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Chemical Structure| 2158322-33-7 Chemical Structure| 2158322-33-7

Structure of PAC
CAS No.: 2158322-33-7

Chemical Structure| 2158322-33-7

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PAC1 (Compound PAC1) is a PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation.

Synonyms: PROTAC ERα Degrader-5

4.5 *For Research Use Only !

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Product Details of PAC

CAS No. :2158322-33-7
Formula : C94H107N13O16
M.W : 1674.93
SMILES Code : O=C1C=CC(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC3=CC=C(/C(C4=CC=C(OCCN(C(COCCOCCNC(C5=CC=C(C(N(C6=CC(C#N)=CC=C6N7CC8=C(OC)C=CC9=CC=CC=C98)[C@@H](C)[C@H](NC([C@@H](NC)C)=O)C7=O)=O)C=C5)=O)=O)C)C=C4)=C(CC)\C%10=CC=CC=C%10)C=C3)C=C2)=O)=O)=O)=O
Synonyms :
PROTAC ERα Degrader-5
MDL No. :MFCD31657411

Safety of PAC

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03458351 Platelet Dysfunction Not Applicable Recruiting June 15, 2019 Korea, Republic of ... More >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 03080 Contact: Yunseok Jeon    82 2 2072 3108    jeonyunseok@gmail.com Less <<
NCT00075686 Pancreatic Cancer Phase 3 Completed - -
NCT03441412 Healthy Volunteers Phase 1 Completed - Sweden ... More >> gothia Forum CTC Gothenburg, Sweden, 41345 Less <<
NCT01238250 - Recruiting July 2018 United States, Pennsylvania ... More >> Geisinger Health System Recruiting Danville, Pennsylvania, United States, 17822 Contact: Cora Taylor, PhD    570-522-9430 Less <<
NCT02940327 - Recruiting June 2018 United Kingdom ... More >> University Hospitals of Leicester NHS Trust Recruiting Leicester, United Kingdom, LE3 9QP Contact: Tracy Kumar, BSc    116 2583039    tk98@leicester.ac.uk    Contact: Nikol Sullo, Research Associate       ns331@le.ac.uk Less <<
NCT03316534 HIV-infected Patients Phase 2 Completed - -
NCT02662075 Smoking Not Applicable Withdrawn - United States, New York ... More >> New York University School of Medicine New York, New York, United States, 10016 Less <<
NCT03002805 Sarcoma Phase 1 Recruiting September 2020 United States, California ... More >> Sarcoma Oncology Research Center Recruiting Santa Monica, California, United States, 90403 Contact: Victoria Chua-Alcala    310-552-9999    vchua@sarcomaoncololgy.com    Principal Investigator: Sant P. Chawla, M.D.          United States, Florida Mayo Clinic Recruiting Jacksonville, Florida, United States, 32224 Contact: Sherry Cook, RN    904-953-3321    cook.sherry1@mayo.edu    Principal Investigator: Steven Attia, D.O.          United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Carol Gurski, RN    617-643-1770    egurski@mgh.harvard.edu    Principal Investigator: Gregory Cote, M.D., Ph.D.          Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Research Nursing    617-632-5204       Principal Investigator: Katherine Thornton, M.D.          United States, Pennsylvania University of Pittsburgh Medical Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Melissa Burgess, M.D.    412-692-4724    burgessma@upmc.edu    Principal Investigator: Melissa Burgess, M.D. Less <<
NCT03306550 Angina, Stable Not Applicable Not yet recruiting October 10, 2018 -
NCT03460899 Diabetes Mellitus With Hypogly... More >>cemia Diabetes Mellitus, Type 2 Hypoglycemia Hypoglycemic Episode Less << Not Applicable Completed - Austria ... More >> Medical University of Graz, Department for Internal Medicine Graz, Austria, 8036 Less <<
NCT00106587 Coronary Restenosis Phase 1 Phase 2 Completed - Germany ... More >> Klinik fuer Innere Medizin III, Universitaetsklinikum des Saarlandes Homburg / Saar, Saarland, Germany, 66421 Kardiologie, Campus Mitte, Charite Berlin, Germany, 10117 Kardiologie, Campus Virchow-Klinikum, Charite Berlin, Germany, 13353 Medizinische Universitätsklinik III, Abt. Kardiologie und Angiologie Freiburg, Germany, 79106 I. Medizinische Klinik, Universitaetsklinikum Mannheim, Germany, 68167 Less <<
NCT01865136 Pregnancy Phase 4 Completed - Kenya ... More >> Jaramogi Oginga Odinga Teaching and Referral Hospital Kisumu, Kenya Less <<
NCT02100462 Hypertension Phase 4 Unknown December 2016 United States, Nebraska ... More >> Creighton University Recruiting Omaha, Nebraska, United States, 68178 Contact: Sandy Byers, RN    402-280-4961    sandrabyers@creighton.edu    Sub-Investigator: Tammy L Burns, PharmD, BCPS          Principal Investigator: Khalid Bashir, MD          Sub-Investigator: Michael White, MD          Sub-Investigator: Daniel E Hilleman, PharmD          Sub-Investigator: Venkata M Alla, MD          Sub-Investigator: Venkata Andukuri, MD Less <<
NCT02532985 Signs and Symptoms, Digestive Not Applicable Completed - -
NCT02530762 Signs and Symptoms, Digestive Not Applicable Completed - -
NCT01454778 Peripheral Vascular Disease Not Applicable Completed - United States, South Dakota ... More >> Sanford Vascular Associates Sioux Falls, South Dakota, United States, 57117 Less <<
NCT01454778 - Completed - -
NCT03332355 Glioblastoma Multiforme ... More >> Anaplastic Astrocytoma Less << Phase 1 Recruiting June 30, 2019 United States, Illinois ... More >> University of Illinois at Chicago Recruiting Chicago, Illinois, United States, 60612 Contact: Oana C Danciu, M.D.          United States, Maryland Johns Hopkins Cancer Center Recruiting Baltimore, Maryland, United States, 21231 Contact: Matthias Holdhoff, M.D.          United States, Minnesota Regions Hospital Recruiting Saint Paul, Minnesota, United States, 55101 Contact: Richard Peterson, MD    651-254-3572    Richard.A.Peterson@HealthPartners.Com    Principal Investigator: Richard Peterson, MD          Sub-Investigator: Daniel Anderson, MD          Sub-Investigator: Kurt Demel, MD          Sub-Investigator: Randolph Hurley, MD          Sub-Investigator: Balkrishna Jahagirdar, MD          Sub-Investigator: Pryia Kumar, MD          Sub-Investigator: Steven McCormack, MD          Sub-Investigator: Gary Shapiro, MD          Sub-Investigator: Peter Hurley, MD          Sub-Investigator: Stephanie Kroon, PA-C          Sub-Investigator: Angela Martizna, RN          Sub-Investigator: Joanna Hill Less <<
NCT02355535 Breast Cancer ... More >> Lymphoma Gastrointestinal Cancers Genitourinary Cancers Gynecologic Cancers Head and Neck Cancers Melanoma Thoracic Cancers Solid Tumors Lymphomas Less << Phase 1 Recruiting June 2019 United States, Illinois ... More >> University of Illinois at Chicago Recruiting Chicago, Illinois, United States, 60612 Contact: Oana Danciu, MD    312-996-1581    ocdanciu@uic.edu    Contact: Alisha Williams, RN    (312) 413-2746    alishaw@uic.edu    United States, Maryland Johns Hopkins Kimmel Cancer Center Recruiting Baltimore, Maryland, United States, 21231 Contact: Matthias Holdhoff, MD, PhD    410-955-8804    mholdho1@jhmi.edu    United States, Minnesota Regions Hospital Recruiting Saint Paul, Minnesota, United States, 55101 Contact: Richard Peterson, MD    651-254-3572    Richard.A.Peterson@HealthPartners.Com    Principal Investigator: Richard Peterson, MD          Sub-Investigator: Daniel Anderson, MD          Sub-Investigator: Kurt Demel, MD          Sub-Investigator: Randolph Hurley, MD          Sub-Investigator: Balkrishna Jahagirdar, MD          Sub-Investigator: Pryia Kumar, MD          Sub-Investigator: Steven McCormack, MD          Sub-Investigator: Gary Shapiro, MD          Sub-Investigator: Peter Hurley, MD          Sub-Investigator: Stephanie Kroon, PA-C          Sub-Investigator: Angela Martizna, RN          Sub-Investigator: Joanna Hill Less <<
NCT00944996 Major Depression Not Applicable Completed - Israel ... More >> Tirat Carmel Mental Health Center Tirat Hacarmel, Israel, 30200 Less <<
NCT02355756 Healthy Volunteers Early Phase 1 Completed - Belgium ... More >> Centre for Clinical Pharmacology, UZ Leuven Leuven, Vlaams-Brabant, Belgium, 3000 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.60mL

0.12mL

0.06mL

2.99mL

0.60mL

0.30mL

5.97mL

1.19mL

0.60mL

 

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