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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 900185-02-6 Chemical Structure| 900185-02-6

Structure of PIK-294
CAS No.: 900185-02-6

Chemical Structure| 900185-02-6

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PIK-294 is a potent and selective p110δ inhibitor with IC50 of 10 nM while 10,000/490/160 nM for p110α/β/γ.

4.5 *For Research Use Only !

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Product Details of PIK-294

CAS No. :900185-02-6
Formula : C28H23N7O2
M.W : 489.53
SMILES Code : O=C1N(C2=CC=CC=C2C)C(CN3N=C(C4=CC=CC(O)=C4)C5=C(N)N=CN=C53)=NC6=C1C(C)=CC=C6
MDL No. :MFCD17019338
InChI Key :WFSLJOPRIJSOJR-UHFFFAOYSA-N
Pubchem ID :24905149

Safety of PIK-294

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P301+P310+P330
Class:6.1
UN#:2811
Packing Group:

Related Pathways of PIK-294

PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • p110γ

    p110γ, IC50:160 nM

  • p110β

    p110β, IC50:490 nM

  • p110δ

    p110δ, IC50:10 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
Neutrophils 10 μM 30 minutes To investigate the effect of PIK-294 on GM-CSF-induced neutrophil migration. Results showed that 10 μM PIK-294 almost completely abolished GM-CSF-induced migration. PMC4320071
Neutrophils 1 μM and 10 μM 30 minutes To investigate the effect of PIK-294 on CXCL8-induced neutrophil migration. Results showed that PIK-294 significantly inhibited both chemokinetic and chemotactic migration induced by CXCL8. PMC4320071

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.21mL

2.04mL

1.02mL

20.43mL

4.09mL

2.04mL

References

 

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