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Chemical Structure| 20559-55-1 Chemical Structure| 20559-55-1

Structure of Oxibendazole
CAS No.: 20559-55-1

Chemical Structure| 20559-55-1

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Oxibendazole is a broad-spectrum anthelmintic.

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Product Details of Oxibendazole

CAS No. :20559-55-1
Formula : C12H15N3O3
M.W : 249.27
SMILES Code : O=C(OC)NC1=NC2=CC(OCCC)=CC=C2N1
MDL No. :MFCD00133728
InChI Key :RAOCRURYZCVHMG-UHFFFAOYSA-N
Pubchem ID :4622

Safety of Oxibendazole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Vero cells 50 µM 24 hours Evaluation of Oxibendazole's inhibitory effect on Chikungunya virus replication, showing an inhibition rate of 66.4%. ACS Omega. 2024 Jun 13;9(25):27632-27642
Colorectal cancer cell line SW480 0.96 µM 72 hours Evaluate the antiproliferative effect of Oxibendazole on colorectal cancer cell line SW480, IC50 value was 0.96 µM Pharmaceuticals (Basel). 2021 Apr 17;14(4):372
Colorectal cancer cell line HT-29 0.01 µM 72 hours Evaluate the antiproliferative effect of Oxibendazole on colorectal cancer cell line HT-29, IC50 value was 0.01 µM Pharmaceuticals (Basel). 2021 Apr 17;14(4):372
Paraganglioma cell line PTJ86i 3.29 µM 72 hours Evaluate the antiproliferative effect of Oxibendazole on paraganglioma cell line PTJ86i, IC50 value was 3.29 µM Pharmaceuticals (Basel). 2021 Apr 17;14(4):372
Paraganglioma cell line PTJ64i 1.79 µM 72 hours Evaluate the antiproliferative effect of Oxibendazole on paraganglioma cell line PTJ64i, IC50 value was 1.79 µM Pharmaceuticals (Basel). 2021 Apr 17;14(4):372
Pancreatic cancer cell line BxPC-3 1.07 µM 72 hours Evaluate the antiproliferative effect of Oxibendazole on pancreatic cancer cell line BxPC-3, IC50 value was 1.07 µM Pharmaceuticals (Basel). 2021 Apr 17;14(4):372
Pancreatic cancer cell line AsPC-1 1.45 µM 72 hours Evaluate the antiproliferative effect of Oxibendazole on pancreatic cancer cell line AsPC-1, IC50 value was 1.45 µM Pharmaceuticals (Basel). 2021 Apr 17;14(4):372

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Horse Cyathostomin infection model Oral 10 mg/kg Every 40 weeks or when ten horses exceeded 100 EPG Evaluate the efficacy of Oxibendazole against cyathostomins, showing efficacies of 46.7% and 40.1% for the first and last treatments, respectively. Int J Parasitol Drugs Drug Resist. 2020 Apr;12:28-34
Horse Yearlings Oral 10 mg/kg Single dose Evaluate the efficacy of Oxibendazole in combination with other drugs against parasites in yearlings, showing a 100% fecal egg count reduction Int J Parasitol Drugs Drug Resist. 2020 Dec;14:99-104
Horse Shetland ponies Oral 10 mg/kg Every two weeks until ten ponies exceeded 100 EPG or 40 weeks post treatment To evaluate the efficacy of pyrantel pamoate in combination with oxibendazole against double-drug resistant cyathostomins. Results showed that the first combination treatment had an efficacy of 76%, but three subsequent combination treatments resulted in significantly lower efficacies of around 40%. Int J Parasitol Drugs Drug Resist. 2020 Apr;12:28-34

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.06mL

4.01mL

2.01mL

40.12mL

8.02mL

4.01mL

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