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Chemical Structure| 183945-55-3 Chemical Structure| 183945-55-3

Structure of PfDHODH-IN-1
CAS No.: 183945-55-3

Chemical Structure| 183945-55-3

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PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide that inhibits dihydroorotate dehydrogenase (PfDHODH) in the malaria parasite, demonstrating anti-malarial activity and serving as an important tool for malaria infection research.

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Product Details of PfDHODH-IN-1

CAS No. :183945-55-3
Formula : C14H11F3N2O2
M.W : 296.24
SMILES Code : O=C(/C(C#N)=C(O)/C1CC1)NC2=CC=C(C=C2)C(F)(F)F
MDL No. :N/A
InChI Key :IKNOIAXAHSRIGK-QXMHVHEDSA-N
Pubchem ID :54684419

Safety of PfDHODH-IN-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Related Pathways of PfDHODH-IN-1

DNA

Isoform Comparison

Biological Activity

Description
hDHODH-IN-1, an analog of Leflunomide’s active metabolite, inhibits Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) and exhibits antimalarial properties [1][2].

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Bio Calculators
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1 mM

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10 mM

3.38mL

0.68mL

0.34mL

16.88mL

3.38mL

1.69mL

33.76mL

6.75mL

3.38mL

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