition of colony formation Cancer Res. 2010 Mar 1;70(5):1960-9.
BDEneu cells 200 nM 48 hours Inhibition of colony formation, induction of apoptosis Cancer Res. 2010 Mar 1;70(5):1960-9.
HuCCT-1 cells 5-100 nM 48 hours Inhibition of colony formation, induction of apoptosis Cancer Res. 2010 Mar 1;70(5):1960-9.
H460 NSCLC cells 500 nM 6, 24, 48 hours Obatoclax disrupts BAK/MCL-1 complex Cell Death Dis. 2010 Dec 16;1(12):e108.
5637 cells 28 nM (IC50) 1, 3, 5 days Obatoclax inhibits cell proliferation and clonogenicity, and promotes apoptosis in a dose-dependent manner Int J Mol Sci. 2019 Mar 14;20(6):1285.
TCCSuP cells 70 nM (IC50) 1, 3, 5 days Obatoclax inhibits cell proliferation and clonogenicity, and promotes apoptosis in a dose-dependent manner Int J Mol Sci. 2019 Mar 14;20(6):1285.
T24 cells 20 nM (IC50) 1, 3, 5 days Obatoclax inhibits cell proliferation and clonogenicity, and promotes apoptosis in a dose-dependent manner Int J Mol Sci. 2019 Mar 14;20(6):1285.
TFK-1 0.5 µM 16 hours Obatoclax induced minimal apoptosis alone; however, it increased apoptosis 3- to 13-fold in all three cancer cell lines when combined with Apo2L/TRAIL. Mol Cancer Ther. 2008 Aug;7(8):2339-47.
KMBC 0.5 µM 16 hours Obatoclax induced minimal apoptosis alone; however, it increased apoptosis 3- to 13-fold in all three cancer cell lines when combined with Apo2L/TRAIL. Mol Cancer Ther. 2008 Aug;7(8):2339-47.
KMCH 0.5 µM 16 hours Obatoclax induced minimal apoptosis alone; however, it increased apoptosis 3- to 13-fold in all three cancer cell lines when combined with Apo2L/TRAIL. Mol Cancer Ther. 2008 Aug;7(8):2339-47.
AML CD34+ progenitor cells 250 nM - 10 µM 24 hours Obatoclax induced apoptosis in AML CD34+ progenitor cells with an average IC50 of 3.59 μM. Cancer Res. 2008 May 1;68(9):3413-20.
KTC-1 cells 1 µM to 10 µM 24 hours Obatoclax induced massive apoptosis of KTC-1 cells in a dose-dependent manner, and caused loss of mitochondrial membrane potential, dysfunction of mitochondrial respiration, reduction of cellular glycolysis, autophagy, neutralization of lysosomes, and caspase-related apoptosis. Theranostics. 2017 Feb 23;7(4):987-1001.
BCPAP cells 1 µM to 10 µM 24 hours Obatoclax induced massive apoptosis of BCPAP cells in a dose-dependent manner, and caused loss of mitochondrial membrane potential, dysfunction of mitochondrial respiration, reduction of cellular glycolysis, autophagy, neutralization of lysosomes, and caspase-related apoptosis. Theranostics. 2017 Feb 23;7(4):987-1001.
K1 cells 1 µM to 10 µM 24 hours Obatoclax induced massive apoptosis of K1 cells in a dose-dependent manner, and caused loss of mitochondrial membrane potential, dysfunction of mitochondrial respiration, reduction of cellular glycolysis, autophagy, neutralization of lysosomes, and caspase-related apoptosis. Theranostics. 2017 Feb 23;7(4):987-1001.
Karpas-422 cells 100 nM 24 hours Obatoclax in combination with VSV activated the mitochondrial apoptotic pathway in Karpas-422 cells, leading to caspase-3 and -9 cleavage, cytochrome c release, and BAX translocation. Mol Ther. 2010 Dec;18(12):2094-103.
CD5+ CD19+ CLL cells 100 nM 24 hours Obatoclax in combination with VSV synergistically induced cell death in primary CLL cells, significantly increasing cell mortality. Mol Ther. 2010 Dec;18(12):2094-103.
BxPC-3 0–2.5 µM 24 hours Obatoclax alone or in combination with TRAIL significantly enhanced apoptosis in BxPC-3 cells, as evidenced by increased Annexin V labeling, accompanied by activation of caspase-8, -9, and -3 and cleavage of Bid. Clin Cancer Res. 2009 Jan 1;15(1):150-9.
PANC-1 0–2.5 µM 24 hours Obatoclax alone or in combination with TRAIL significantly enhanced apoptosis in PANC-1 cells, as evidenced by increased Annexin V labeling, accompanied by activation of caspase-8, -9, and -3 and cleavage of Bid. Clin Cancer Res. 2009 Jan 1;15(1):150-9.
Caco-2 0.33, 1 µM, 3.3 µM 24 hours Evaluate the inhibitory effect of Obatoclax on clinical SARS-CoV-2 isolate infections Emerg Microbes Infect. 2022 Dec;11(1):483-497.
Calu-3 0.33, 1 µM, 3.3 µM 24 hours Evaluate the inhibitory effect of Obatoclax on clinical SARS-CoV-2 isolate infections Emerg Microbes Infect. 2022 Dec;11(1):483-497.
H69 200 nM 24 hours Synergistic growth inhibition of SCLC cells and reduction of MCL-1 expression Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.
H1963 200 nM 24 hours Synergistic growth inhibition of SCLC cells and reduction of MCL-1 expression Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.
H196 200 nM 24 hours Synergistic growth inhibition of SCLC cells and reduction of MCL-1 expression Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.
DMS79 200 nM 24 hours Synergistic growth inhibition of SCLC cells and reduction of MCL-1 expression Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.
H526 200 nM 24 hours Synergistic growth inhibition of SCLC cells and reduction of MCL-1 expression Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.
H82 200 nM 24 hours Synergistic growth inhibition of SCLC cells and reduction of MCL-1 expression Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.
CT26 cells 10 µM or 30 µM 24 hours To evaluate the inhibitory effect of Obatoclax on the migration of CT26 cells. Results showed that Obatoclax significantly inhibited the migration of CT26 cells at concentrations as low as 0.01 µM. J Transl Med. 2024 Mar 30;22(1):321.
IPSC-derived neurons with P525L FUS-eGFP 10 nM 24 hours Assessed p62 protein levels and found that obatoclax reduced p62 levels, ameliorating defects in protein homeostasis. Cells. 2023 Sep 11;12(18):2247.
IPSC-derived neurons with P525L FUS-eGFP 10 nM 24 hours Quantified cytoplasmic FUS levels via immunostaining and found that obatoclax significantly reduced cytoplasmic FUS levels. Cells. 2023 Sep 11;12(18):2247.
IPSC-derived neurons with P525L FUS-eGFP 1, 10, 100, 1000, 10000 nM 24 hours Assessed cell viability and found that obatoclax at 10 nM significantly reduced the formation of FUS-eGFP-positive stress granules. Cells. 2023 Sep 11;12(18):2247.
CHLA05-ATRT 40 nM 24 hours To evaluate the effect of Obatoclax on apoptosis and oxidative stress, results showed that Obatoclax significantly induced oxidative stress and apoptosis. Cell Death Dis. 2022 Apr 28;13(4):410.
CHLA02-ATRT 40 nM 24 hours To evaluate the effect of Obatoclax on apoptosis and oxidative stress, results showed that Obatoclax significantly induced oxidative stress and apoptosis. Cell Death Dis. 2022 Apr 28;13(4):410.
BT37 40 nM 24 hours To evaluate the effect of Obatoclax on apoptosis and oxidative stress, results showed that Obatoclax significantly induced oxidative stress and apoptosis. Cell Death Dis. 2022 Apr 28;13(4):410.
CHLA06-ATRT 40 nM 24 hours To evaluate the effect of Obatoclax on apoptosis and oxidative stress, results showed that Obatoclax significantly induced oxidative stress and apoptosis. Cell Death Dis. 2022 Apr 28;13(4):410.
BT-12 40 nM 24 hours To evaluate the effect of Obatoclax on apoptosis and oxidative stress, results showed that Obatoclax significantly induced oxidative stress and apoptosis. Cell Death Dis. 2022 Apr 28;13(4):410.
Human melanoma cells (Mel-RM and MM200) 100 nM to 1 µM 24 or 48 hours Obatoclax as a single agent at nanomolar concentrations was relatively ineffective in inducing apoptosis, but when combined with ER stress inducers like tunicamycin or thapsigargin, it markedly enhanced apoptotic cell death. Neoplasia. 2009 Sep;11(9):945-55.
CT26 cells 30 µM to 0.3 µM 24, 48, and 72 hours To evaluate the inhibitory effect of Obatoclax on the proliferation of CT26 cells. Results showed that Obatoclax significantly inhibited the growth of CT26 cells at lower concentrations. J Transl Med. 2024 Mar 30;22(1):321.
KG-1 0.5, 1, 2.5, 5, 10 µM 24-72 hours Obatoclax inhibited KG-1 cell growth and induced apoptosis. Cancer Res. 2008 May 1;68(9):3413-20.
OCI-AML3 0.5, 1, 2.5, 5, 10 µM 24-72 hours Obatoclax inhibited OCI-AML3 cell growth and induced apoptosis, accompanied by S/G2 cell cycle arrest. Cancer Res. 2008 May 1;68(9):3413-20.
U937 0.5, 1, 2.5, 5, 10 µM 24-72 hours Obatoclax inhibited U937 cell growth and induced apoptosis, accompanied by cytochrome C release. Cancer Res. 2008 May 1;68(9):3413-20.
HL-60 0.5, 1, 2.5, 5, 10 µM 24-72 hours Obatoclax inhibited HL-60 cell growth and induced apoptosis, accompanied by Bak release from Mcl-1 and Bim release from Bcl-2/Mcl-1. Cancer Res. 2008 May 1;68(9):3413-20.
Reh cells 100 nM 48 hours GX15-070 induces LC3 conversion and caspase-3 cleavage in Reh cells, indicating apoptosis and autophagy. Cell Death Dis. 2010 Sep 16;1(9):e76.
Jurkat cells 100 nM 48 hours GX15-070 induces LC3 conversion and caspase-3 cleavage in Jurkat cells, indicating apoptosis and autophagy. Cell Death Dis. 2010 Sep 16;1(9):e76.
HSB-2 cells 100 nM 48 hours GX15-070 induces LC3 conversion and caspase-3 cleavage in HSB-2 cells, indicating apoptosis and autophagy. Cell Death Dis. 2010 Sep 16;1(9):e76.
Molt-4 cells 100 nM 48 hours GX15-070 induces LC3 conversion and p62 degradation in Molt-4 cells, indicating autophagic cell death. Cell Death Dis. 2010 Sep 16;1(9):e76.
CCRF-CEM (CEM) T-ALL cells 100 nM 48 hours GX15-070 induces caspase-3 and PARP cleavage, increases the Annexin V-positive population, indicating apoptosis. Additionally, GX15-070 induces LC3 conversion and p62 degradation, markers of autophagic cell death. Cell Death Dis. 2010 Sep 16;1(9):e76.
Mouse embryonic fibroblasts (WT and DKO) 500 nM 48 hours Obatoclax-induced apoptosis is dependent on BAX/BAK, but loss of BAX/BAK fails to rescue cells Cell Death Dis. 2010 Dec 16;1(12):e108.
H1975 NSCLC cells 500 nM 48 hours Obatoclax induces BAK activation and mitochondrial outer membrane permeabilization Cell Death Dis. 2010 Dec 16;1(12):e108.
Melanocytes 1 µM 48 hours Obatoclax did not induce significant apoptotic cell death in melanocytes (<10% apoptotic cells). Neoplasia. 2009 Sep;11(9):945-55.
WiDr 0~400 nM 48 hours Obatoclax significantly reduced cell viability with an IC50 of 231.04±2.01 nM Int J Mol Sci. 2020 Mar 5;21(5):1773.
LoVo 0~400 nM 48 hours Obatoclax significantly reduced cell viability with an IC50 of 283.82±3.46 nM Int J Mol Sci. 2020 Mar 5;21(5):1773.
HCT 116 0~400 nM 48 hours Obatoclax significantly reduced cell viability with an IC50 of 89.96±1.68 nM Int J Mol Sci. 2020 Mar 5;21(5):1773.
DLD-1 0~400 nM 48 hours Obatoclax significantly reduced cell viability with an IC50 of 257.19±1.46 nM Int J Mol Sci. 2020 Mar 5;21(5):1773.
Caco-2-hACE2 330 nM 72 hours Evaluate the inhibitory effect of Obatoclax on SARS-CoV-2 pseudovirus entry Emerg Microbes Infect. 2022 Dec;11(1):483-497.
A549-hACE2 330 nM 72 hours Evaluate the inhibitory effect of Obatoclax on SARS-CoV-2 pseudovirus entry Emerg Microbes Infect. 2022 Dec;11(1):483-497.
Calu-3-hACE2 330 nM 72 hours Evaluate the inhibitory effect of Obatoclax on SARS-CoV-2 pseudovirus entry Emerg Microbes Infect. 2022 Dec;11(1):483-497.
HEK293T-hACE2 330 nM 72 hours Evaluate the inhibitory effect of Obatoclax on SARS-CoV-2 pseudovirus entry Emerg Microbes Infect. 2022 Dec;11(1):483-497.
AML ROS-low cells 10 µM Inhibited oxidative respiration Cell Stem Cell. 2013 Mar 7;12(3):329-41.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Fischer 344 rats Rat cholangiocarcinoma model Intravenous injection 1.5 mg/kg Once daily for 5 consecutive days Evaluate the anti-tumor effect of Obatoclax in vivo, results showed significant reduction in tumor size and prolonged survival Cancer Res. 2010 Mar 1;70(5):1960-9.
Nude mice Subcutaneous xenograft model of K1 cells Subcutaneous injection 10 mg/kg/day (single agent) or 20 mg/kg/day (combination therapy) Once daily for 21 days Obatoclax alone or in combination with Vemurafenib significantly inhibited the growth of subcutaneous xenografts of K1 cells, and the tumor volume of the combination therapy group was significantly smaller than that of the single-agent treatment group. Theranostics. 2017 Feb 23;7(4):987-1001.
BALB/c mice CT26-Luc2 colorectal liver metastasis model Intravenous injection 2 mg/kg or 5 mg/kg Once daily for 13 days To evaluate the inhibitory effect of Obatoclax on colorectal liver metastasis. Results showed that Obatoclax significantly inhibited liver metastasis at doses of 2 mg/kg and 5 mg/kg. J Transl Med. 2024 Mar 30;22(1):321.
Nude mice H82 SCLC xenograft model Intraperitoneal injection 3 mg/kg Every 3 days for 21 days Significant inhibition of SCLC tumor growth and reduction of Ki-67 proliferation marker Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.
SCID mice A20 lymphoma model Intraperitoneal injection 3 mg/kg/day Five consecutive days Obatoclax in combination with VSV significantly inhibited A20 lymphoma tumor growth in vivo, reducing tumor volume by 80%. Mol Ther. 2010 Dec;18(12):2094-103.
Nu/Nu mice CHLA06-ATRT and BT37 orthotopic xenograft models IP or oral Obatoclax 6 mg/kg IP or 10 mg/kg oral, TAK-228 6 mg/kg oral Once a week, continuous treatment To evaluate the effect of Obatoclax and TAK-228 combination therapy on tumor growth and survival, results showed that combination therapy significantly slowed tumor growth and extended median survival. Cell Death Dis. 2022 Apr 28;13(4):410.

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01150656 - Completed - -
NCT00438178 Hematological Malignancies Phase 1 Completed - United States, District of Col... More >>umbia Georgetown University Medical Center Washington, District of Columbia, United States, 20007 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00360035 Myelofibrosis Phase 2 Completed - United States, District of Col... More >>umbia Georgetown University Medical Center Washington, District of Columbia, United States, 20007 United States, Florida James A. Haley Veterans Hospital Tampa, Florida, United States, 33612 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Illinois The University of Chicago Chicago, Illinois, United States, 60637 United States, Massachusetts University of Massachusetts Medical Center Worcester, Massachusetts, United States, 01655 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00724841 Metastatic Melanoma Phase 1 Phase 2 Terminated(Study terminated pr... More >>ematurely due to financial contraints.) Less << - United States, Pennsylvania ... More >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00521144 Recurrent Small Cell Lung Canc... More >>er Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 1 Phase 2 Completed - United States, Maryland ... More >> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital Baltimore, Maryland, United States, 21231 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less <<
NCT01238146 Extranodal Marginal Zone B-cel... More >>l Lymphoma of Mucosa-associated Lymphoid Tissue Nodal Marginal Zone B-cell Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Splenic Marginal Zone Lymphoma Less << Phase 1 Phase 2 Withdrawn(No patients accrued.... More >>) Less << - United States, Ohio ... More >> Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less <<
NCT00521144 - Completed - -
NCT00719901 Refractory Multiple Myeloma ... More >> Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Multiple Myeloma Less << Phase 1 Phase 2 Terminated(This trial was term... More >>inated due to slow accrual and the drug supply of Obatoclax during the phase I; therefore, the phase II portion will never open.) Less << - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00413114 Myelodysplastic Syndromes Phase 2 Completed - -
NCT00405951 Lung Cancer Phase 1 Phase 2 Completed - United States, Arizona ... More >> Mayo Clinic College of Medicine Scottsdale, Arizona, United States, 85259 United States, California Tower Oncology Beverly Hills, California, United States, 90210 United States, District of Columbia Georgetown University Washington, District of Columbia, United States, 20007 United States, Florida H. Lee Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Maryland University of Maryland Baltimore, Maryland, United States, 21201 MedStar Research Institute Baltimore, Maryland, United States, 21225 United States, Texas Arlington Cancer Center Arlington, Texas, United States, 76012 Less <<
NCT01563601 Extensive-stage Small Cell Lun... More >>g Cancer Less << Phase 3 Withdrawn(Business Decision) January 2018 -
NCT00407303 Mantle-Cell Lymphoma Phase 1 Phase 2 Completed - United States, Georgia ... More >> NW Georgia Oncology Centers Marietta, Georgia, United States, 30060 United States, Illinois Northwestern University Feinberg School of Medicine Chicago, Illinois, United States, 60611 United States, New Jersey Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, New York Roswell Park Medical Center Buffalo, New York, United States, 14263 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53792 Less <<
NCT00359892 Hodgkin's Lymphoma Phase 2 Completed - United States, Texas ... More >> MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00918931 - Terminated - -
NCT00719901 - Terminated(This trial was term... More >>inated due to slow accrual and the drug supply of Obatoclax during the phase I; therefore, the phase II portion will never open.) Less << - -
NCT00612612 B-cell Chronic Lymphocytic Leu... More >>kemia Leukemia Prolymphocytic Leukemia Refractory Chronic Lymphocytic Leukemia Stage I Chronic Lymphocytic Leukemia Stage II Chronic Lymphocytic Leukemia Stage III Chronic Lymphocytic Leukemia Stage IV Chronic Lymphocytic Leukemia Less << Phase 1 Terminated - United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less <<
NCT00918931 Leukemia Syst... More >>emic Mastocytosis Less << Phase 2 Terminated - United States, Texas ... More >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00427856 Lymphoma, Follicular Phase 2 Completed - United States, New Jersey ... More >> The Cancer Center at Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 Less <<
NCT00600964 Chronic Lymphocytic Leukemia Phase 1 Completed - United States, California ... More >> University of CA- San Diego La Jolla, California, United States, 92093 United States, District of Columbia Lombardi Cancer Center Washington, District of Columbia, United States, 20007 United States, Pennsylvania Milton S Hershey Medical Center Penn State Cancer Institute Hershey, Pennsylvania, United States, 17033 United States, Texas UT MD Anderson Cancer Center Houston, Texas, United States, 77030 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00933985 Acute Leukemias of Ambiguous L... More >>ineage Acute Undifferentiated Leukemia Angioimmunoblastic T-cell Lymphoma Blastic Phase Chronic Myelogenous Leukemia Childhood Burkitt Lymphoma Childhood Chronic Myelogenous Leukemia Childhood Diffuse Large Cell Lymphoma Childhood Immunoblastic Large Cell Lymphoma Childhood Nasal Type Extranodal NK/T-cell Lymphoma Cutaneous B-cell Non-Hodgkin Lymphoma Hepatosplenic T-cell Lymphoma Intraocular Lymphoma Noncutaneous Extranodal Lymphoma Peripheral T-cell Lymphoma Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Recurrent Childhood Anaplastic Large Cell Lymphoma Recurrent Childhood Grade III Lymphomatoid Granulomatosis Recurrent Childhood Large Cell Lymphoma Recurrent Childhood Lymphoblastic Lymphoma Recurrent Childhood Small Noncleaved Cell Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent/Refractory Childhood Hodgkin Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Relapsing Chronic Myelogenous Leukemia Small Intestine Lymphoma Unspecified Childhood Solid Tumor, Protocol Specific Less << Phase 1 Terminated - -
NCT00684918 AML PHASE2 COMPLETED 2025-12-09 Northwestern University, Chica... More >>go, Illinois, 60611, United States|The University of Iowa, Iowa City, Iowa, 52242, United States|University of Kansas Medical Center Research Institute, Westwood, Kansas, 66205, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States|St. Joseph Mercy Hospital, Ann Arbor, Michigan, 48106, United States|University of Michigan Health System, Ann Arbor, Michigan, 48109, United States|Michigan State University - Breslin Cancer Center, Lansing, Michigan, 48910, United States|St. Vincent's Comprehensive Cancer Center, New York, New York, 10011, United States|Legacy Emanuel Hospital & Health Center, Portland, Oregon, 97210, United States|Penn State Hershey Cancer Institute-Clinical Trials Office, Hershey, Pennsylvania, 17033, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Benaroya Research Institute at Virginia Mason, Seattle, Washington, 98101, United States|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada Less <<
NCT00538187 Adult Non-Hodgkin Lymphoma ... More >> Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Small Lymphocytic Lymphoma Less << Phase 1 Terminated - United States, California ... More >> City of Hope Medical Center Duarte, California, United States, 91010 Less <<
NCT00682981 Extensive-stage Small Cell Lun... More >>g Cancer Less << Phase 1 Phase 2 Completed - -

Protocol

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