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Chemical Structure| 15646-46-5 Chemical Structure| 15646-46-5

Structure of Oxazolone
CAS No.: 15646-46-5

Chemical Structure| 15646-46-5

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Oxazolone is a hapten that induces acute or chronic colitis, commonly used in constructing colitis models. It induces Th1/Th2 dependent colitis associated with weight loss and diarrhea, which can be alleviated by anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2α-Fc protein.

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Product Details of Oxazolone

CAS No. :15646-46-5
Formula : C12H11NO3
M.W : 217.22
SMILES Code : O=C(OC(C1=CC=CC=C1)=N2)C2=COCC
MDL No. :MFCD00003204

Safety of Oxazolone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317
Precautionary Statements:P280

Isoform Comparison

Biological Activity

Description
Oxazolone acts as a haptenizing agent that triggers acute or chronic inflammation in the large intestine, making it suitable for developing colitis models. It leads to Th1/Th2-dependent colitis characterized by weight loss and diarrhea. The inflammation caused by oxazolone can be alleviated with neutralizing antibodies against IL-4 or TNF-α or with decoy IL-13R2-α-FC proteins[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.60mL

0.92mL

0.46mL

23.02mL

4.60mL

2.30mL

46.04mL

9.21mL

4.60mL

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