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Chemical Structure| 879562-26-2 Chemical Structure| 879562-26-2

Structure of 879562-26-2

Chemical Structure| 879562-26-2

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Synonyms: Dehydro Olmesartan medoxomil

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of [ 879562-26-2 ]

CAS No. :879562-26-2
Formula : C29H28N6O5
M.W : 540.57
SMILES Code : O=C(C1=C(C(C)=C)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)OCC5=C(C)OC(O5)=O
Synonyms :
Dehydro Olmesartan medoxomil
MDL No. :MFCD16660960

Safety of [ 879562-26-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H228-H315-H319
Precautionary Statements:P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:4.1
UN#:1325
Packing Group:

Application In Synthesis of [ 879562-26-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 879562-26-2 ]

[ 879562-26-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 144689-63-4 ]
  • [ 879562-26-2 ]
YieldReaction ConditionsOperation in experiment
(Production of impurity sample) (Olmesartan medoxomil dehydrate (Compound B)) (5-Methyl-2-oxo-1,3-dioxolcn-4-yl)methyl 4-(1-hydroxy-l-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylate [<strong>[144689-63-4]olmesartan medoxomil</strong>] (20.0 g) was added into anhydrous N,N-dimethylacetamide (80 ml) under a nitrogen stream, and after dissolution was confirmed, concentrated sulfuric acid (3.0 ml) was poured in and the mixture was reacted at about 100C for 2.5 hours. Upon completion of the reaction, the reaction mixture was cooled to about 40C and poured into cold water (80 ml). After methylene chloride (80 ml) was poured in, the pH of the reaction mixture was adjusted to 4.2 with 25% sodium hydroxide, The organic layer was separated, washed with brine (80 ml) and concentrated under reduced pressure to obtain 22.58 g of (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-isopropenyl-2-propyl-1-[[2'-[1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate [crude <strong>[144689-63-4]olmesartan medoxomil</strong> dehydrate] as a foam. The obtained crude <strong>[144689-63-4]olmesartan medoxomil</strong> dehydrate was dissolved in methylene chloride (45 ml) and adsorbed onto silica gel (340 g), and separated by silica gel chromatography using a solvent system of methylene chloride and ethanol with a mixing ratio of 99:1 to 99:5, and the eluent was concentrated under reduced pressure to obtain 7.84 g of high-quality <strong>[144689-63-4]olmesartan medoxomil</strong> dehydrate (Compound B). Mass spectrum (FAB) m/z: 541 (M+H)+ 1H-NMR spectrum (DMSO-d6):delta ppm 0.87(3H, t, J=7.3 Hz), 1.53-1.63(2H, m), 2.02(3H, s), 2.11(3H, s), 2.58(2H, t, J=7.6 Hz), 5.03(2H, s), 5,18(1H, s), 5.24(1H, s), 5.45(2H, s), 6.92(2H, d, J=8.1 Hz), 7,05(2H, d, J=8.1 Hz), 7.52-7.68(4H, m)
 

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