Home Cart Sign in  
Chemical Structure| 5534-95-2 Chemical Structure| 5534-95-2

Structure of Pentagastrin
CAS No.: 5534-95-2

Chemical Structure| 5534-95-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Pentagastrin (ICI-50123) is a selective agonist of Cholecystokinin B (CCKB) receptor with an IC50 of 11 nM. Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally, which can cause the secretion and synthesis of salivary proteins.

Synonyms: ICI-50123; AY 6608; Petogasrin

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Pentagastrin

CAS No. :5534-95-2
Formula : C37H49N7O9S
M.W : 767.89
SMILES Code : O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCNC(OC(C)(C)C)=O)=O)CC2=CNC3=C2C=CC=C3
Synonyms :
ICI-50123; AY 6608; Petogasrin
MDL No. :MFCD00076515

Safety of Pentagastrin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Pentagastrin

GPCR

Isoform Comparison

Biological Activity

Description
Pentagastrin (ICI-50123) is identified as a potent, selective antagonist of the Cholecystokinin B (CCKB) receptor, with IC50 values of 11 nM for CCKB and 1100 nM for CCKA receptors. It plays a significant role in enhancing gastric mucosal defense mechanisms against acid and provides protection to the gastric mucosa from experimental damage[1].[2].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01699113 Hypergastrinaemia Phase 1 Completed - United Kingdom ... More >> Hammersmith Medicines Research London, United Kingdom Less <<
NCT00625495 Gastroesophageal Reflux Diseas... More >>e Less << Phase 4 Completed - -
NCT00001229 - Completed - United States, Maryland ... More >> National Heart, Lung and Blood Institute (NHLBI) Bethesda, Maryland, United States, 20892 Less <<
NCT00175045 Esophagitis R... More >>eflux Less << Phase 2 Completed - -
NCT01447849 Constipation Phase 2 Phase 3 Completed - United States, Texas ... More >> Texas Tech University Health Sciences Center El Paso, Texas, United States, 79905 Less <<
NCT01447849 - Completed - -
NCT01601405 Hypergastrinaemia Phase 1 Completed - United Kingdom ... More >> Hammersmith Medicines Research London, United Kingdom Less <<
NCT01601418 Hypergastrinaemia Phase 1 Completed - United Kingdom ... More >> Hammersmith Medicines Research London, United Kingdom Less <<
NCT00635414 GERD Phase 4 Completed - -
NCT00626262 Gastroesophageal Reflux Diseas... More >>e Less << Phase 4 Completed - -
NCT00629564 GERD Phase 4 Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.30mL

0.26mL

0.13mL

6.51mL

1.30mL

0.65mL

13.02mL

2.60mL

1.30mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories