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Chemical Structure| 1034616-18-6 Chemical Structure| 1034616-18-6

Structure of Onvansertib
CAS No.: 1034616-18-6

Chemical Structure| 1034616-18-6

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NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC50=2 nM) with potential antineoplastic activity and no inhibition on PLK2 and PLK3.

Synonyms: NMS-P937; Nms-1286937; PCM-075

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Product Details of Onvansertib

CAS No. :1034616-18-6
Formula : C24H27F3N8O3
M.W : 532.52
SMILES Code : O=C(C1=NN(CCO)C2=C1CCC3=CN=C(NC4=CC(N5CCN(C)CC5)=CC=C4OC(F)(F)F)N=C23)N
Synonyms :
NMS-P937; Nms-1286937; PCM-075
MDL No. :MFCD26793840
InChI Key :QHLVBNKYJGBCQJ-UHFFFAOYSA-N
Pubchem ID :49792852

Safety of Onvansertib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • PLK1

    PLK1, IC50:2 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05450965 Small-cell Lung Cancer|Small C... More >>ell Lung Carcinoma Less << PHASE2 RECRUITING 2027-11-30 University of Maryland Greeneb... More >>aum Comprehensive Cancer Center, Baltimore, Maryland, 21201, United States|UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, 15232, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.88mL

0.38mL

0.19mL

9.39mL

1.88mL

0.94mL

18.78mL

3.76mL

1.88mL

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