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Chemical Structure| 1357302-64-7 Chemical Structure| 1357302-64-7

Structure of OG-L002
CAS No.: 1357302-64-7

Chemical Structure| 1357302-64-7

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OG-L002 is a selective inhibitor of LSD1 with IC50 of 20 nM.

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Product Details of OG-L002

CAS No. :1357302-64-7
Formula : C15H15NO
M.W : 225.29
SMILES Code : OC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1
MDL No. :MFCD27997969
InChI Key :DSOJSZXQRJGBCW-CABCVRRESA-N
Pubchem ID :56639570

Safety of OG-L002

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of OG-L002

epigenetics

Isoform Comparison

Biological Activity

Target
  • KDM1

    LSD1, IC50:20 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
Vero cells 60 µM 24 hours Measure cytotoxicity of OG-L002 on Vero cells J Virol. 2020 Sep 15;94(19):e00974-20.
MRC-5 cells 60 µM 24 hours Measure cytotoxicity of OG-L002 on MRC-5 cells J Virol. 2020 Sep 15;94(19):e00974-20.
Koi Fin (KF-1) cells 20 µM and 50 µM 24 hours OG-L002 at 20 µM and 50 µM produced 96% and 98% inhibition, respectively. Viruses. 2023 Jan 5;15(1):163.
Peripheral blood leukocytes 50 µM 24 hours To test the effect of OG-L002 on EHV-1 viral load, results showed that OG-L002 did not suppress EHV-1 viral load in leukocytes. Front Vet Sci. 2018 Mar 12;5:34.
Equine fetal kidney cells (EFKCs) 50 µM 24 hours To test the effect of OG-L002 on EHV-1 viral load, results showed that OG-L002 alone significantly reduced EHV-1 viral load. Front Vet Sci. 2018 Mar 12;5:34.
PANC-1 cells 50 µM 8 days Inhibited growth of PDAC cells under glycolysis-suppressed conditions Cell Death Discov. 2024 Apr 5;10(1):166.

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.44mL

0.89mL

0.44mL

22.19mL

4.44mL

2.22mL

44.39mL

8.88mL

4.44mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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