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Chemical Structure| 677338-12-4 Chemical Structure| 677338-12-4

Structure of PIK-90
CAS No.: 677338-12-4

Chemical Structure| 677338-12-4

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PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ (IC50= 350 nM).

Synonyms: PIK-85

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Product Details of PIK-90

CAS No. :677338-12-4
Formula : C18H17N5O3
M.W : 351.36
SMILES Code : O=C(C1=CC=CN=C1)NC2=NC3=C(C=CC(OC)=C3OC)C4=NCCN24
Synonyms :
PIK-85
MDL No. :MFCD12910483
InChI Key :FCKJZIRDZMVDEM-UHFFFAOYSA-N
Pubchem ID :135398491

Safety of PIK-90

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Related Pathways of PIK-90

PI3K-AKT

Isoform Comparison

Biological Activity

Target
  • p110γ

    PI3Kγ, IC50:18 nM

  • p110β

    PI3Kβ, IC50:350 nM

  • p110α

    PI3Kα, IC50:11 nM

  • p110δ

    PI3Kδ, IC50:58 nM

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice GBM43 cells implanted subcutaneously Intraperitoneal injection 40 mg/kg daily for 12 days PIK-90 showed clear single-agent efficacy in reducing tumor size PMC3411950

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.28mL

14.23mL

2.85mL

1.42mL

28.46mL

5.69mL

2.85mL

References

 

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