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Chemical Structure| 28721-07-5 Chemical Structure| 28721-07-5

Structure of Oxcarbazepine
CAS No.: 28721-07-5

Chemical Structure| 28721-07-5

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Oxcarbazepine is a voltage-gated sodium channel blocker with IC50 of 160 μM and it is used for the treatment of partial seizure.

Synonyms: GP 47680

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Product Details of Oxcarbazepine

CAS No. :28721-07-5
Formula : C15H12N2O2
M.W : 252.27
SMILES Code : O=C(N1C2=CC=CC=C2CC(C3=CC=CC=C31)=O)N
Synonyms :
GP 47680
MDL No. :MFCD00865307
InChI Key :CTRLABGOLIVAIY-UHFFFAOYSA-N
Pubchem ID :34312

Safety of Oxcarbazepine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • Sodium Channel

    sodium channel, IC50:160 μM

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Male Wistar albino rats Epilepsy model Intranasal administration 0.32 mg/kg Single dose Evaluate the delivery of oxcarbazepine from intranasal administration to the brain. Results showed that oxcarbazepine emulsomal thermogel significantly increased systemic absorption but did not improve brain Cmax and AUC. However, the emulsomal thermogel extended the presence of OX in the brain to up to 48 h. Pharmaceutics. 2018 Nov 5;10(4):217
Mice Maximal electroshock model Intraperitoneal injection 12.9 mg/kg (ED50) and 19.9 mg/kg (ED50) Four treatment protocols: 1. Once daily for one week (7×1); 2. Twice daily for one week (7×2); 3. Once daily for two weeks (14×1); 4. Twice daily for two weeks (14×2) To assess the impact of acute and chronic treatment with oxcarbazepine on its anticonvulsant activity, neurological adverse effects, and protective index in mice. Results showed that two weeks of oxcarbazepine treatment significantly reduced its anticonvulsant and neurotoxic effects. Int J Mol Sci. 2024 Jun 19;25(12):6751

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00154323 Bipolar Disorder PHASE4 COMPLETED 2025-01-06 -
NCT00616681 Seizures|Epilepsy COMPLETED 2025-07-04 MDS Pharma Services, Montreal,... More >> Quebec, H4R 2N6, Canada Less <<
NCT00616863 Epilepsy|Seizures COMPLETED 2025-07-04 MDS Pharma Services, Montreal,... More >> Quebec, H4R 2N6, Canada Less <<
NCT02456896 Bipolar Disorder PHASE4 COMPLETED 2025-12-15 All India Institute of Medical... More >> Sciences (AIIMS), Bhubaneswar, Odisha, 751019, India Less <<
NCT01702623 Seizures PHASE1 COMPLETED 2025-09-09 Worldwide Clinical Trials Drug... More >> Development Solutions (formerly CEDRA Clinical Research), San Antonio, Texas, 78217, United States Less <<
NCT00275925 Epilepsy, Partial Seizures PHASE4 COMPLETED 2025-03-07 Epilepsy Department of the Mos... More >>cow Research Institute of Psychiatry, Moscow, Russian Federation|Neurology and Neurosurgery Department of the Moscow State Medico-stomatology University, Moscow, Russian Federation|Neurology and Neurosurgery Department of the Russian State Medical University, Moscow, Russian Federation|Neurology Department of I.M. Sechenov Moscow Medical Academy, Moscow, Russian Federation|Neurology Department of Pediatric faculty of the Russian State Medical University, Moscow, Russian Federation|Neurology Department of the Moscow region Research Institute named after M.F. Vladimirskiy, Moscow, Russian Federation|Epilepsy Department of the V.M. Bekhterev Sant-Petersburg Psychoneurology Institute, Saint Petersburg, Russian Federation Less <<
NCT01703468 Seizures PHASE1 COMPLETED 2025-10-09 Worldwide Clinical Trials Drug... More >> Development Solutions (formerly CEDRA Clinical Research), San Antonio, Texas, 78217, United States Less <<
NCT00618046 Seizures|Epilepsy COMPLETED 2025-11-04 Bio-Kinetics Clinical Applicat... More >>ions, Inc ., Springfield, Missouri, 658902, United States Less <<
NCT01302275 Polyneuropathy|Peripheral Nerv... More >>e Injury|Postherpetic Neuralgia Less << PHASE4 COMPLETED 2025-05-13 Danish Pain Research Center, A... More >>arhus University Hospital, Aarhus, 8000, Denmark|Department of Neurology, Odense University Hospital, Odense, DK-5000, Denmark Less <<
NCT00142025 Bronchial Asthma PHASE4 COMPLETED 2025-03-02 -
NCT00154362 Conduct Disorder PHASE4 COMPLETED 2025-10-04 -
NCT01051193 Partial Onset Seizures PHASE2|PHASE3 COMPLETED 2019-09-30 NPC Investigative Site, Nagoya... More >>-shi, Aichi, 460-0004, Japan|NPC Investigative Site, Obu-city, Aichi, 474-8710, Japan|NPC Investigative Site, Matsuyama-city, Ehime, 790-8524, Japan|NPC Investigative Site, Fukuoka-city, Fukuoka, 814-0180, Japan|NPC Investigative Site, Kameda-gun, Hokkaido, 041-1111, Japan|NPC Investigative Site, Sapporo-city, Hokkaido, 060-8648, Japan|NPC Investigative Site, Himeji, Hyogo, 670-8540, Japan|NPC Investigative Site, Kobe, Hyogo, 658-0032, Japan|NPC Investigative Site, Yokohama, Kanagawa, 244-0842, Japan|NPC Investigative Site, Koshi-city, Kumamoto, 861-1196, Japan|NPC Investigative Site, Kashiwazaki, Niigata, 945-8585, Japan|NPC Investigative Site, Yufu, Oita, 879-5593, Japan|NPC Investigative Site, Kurashiki, Okayama, 710-8522, Japan|NPC Investigative Site, Okayama-city, Okayama, 700-8558, Japan|NPC Investigative Site, Neyagawa, Osaka, 572-0085, Japan|NPC Investigative Site, Saitama-city, Saitama, 330-8777, Japan|NPC Investigative Site, Moriyama-shi, Shiga, 524-0022, Japan|NPC Investigative Site, Shizuoka-city, Shizuoka, 420-8688, Japan|NPC Investigative Site, Shimotsuke-city, Tochigi, 329-0498, Japan|NPC Investigative Site, Bunkyo-ku, Tokyo, 113-8431, Japan|NPC Investigative Site, Gifu, 502-8558, Japan|NPC Investigative Site, Niigata, 950-2085, Japan|NPC Investigative Site, Saitama, 355-0008, Japan|NPC Investigative Site, Yamagata, 990-0876, Japan Less <<
NCT00275912 Epilepsy, Partial Seizures PHASE4 COMPLETED 2007-09-28 Regional Pediatric Clinical Ho... More >>spital №1 EkaterinburgRegional Pediatric Clinical Hospital №1, Ekaterinburg, Russian Federation|Moscow Scientific Research Institute of Pediatrics and Pediatric Surgery, Moscow, Russian Federation|Russian State Medical University clinically based on Russian Pediatric Clinical Hospital, Moscow, Russian Federation|Scientific-practical centre of children treatment suffering from craniofacial malformation and congenital pathology of nervous system, Moscow, Russian Federation|St. Petersburg State Pediatrics Medical Academy, St Petersburg, Russian Federation Less <<
NCT00145691 Agitation Aggression in Dement... More >>ia Less << PHASE3 COMPLETED 2025-10-06 Sykehuset Innlandet HF, Reinsv... More >>oll, Oppland, 2840, Norway Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.96mL

0.79mL

0.40mL

19.82mL

3.96mL

1.98mL

39.64mL

7.93mL

3.96mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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