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CAS No. :	480-11-5
Formula :	C₁₆H₁₂O₅
M.W :	284.26
SMILES Code :	COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=CC=C3)O
Synonyms :	Baicalein 6-methyl ether; 6-Methoxybaicalein
MDL No. :	MFCD02259441
InChI Key :	LKOJGSWUMISDOF-UHFFFAOYSA-N
Pubchem ID :	5320315

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

MCF-7 cells	100 µM	10 hours	Inhibited glycolysis via upregulation of SIRT3	Cell Death Dis. 2015 Apr 9;6(4):e1714
HCT116 cells	100 and 200 μΜ	48 hours	Inhibited glucose uptake and lactate production	J Hematol Oncol. 2015 Apr 23;8:41
MCF-7 cells	100 and 200 μΜ	48 hours	Inhibited glucose uptake and lactate production	J Hematol Oncol. 2015 Apr 23;8:41
MDA-MB-231 cells	100 µM	10 hours	Inhibited glycolysis via upregulation of SIRT3 and SIRT3-mediated destabilization of HIF1α	Cell Death Dis. 2015 Apr 9;6(4):e1714
Uterine strips from non-pregnant female Wistar rats	1~100 µM	10 minutes	To investigate the inhibitory effect of Oroxylin A on uterine contractions induced by high potassium (KCl 56.3 mM). Results showed that Oroxylin A significantly inhibited high potassium-induced contractions, with an IC50 value of 12.58 μM.	J Biomed Sci. 2009 Mar 4;16(1):27
Uterine strips from non-pregnant female Wistar rats	1~100 µM	10 minutes	To investigate the effect of Oroxylin A on oxytocin-induced uterine contractions in a calcium-free solution. Results showed that Oroxylin A had no significant inhibitory effect on calcium release induced by oxytocin.	J Biomed Sci. 2009 Mar 4;16(1):27
Uterine strips from non-pregnant female Wistar rats	1~100 µM	10 minutes	To investigate the inhibitory effects of Oroxylin A on uterine contractions induced by acetylcholine (Ach), prostaglandin F2α (PGF2α), and oxytocin. Results showed that Oroxylin A significantly inhibited contractions induced by these agonists, with IC50 values of 22.85 μM, 27.28 μM, and 12.34 μM, respectively.	J Biomed Sci. 2009 Mar 4;16(1):27
HepG2 cells	0-200 µM	12, 24, 48, 72 hours	To evaluate the effect of Oroxylin A on HepG2 cell proliferation, results showed it inhibited cell proliferation in a time- and dose-dependent manner, with IC50 values of 17.2 and 6.8 μM at 48 and 72 h, respectively.	Clin Transl Med. 2022 Nov;12(11):e1095
Human HSC line LX2 cells	30 and 40 µM	24 hours	Oroxylin A significantly inhibited HSC contraction, reduced the formation of actin stress fibers, and decreased the phosphorylation levels of myosin light chain 2 (MLC2).	Cell Commun Signal. 2019 Feb 11;17(1):11
HCT116 cells	25, 50, 100, 150 µM	36 hours	Oroxylin A reprogrammed fatty acid metabolism of HCT116 cells by inactivating HIF1α, decreasing intracellular fatty acid level and enhancing fatty acid oxidation.	Cell Death Dis. 2017 Jun 8;8(6):e2865
MCF-7 cells	100-200 µM	48 hours	Inhibited glycolysis, decreased glucose uptake, lactate production, ATP generation, and mitochondrial membrane potential (MMP)	Cell Death Dis. 2013 Apr 18;4(4):e601
MDA-MB-231 cells	100-200 µM	48 hours	Inhibited glycolysis, decreased glucose uptake, lactate production, ATP generation, and mitochondrial membrane potential (MMP)	Cell Death Dis. 2013 Apr 18;4(4):e601
H1299 cells	200 μΜ	48 hours	Only cells expressing wt-p53 cDNA showed decreased glycolysis, while cells transfected with mut-p53 cDNA were resistant to oroxylin A's effects	J Hematol Oncol. 2015 Apr 23;8:41
MHCC-97H cells	16, 32, 64 µM	48 hours	To evaluate the inhibitory effect of Oroxylin A on cell growth, results showed that Oroxylin A significantly inhibited the growth of MHCC-97H cells.	Redox Biol. 2020 Jan;29:101392
HepG2 cells	16, 32, 64 µM	48 hours	To evaluate the inhibitory effect of Oroxylin A on cell growth, results showed that Oroxylin A significantly inhibited the growth of HepG2 cells.	Redox Biol. 2020 Jan;29:101392
SMMC-7721 cells	16, 32, 64 µM	48 hours	To evaluate the inhibitory effect of Oroxylin A on cell growth, results showed that Oroxylin A significantly inhibited the growth of SMMC-7721 cells.	Redox Biol. 2020 Jan;29:101392
L02 cells	0-100 µM	48 hours	To evaluate the effect of Oroxylin A on L02 cell proliferation, results showed no obvious toxicity to normal cells.	Clin Transl Med. 2022 Nov;12(11):e1095
Hep1-6 cells	0-100 µM	48 hours	To evaluate the effect of Oroxylin A on Hep1-6 cell proliferation, results showed it significantly inhibited cell proliferation.	Clin Transl Med. 2022 Nov;12(11):e1095
SK-hep-1 cells	0-100 µM	48 hours	To evaluate the effect of Oroxylin A on SK-hep-1 cell proliferation, results showed it significantly inhibited cell proliferation.	Clin Transl Med. 2022 Nov;12(11):e1095
Hep3B cells	0-100 µM	48 hours	To evaluate the effect of Oroxylin A on Hep3B cell proliferation, results showed it significantly inhibited cell proliferation.	Clin Transl Med. 2022 Nov;12(11):e1095
Huh-7 cells	0-100 µM	48 hours	To evaluate the effect of Oroxylin A on Huh-7 cell proliferation, results showed it significantly inhibited cell proliferation.	Clin Transl Med. 2022 Nov;12(11):e1095
SMMC-7721 cells	0-100 µM	48 hours	To evaluate the effect of Oroxylin A on SMMC-7721 cell proliferation, results showed it significantly inhibited cell proliferation.	Clin Transl Med. 2022 Nov;12(11):e1095
SMMC-7721 cells	0, 6.25, 12.5, 25, 50 µM	48 hours	To evaluate the effect of OA on the viability of HCC cells. OA did not induce significant cytotoxicity within 48 hours.	Acta Pharmacol Sin. 2022 Mar;43(3):724-734
SMMC-7721 cells	50 µM	48 hours	To evaluate the inhibitory effect of OA on TGF-β1-induced migration and invasion of HCC cells. OA significantly suppressed TGF-β1-induced migration and invasion of HCC cells.	Acta Pharmacol Sin. 2022 Mar;43(3):724-734
HepG2 cells	15 µM	48 hours	Inhibition of CDK9 activity, increased wt-p53 protein levels	Acta Pharmacol Sin. 2022 Apr;43(4):1033-1045
Osteoclast precursors	5 µM	5 days	Assess the inhibitory effect of OAPLG on osteoclast differentiation, showing OAPL and OAPLG groups significantly reduced the number and area of TRAP-positive multinucleated osteoclasts.	J Nanobiotechnology. 2024 Apr 5;22(1):153
Bone marrow macrophages (BMMs)	5 µM	72 hours	Evaluate the cytotoxic effect of ORO on BMMs proliferation, showing no significant impact on cell viability at 5 μM.	J Nanobiotechnology. 2024 Apr 5;22(1):153

C57BL/6 mice	Ovariectomy-induced osteoporosis model	Intravenous injection	0.1 mg/kg	Every two weeks for two months	Evaluate the therapeutic effect of OAPLG on osteoporosis, showing significant improvement in trabecular microstructure and bone volume, and reduced expression of bone resorption marker CTX-1.	J Nanobiotechnology. 2024 Apr 5;22(1):153
Nude mice	MCF-7 or HCT116 xenograft tumor model	Intravenous injection	100 mg/kg	Every 2 days for 21 days	Inhibited tumor growth of MCF-7 or HCT116 xenografts and downregulated MDM2 protein expression in tumor tissues	J Hematol Oncol. 2015 Apr 23;8:41
Nude mice	HCT116 xenograft model	Oral	150 and 300 mg/kg	Every 2 days for 21 days	Oroxylin A significantly inhibited the growth of colon cancer xenografts with inhibitory rates of 36.3±2.33% and 47.0±5.35%, respectively.	Cell Death Dis. 2017 Jun 8;8(6):e2865
BALB/c nude mice	HepG2 xenograft model	Intraperitoneal injection	20, 40, 80 mg/kg/day	Once daily for 12 days	To evaluate the inhibitory effect of Oroxylin A on HepG2 xenograft tumours, results showed it significantly inhibited tumour growth, with tumour growth inhibition rates of 37.78%, 44.02%, and 54.96%, respectively.	Clin Transl Med. 2022 Nov;12(11):e1095
Nude mice	HepG2 xenograft model	Intragastric administration	300 mg/kg	Once every 2 days for 22 days	Inhibition of tumor growth, increased wt-p53 protein levels	Acta Pharmacol Sin. 2022 Apr;43(4):1033-1045
ICR mice	Carbon tetrachloride-induced hepatic fibrosis model	Oral	40 mg/kg	Once daily for 4 weeks	Oroxylin A alleviated liver injury and fibrosis, inhibited HSC glycolysis and contraction, and these effects were dependent on inhibition of LDH-A.	Cell Commun Signal. 2019 Feb 11;17(1):11
Female athymic BALB/c nude mice	Transplanted human breast tumor model	Intravenous injection	50 mg/kg and 100 mg/kg	Every 2 days for 21 days	Inhibited tumor growth associated with glycolytic suppression	Cell Death Dis. 2015 Apr 9;6(4):e1714

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CAS No.: 480-11-5

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CAS No.: 480-11-5

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed