Structure of PAC
CAS No.: 2158322-33-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
PAC1 (Compound PAC1) is a PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation.
Synonyms: PROTAC ERα Degrader-5
4.5
*For Research Use Only !
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 2158322-33-7 |
Formula : | C94H107N13O16 |
M.W : | 1674.93 |
SMILES Code : | O=C1C=CC(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC3=CC=C(/C(C4=CC=C(OCCN(C(COCCOCCNC(C5=CC=C(C(N(C6=CC(C#N)=CC=C6N7CC8=C(OC)C=CC9=CC=CC=C98)[C@@H](C)[C@H](NC([C@@H](NC)C)=O)C7=O)=O)C=C5)=O)=O)C)C=C4)=C(CC)\C%10=CC=CC=C%10)C=C3)C=C2)=O)=O)=O)=O |
Synonyms : |
PROTAC ERα Degrader-5
|
MDL No. : | MFCD31657411 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03458351 | Platelet Dysfunction | Not Applicable | Recruiting | June 15, 2019 | Korea, Republic of ... More >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 03080 Contact: Yunseok Jeon 82 2 2072 3108 jeonyunseok@gmail.com Less << |
NCT00075686 | Pancreatic Cancer | Phase 3 | Completed | - | - |
NCT03441412 | Healthy Volunteers | Phase 1 | Completed | - | Sweden ... More >> gothia Forum CTC Gothenburg, Sweden, 41345 Less << |
NCT01238250 | - | Recruiting | July 2018 | United States, Pennsylvania ... More >> Geisinger Health System Recruiting Danville, Pennsylvania, United States, 17822 Contact: Cora Taylor, PhD 570-522-9430 Less << | |
NCT02940327 | - | Recruiting | June 2018 | United Kingdom ... More >> University Hospitals of Leicester NHS Trust Recruiting Leicester, United Kingdom, LE3 9QP Contact: Tracy Kumar, BSc 116 2583039 tk98@leicester.ac.uk Contact: Nikol Sullo, Research Associate ns331@le.ac.uk Less << | |
NCT03316534 | HIV-infected Patients | Phase 2 | Completed | - | - |
NCT02662075 | Smoking | Not Applicable | Withdrawn | - | United States, New York ... More >> New York University School of Medicine New York, New York, United States, 10016 Less << |
NCT03002805 | Sarcoma | Phase 1 | Recruiting | September 2020 | United States, California ... More >> Sarcoma Oncology Research Center Recruiting Santa Monica, California, United States, 90403 Contact: Victoria Chua-Alcala 310-552-9999 vchua@sarcomaoncololgy.com Principal Investigator: Sant P. Chawla, M.D. United States, Florida Mayo Clinic Recruiting Jacksonville, Florida, United States, 32224 Contact: Sherry Cook, RN 904-953-3321 cook.sherry1@mayo.edu Principal Investigator: Steven Attia, D.O. United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Carol Gurski, RN 617-643-1770 egurski@mgh.harvard.edu Principal Investigator: Gregory Cote, M.D., Ph.D. Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Research Nursing 617-632-5204 Principal Investigator: Katherine Thornton, M.D. United States, Pennsylvania University of Pittsburgh Medical Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Melissa Burgess, M.D. 412-692-4724 burgessma@upmc.edu Principal Investigator: Melissa Burgess, M.D. Less << |
NCT03306550 | Angina, Stable | Not Applicable | Not yet recruiting | October 10, 2018 | - |
NCT03460899 | Diabetes Mellitus With Hypogly... More >>cemia Diabetes Mellitus, Type 2 Hypoglycemia Hypoglycemic Episode Less << | Not Applicable | Completed | - | Austria ... More >> Medical University of Graz, Department for Internal Medicine Graz, Austria, 8036 Less << |
NCT00106587 | Coronary Restenosis | Phase 1 Phase 2 | Completed | - | Germany ... More >> Klinik fuer Innere Medizin III, Universitaetsklinikum des Saarlandes Homburg / Saar, Saarland, Germany, 66421 Kardiologie, Campus Mitte, Charite Berlin, Germany, 10117 Kardiologie, Campus Virchow-Klinikum, Charite Berlin, Germany, 13353 Medizinische Universitätsklinik III, Abt. Kardiologie und Angiologie Freiburg, Germany, 79106 I. Medizinische Klinik, Universitaetsklinikum Mannheim, Germany, 68167 Less << |
NCT01865136 | Pregnancy | Phase 4 | Completed | - | Kenya ... More >> Jaramogi Oginga Odinga Teaching and Referral Hospital Kisumu, Kenya Less << |
NCT02100462 | Hypertension | Phase 4 | Unknown | December 2016 | United States, Nebraska ... More >> Creighton University Recruiting Omaha, Nebraska, United States, 68178 Contact: Sandy Byers, RN 402-280-4961 sandrabyers@creighton.edu Sub-Investigator: Tammy L Burns, PharmD, BCPS Principal Investigator: Khalid Bashir, MD Sub-Investigator: Michael White, MD Sub-Investigator: Daniel E Hilleman, PharmD Sub-Investigator: Venkata M Alla, MD Sub-Investigator: Venkata Andukuri, MD Less << |
NCT02532985 | Signs and Symptoms, Digestive | Not Applicable | Completed | - | - |
NCT02530762 | Signs and Symptoms, Digestive | Not Applicable | Completed | - | - |
NCT01454778 | Peripheral Vascular Disease | Not Applicable | Completed | - | United States, South Dakota ... More >> Sanford Vascular Associates Sioux Falls, South Dakota, United States, 57117 Less << |
NCT01454778 | - | Completed | - | - | |
NCT03332355 | Glioblastoma Multiforme ... More >> Anaplastic Astrocytoma Less << | Phase 1 | Recruiting | June 30, 2019 | United States, Illinois ... More >> University of Illinois at Chicago Recruiting Chicago, Illinois, United States, 60612 Contact: Oana C Danciu, M.D. United States, Maryland Johns Hopkins Cancer Center Recruiting Baltimore, Maryland, United States, 21231 Contact: Matthias Holdhoff, M.D. United States, Minnesota Regions Hospital Recruiting Saint Paul, Minnesota, United States, 55101 Contact: Richard Peterson, MD 651-254-3572 Richard.A.Peterson@HealthPartners.Com Principal Investigator: Richard Peterson, MD Sub-Investigator: Daniel Anderson, MD Sub-Investigator: Kurt Demel, MD Sub-Investigator: Randolph Hurley, MD Sub-Investigator: Balkrishna Jahagirdar, MD Sub-Investigator: Pryia Kumar, MD Sub-Investigator: Steven McCormack, MD Sub-Investigator: Gary Shapiro, MD Sub-Investigator: Peter Hurley, MD Sub-Investigator: Stephanie Kroon, PA-C Sub-Investigator: Angela Martizna, RN Sub-Investigator: Joanna Hill Less << |
NCT02355535 | Breast Cancer ... More >> Lymphoma Gastrointestinal Cancers Genitourinary Cancers Gynecologic Cancers Head and Neck Cancers Melanoma Thoracic Cancers Solid Tumors Lymphomas Less << | Phase 1 | Recruiting | June 2019 | United States, Illinois ... More >> University of Illinois at Chicago Recruiting Chicago, Illinois, United States, 60612 Contact: Oana Danciu, MD 312-996-1581 ocdanciu@uic.edu Contact: Alisha Williams, RN (312) 413-2746 alishaw@uic.edu United States, Maryland Johns Hopkins Kimmel Cancer Center Recruiting Baltimore, Maryland, United States, 21231 Contact: Matthias Holdhoff, MD, PhD 410-955-8804 mholdho1@jhmi.edu United States, Minnesota Regions Hospital Recruiting Saint Paul, Minnesota, United States, 55101 Contact: Richard Peterson, MD 651-254-3572 Richard.A.Peterson@HealthPartners.Com Principal Investigator: Richard Peterson, MD Sub-Investigator: Daniel Anderson, MD Sub-Investigator: Kurt Demel, MD Sub-Investigator: Randolph Hurley, MD Sub-Investigator: Balkrishna Jahagirdar, MD Sub-Investigator: Pryia Kumar, MD Sub-Investigator: Steven McCormack, MD Sub-Investigator: Gary Shapiro, MD Sub-Investigator: Peter Hurley, MD Sub-Investigator: Stephanie Kroon, PA-C Sub-Investigator: Angela Martizna, RN Sub-Investigator: Joanna Hill Less << |
NCT00944996 | Major Depression | Not Applicable | Completed | - | Israel ... More >> Tirat Carmel Mental Health Center Tirat Hacarmel, Israel, 30200 Less << |
NCT02355756 | Healthy Volunteers | Early Phase 1 | Completed | - | Belgium ... More >> Centre for Clinical Pharmacology, UZ Leuven Leuven, Vlaams-Brabant, Belgium, 3000 Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
0.60mL 0.12mL 0.06mL |
2.99mL 0.60mL 0.30mL |
5.97mL 1.19mL 0.60mL |
Tags: PAC | PROTAC ERα Degrader-5 | ERR | Endocrinology/Hormones | 2158322-33-7
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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