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Chemical Structure| 245765-41-7 Chemical Structure| 245765-41-7

Structure of Ozenoxacin
CAS No.: 245765-41-7

Chemical Structure| 245765-41-7

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Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

Synonyms: T-3912

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Product Citations

Product Citations

Hu, Xiaolan ; Wu, Jian-Lin ; He, Quan ; Xiong, Zhi-Qi ; Li, Na ;

Abstract: Targeted covalent inhibitors, primarily targeting residues, have attracted great attention as potential drug candidates due to good potency and prolonged duration of action. However, their discovery is challenging. In this research, a database-assisted liquid chromatography-tandem mass spectrometry (LC-MS/MS) strategy was developed to quickly discover potential cysteine-targeting compounds. First, compounds with potential reactive groups were selected and incubated with N-acetyl-cysteine in microsomes. And the precursor ions of possible cysteine-adducts were predicted based on covalent binding mechanisms to establish in-house database. Second, substrate-independent product ions produced from N-acetyl-cysteine moiety were selected. Third, multiple reaction monitoring scan was conducted to achieve sensitive screening for cysteine-targeting compounds. This strategy showed broad applicability, and covalent compounds with diverse structures were screened out, offering structural resources for covalent inhibitors development. Moreover, the screened compounds, norketamine and hydroxynorketamine, could modify synaptic transmission-related proteins in vivo, indicating their potential as covalent inhibitors. This experimental-based screening strategy provides a quick and reliable guidance for the design and discovery of covalent inhibitors.

Keywords: Cysteine-targeting inhibitors screening ; Drug Repurposing ; Metabolites ; LC-MS/MS ; Protein Targets

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Product Details of Ozenoxacin

CAS No. :245765-41-7
Formula : C21H21N3O3
M.W : 363.41
SMILES Code : O=C(C1=CN(C2CC2)C3=C(C=CC(C4=CC(C)=C(NC)N=C4)=C3C)C1=O)O
Synonyms :
T-3912
MDL No. :MFCD18633255
InChI Key :XPIJWUTXQAGSLK-UHFFFAOYSA-N
Pubchem ID :9863827

Safety of Ozenoxacin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.28mL

13.76mL

2.75mL

1.38mL

27.52mL

5.50mL

2.75mL

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