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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 477-47-4 Chemical Structure| 477-47-4

Structure of Picropodophyllin
CAS No.: 477-47-4

Chemical Structure| 477-47-4

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Picropodophyllin (AXL1717) is a selective inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) with an IC50 of 1 nM.

Synonyms: Picropodophyllotoxin; AXL1717; NSC 36407

4.5 *For Research Use Only !

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Product Details of Picropodophyllin

CAS No. :477-47-4
Formula : C22H22O8
M.W : 414.41
SMILES Code : O=C1OC[C@]2([H])[C@@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(OC)C(OC)=C5)[C@@]21[H]
Synonyms :
Picropodophyllotoxin; AXL1717; NSC 36407
MDL No. :MFCD01742647
InChI Key :YJGVMLPVUAXIQN-HAEOHBJNSA-N
Pubchem ID :72435

Safety of Picropodophyllin

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H312-H315-H319-H335
Precautionary Statements:P261-P280-P301+P310-P305+P351+P338
Class:6.1
UN#:3462
Packing Group:

Related Pathways of Picropodophyllin

RTK

Isoform Comparison

Biological Activity

Target
  • IGF-1R

    IGF-1R, IC50:1 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01062620 Solid Tumors PHASE1 COMPLETED - Uppsala University Hospital, U... More >>ppsala, SE-75185, Sweden Less <<
NCT01721577 Glioblastoma|Gliosarcoma|Anapl... More >>astic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma|Anaplastic Ependymoma Less << PHASE1|PHASE2 TERMINATED 2025-12-15 Rush University Medical Center... More >>, Chicago, Illinois, 60612, United States Less <<
NCT01466647 Non Small Cell Lung Cancer PHASE1 COMPLETED 2025-09-12 KFUE, Uppsala, Sweden|Universi... More >>ty Hospital, Uppsala, Sweden Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.07mL

2.41mL

1.21mL

24.13mL

4.83mL

2.41mL

 

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