Home Cart Sign in  
Chemical Structure| 874302-76-8 Chemical Structure| 874302-76-8
Chemical Structure| 874302-76-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC).

Synonyms: PDEC-NB

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of PDEC-NB

CAS No. :874302-76-8
Formula : C14H12N2O5S2
M.W : 352.39
SMILES Code : O=C(OC1=CC=C([N+]([O-])=O)C=C1)OCCSSC2=NC=CC=C2
Synonyms :
PDEC-NB
MDL No. :MFCD28556879
InChI Key :JHDROZPIXZYTMZ-UHFFFAOYSA-N
Pubchem ID :11638899

Safety of PDEC-NB

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of PDEC-NB

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 874302-76-8 ]

[ 874302-76-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 874302-76-8 ]
  • [ 474645-27-7 ]
  • C47H74N6O9S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With pyridine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 16℃; for 16h;Inert atmosphere; To a solution of compound 1(60mg, 0.17 mmol), MMAE (110 mg, 0.123 mmol), HOBt (4.6 mg, 0.034 mmol) in dry DMF (3.0 mL) was added pyridine (134 mg, 1.7 mmol) at 20°C, and the mixture was allowed to stir at 16°C for 16 h under N2. The mixture was filtered and purified by prep-HPLC (FA conditions), to give compound A (99.7 mg, yield: 64percent) as a whitesolid. LCMS: (10-80, AB, 2 mm), 1.331 mm, MS = 932.5[M+2j; ?H NMR (400 MI-Tz, DMSOd 6) 5 8.46 (d, J= 4.4 Hz, 1 H), 7.80 -7.76 (m, 2 H), 7.56 (s, 1 H), 7.34 -7.18 (m, 7 H), 5.10 (s, 1H), 4.56 -4.51 (m, 2 H), 4.29 -4.16 (m, 3 H), 4.03 (s, 2 H), 3.77 (d, J 11.6Hz, 2 H), 3.37 (d, J= 9.6 Hz, 2 H), 3.28 - 3.23 (m, 8 H), 3.15 (s, 3 H), 2.84 (s, 3 H), 2.40 (s, 2 H), 2.18 (s, 2 H), 2.00(s, 1 H), 1.81 (s, 3 H), 1.62 - 1.56 (m, 2 H), 1.34 (d, J= 6.4 Hz, 1 H), 1.05 - 1.01 (m, 8 H), 0.88 -0.80 (m, 18 H). The molecular weight determined by NMR was 930.50.
  • 2
  • [ 874302-76-8 ]
  • [ 474645-27-7 ]
  • C47H74N6O9S2 [ No CAS ]
 

Historical Records

Categories