Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	487-41-2
Formula :	C₂₇H₃₄O₁₁
M.W :	534.55
SMILES Code :	COC1=C(C=CC(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=C1)[C@@H]3[C@]4([H])[C@@](CO3)([H])[C@H](C5=CC=C(OC)C(OC)=C5)OC4
Synonyms :	Forsythin
MDL No. :	MFCD00467090
InChI Key :	KFFCKOBAHMGTMW-LGQRSHAYSA-N
Pubchem ID :	101712

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

EA.hy926 cells	20 µM	1 hour	Phillyrin effectively protects against glycocalyx HS degradation in LPS-stimulated EA.hy926 cells, possibly associated with suppressing the production of reactive oxygen species and decreasing expression levels of cathepsin L and heparanase.	Inflammation. 2020 Apr;43(2):540-551
Primary brain microvascular endothelial cells (BMECs)	40 μg/mL	12 hours	Evaluate the effect of Phillyrin on BMEC viability and tube formation ability. Results showed that Phillyrin enhanced BMEC viability and tube formation ability	Front Pharmacol. 2021 Oct 20;12:719823
Madin-Darby Canine Kidney (MDCK) cells	100, 50, 25 µM	12 hourspi and 24 hourspi	Phillyrin suppressed influenza viral replication (Matrixprotein and nucleoprotein mRNA level) and reduced influenza virus-induced cytopathic effect (CPE).	Virol J. 2023 Nov 13;20(1):262
HEp-2 cells	0, 1, 10, 50, 100 µM	12, 24, 48 hours	To evaluate the effect of PHN on the proliferation and apoptosis of HEp-2 cells. Results showed that PHN alone had little effect on HEp-2 cell proliferation and apoptosis.	Biosci Rep. 2019 Jun 20;39(6):BSR20190459
Primary cortical neurons	20, 40, 80 µM	2 hours	Phillyrin significantly increased the viability of H2O2-injured neurons, decreased LDH release, downregulated the Bax/Bcl-2 ratio, and reduced procaspase-3, p-Akt-1, and p-mTOR levels.	Bioengineered. 2022 Mar;13(3):7940-7950
AML-12 cells	200 μg/ml	24 hours	To investigate the effect of Phillyrin on ethanol-induced autophagic flux in AML-12 cells. Results showed that Phillyrin promoted autophagic flux by targeting PDPK1 and inhibiting its Ser241 phosphorylation, thereby reducing intracellular lipid droplet accumulation.	Cell Death Dis. 2022 Nov 23;13(11):991
293T cells	100 μg/ml	24 hours	To evaluate the effect of Phillyrin on influenza viral RNA polymerase activity, results showed that Phillyrin significantly inhibited viral RNA polymerase activity.	Influenza Other Respir Viruses. 2023 Mar 1;17(3):e13112
PC12 cells	1, 5, 10 μg/ml	24 hours	To evaluate the protective effect of Phillyrin on H2O2-induced damage in PC12 cells. Results showed that Phillyrin pretreatment significantly increased cell viability, reduced LDH leakage, and inhibited H2O2-induced oxidative stress and apoptosis.	Cell Mol Neurobiol. 2014 Nov;34(8):1165-73
MLE-12 cells	10, 20, 40 µM	24 hours	To evaluate the protective effect of Phillyrin on LPS-induced pyroptosis in MLE-12 cells. Results showed that PHI pretreatment significantly ameliorated LPS-induced morphological changes, reduced LDH release and PI-positive cell ratio, and inhibited the activation of the NLRP3/caspase-1/GSDMD-dependent pyroptosis signaling pathway.	Acta Biochim Biophys Sin (Shanghai). 2024 Oct 10;57(3):447-462
RAW264.7 cells	0.0015 mg/mL	24 hours	Evaluate the anti-inflammatory activity of Phillyrin, results showed that Phillyrin significantly inhibited LPS-induced inflammatory cytokine release.	Ultrason Sonochem. 2024 Aug;108:106944
Adipose tissue explants	200 µM	24 hours	To investigate the effect of Phillyrin on IL-6 production in LPS-stimulated adipose tissue explants. Results showed that Phillyrin significantly reduced LPS-induced IL-6 mRNA levels and secretion.	Front Nutr. 2022 Oct 5;9:956218
Primary microglia	10-40 μg/mL	4 or 24 hours	Evaluate the effect of Phillyrin on the viability and morphology of microglia. Results showed that all concentrations of Phillyrin had no adverse effects on microglial cell viability and reduced LPS-induced amoeboid cell numbers	Front Pharmacol. 2021 Oct 20;12:719823
Madin–Darby Canine Kidney (MDCK) cells	100 μg/ml	48 hours	To evaluate the effect of Phillyrin on influenza virus-induced cytopathic effect (CPE), results showed that Phillyrin significantly reduced virus-induced CPE.	Influenza Other Respir Viruses. 2023 Mar 1;17(3):e13112
Bone marrow-derived macrophages (BMMs)	0, 2.5, 5, 10, 20 µM	5 days	To evaluate the effect of Phillyrin on RANKL-induced osteoclast differentiation. Results showed that Phillyrin significantly inhibited RANKL-induced osteoclast formation and bone resorption activity.	Front Pharmacol. 2019 Oct 17;10:1188
Adipose tissue explants	1-200 µM	6 hours	To investigate the effect of Phillyrin on IL-6-induced basal lipolysis. Results showed that Phillyrin significantly inhibited IL-6-induced basal lipolysis, with 200 μM completely blocking the effect of IL-6.	Front Nutr. 2022 Oct 5;9:956218

C57BL/10ScNJ mice	Traumatic brain injury (TBI) model	Intraperitoneal injection	10 mg/kg	1 hour before surgery and daily thereafter for 7 days	Evaluate the effect of Phillyrin on BBB damage in TBI mice. Results showed that Phillyrin reduced TBI-induced BBB damage, decreased Evans blue extravasation, and improved cerebral microvascular integrity	Front Pharmacol. 2021 Oct 20;12:719823
BALB/c mice	H1N1 influenza (PR8)-induced pneumonia model	Intraperitoneal injection	15 mg/kg	Once daily for 6 days	Phillyrin significantly improved the weight loss caused by viral infection, ameliorated pulmonary inflammation, and inhibited the accumulation of multiple cytokines and chemokines in bronchoalveolar lavage fluid.	Virol J. 2023 Nov 13;20(1):262
C57BL/6 mice	Cecal ligation and puncture (CLP)-induced septic acute lung injury model	Intragastric administration	15, 30, 60 mg/kg	Once daily for seven consecutive days	To evaluate the protective effect of Phillyrin on sepsis-induced acute lung injury. Results showed that PHI pretreatment significantly reduced pulmonary edema, systemic/pulmonary inflammation, and pulmonary histological damage, and inhibited the activation of the NLRP3/caspase-1/GSDMD-dependent pyroptosis signaling pathway.	Acta Biochim Biophys Sin (Shanghai). 2024 Oct 10;57(3):447-462
C57BL/6 mice	Alcoholic steatohepatitis (ASH) model	Gavage	15, 45 mg/kg	Once daily for 10 days	To evaluate the protective effect of Phillyrin in the ASH mouse model. Results demonstrated that Phillyrin significantly reduced hepatic lipid droplet accumulation, lowered serum ALT and AST levels, and alleviated liver injury by promoting autophagic flux.	Cell Death Dis. 2022 Nov 23;13(11):991
C57BL/6 mice	DSS-induced colitis model	Oral	12.5, 25.0, and 50.0 mg/kg	Daily administration for 15 days	Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway. The results showed that Phillyrin significantly reduced weight loss, colon shortening, increased secretion of inflammatory factors, increased intestinal permeability, and enhanced disease activity index in mice with ulcerative colitis (UC). Molecular studies determined that Phillyrin mitigates the nuclear translocation of nuclear factor kappa B, thereby downregulating myosin light-chain kinase-driven myosin light-chain phosphorylation, preserving the integrity of the intestinal barrier. 16S rRNA sequencing outcomes suggest that Phillyrin (50 mg/kg) increased the relative abundance of certain probiotic strains, including Lactobacillaceae and Lachnospiraceae. Additionally, Phillyrin supplementation elevated the short-chain fatty acid contents within the intestinal contents of mice with UC.	Microbiol Spectr. 2025 Feb 4;13(2):e0200624
C57BL/6J mice	High-fat diet-induced obesity model	Oral gavage	25 and 50 mg/kg	Once daily for 9 weeks	To evaluate the metabolic effects of Phillyrin in high-fat diet-induced obese mice. Results showed that Phillyrin significantly reduced weight gain, improved insulin sensitivity, decreased hepatic lipid accumulation, and attenuated adipose tissue inflammation and IL-6 production.	Front Nutr. 2022 Oct 5;9:956218
Sprague Dawley (SD) rats	MCAO/R model	Gavage	25, 50, 100 mg/kg	Once daily for three days	Phillyrin significantly reduced cerebral infarction volume, neurological score, and brain water content, and inhibited neuron apoptosis.	Bioengineered. 2022 Mar;13(3):7940-7950
C57BL/6 male mice	LPS-induced acute kidney injury model	Intragastric administration	40 mg/kg/day	Once daily for 7 days	Phillyrin alleviates LPS-induced acute kidney injury by protecting against glycocalyx HS damage and inhibiting inflammatory responses.	Inflammation. 2020 Apr;43(2):540-551
C57BL/6 mice	LPS-induced calvarial osteolysis model	Intraperitoneal injection	5 and 10 mg/kg	Every other day for 7 days	To evaluate the protective effect of Phillyrin on LPS-induced osteolysis. Results showed that Phillyrin significantly inhibited LPS-induced osteolysis, reducing the number of TRAP+ osteoclasts and bone erosion area.	Front Pharmacol. 2019 Oct 17;10:1188

{[proInfo.proName]}

CAS No.: 487-41-2

{[proInfo.proName]}

CAS No.: 487-41-2

Alternative Products

Product Details of Phillyrin

Safety of Phillyrin

Related Pathways of Phillyrin

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed