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Chemical Structure| 5625-37-6 Chemical Structure| 5625-37-6
Chemical Structure| 5625-37-6

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PIPES (1,4-Piperazinediethanesulfonic acid) is a key component of PIPES buffer and is widely used as a reagent in the biochemical field.

Synonyms: 1,4-Piperazinediethanesulfonic acid

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of PIPES

CAS No. :5625-37-6
Formula : C8H18N2O6S2
M.W : 302.37
SMILES Code : O=S(CCN1CCN(CCS(=O)(O)=O)CC1)(O)=O
Synonyms :
1,4-Piperazinediethanesulfonic acid
English Name :2,2'-(Piperazine-1,4-diyl)diethanesulfonic acid
MDL No. :MFCD00006159
InChI Key :IHPYMWDTONKSCO-UHFFFAOYSA-N
Pubchem ID :79723

Safety of PIPES

Application In Synthesis of PIPES

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5625-37-6 ]

[ 5625-37-6 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 5625-37-6 ]
  • [ 107-22-2 ]
  • [ 25127-57-5 ]
YieldReaction ConditionsOperation in experiment
With (batho)2CuII (batho = 2,9-dimethyl-4,7-diphenyl-1,10-phenanthrolinedisulfonate); water at 25℃; for 24h; pH 8;
YieldReaction ConditionsOperation in experiment
Natriumbromaethansulfonat, Piperazin*6H2O;
Examples of the Good's buffer include, but are not limited to, N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), 2-morpholinoethanesulfonic acid (MES), N-(2-acetamide) iminodiacetic acid (ADA), piperazine-N,N'-bis(2-ethanesulfonic acid) (PIPES), N-(2-acetamide)-2-aminoethanesulfonic acid (ACES), 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO), 3-morpholinopropanesulfonic acid (MOPS), N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES), 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES), ...
  • 3
  • [ 100-97-0 ]
  • [ 415974-43-5 ]
  • [ 5625-37-6 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
In ammonia; water aq. NH3; acid and amine added to aq. soln. of AgCH3COO; stirred for 15 min; ppt. dissolved by dropwise addn. of aq. NH3; soln. evapd. for 2 d at room temp.;
  • 4
  • [ CAS Unavailable ]
  • [ CAS Unavailable ]
  • [ 5625-37-6 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide In methanol; water for 1.5h;
  • 5
  • [ 110-85-0 ]
  • [ CAS Unavailable ]
  • [ 5625-37-6 ]
YieldReaction ConditionsOperation in experiment
86.3% With sodium hydroxide In water for 3h; 3; 5; 6 Comparative Example 3: A preparation method of piperazine ethanesulfonic acid derivative includes the following steps: 1) Mix 44.7g (0.52mol) anhydrous piperazine, 184.5g (1mol) sodium 2-chloroethylsulfonate with 300mL of water, stir evenly, warm to boiling, add 30wt% NaOH solution dropwise to control the pH to 9-9.5, reflux reaction for 3h;2) The reaction solution was cooled to room temperature, concentrated hydrochloric acid was added to the reaction solution to adjust the pH to 1-2, a large amount of white solid was precipitated, filtered, dried and titrated, and the content was 86%;3) Add the solid obtained in step 2) to 600 mL of water, add alkali to dissolve it, filter, collect the filtrate, adjust the pH to 1-2 by adding concentrated hydrochloric acid to the mother liquor, precipitate a large amount of white solid, filter, rinse and pump with absolute ethanol Drying and drying to obtain 134g of light yellow viscous solidified body, the content after titration was 97.2%, and the yield was 86.3%.
  • 6
  • [ 2781850-88-0 ]
  • [ 5625-37-6 ]
YieldReaction ConditionsOperation in experiment
Stage #1: C14H30N2O6S2 With Sodium hydrogenocarbonate In tetrahydrofuran at 65℃; for 1h; Stage #2: With glacial acetic acid In ethanol 2.2-2.4 Preparation step S2: Under stirring conditions, the above-mentioned 100g compound 3 was added to a 1L dry reactor, the reaction solvent was tetrahydrofuran, and the M-containing reagent; wherein the M-containing reagent was sodium bicarbonate, and the molar ratio of the compound 3 to the M-containing reagent was 1:1, The reaction temperature was 65° C., the reaction pressure was 0.2 MPa (gauge pressure), and the reaction time was 1 h. After the reaction is completed, the temperature is lowered to normal temperature, and the solvent is removed by rotary evaporation of the reaction solution under reduced pressure, and concentrated to prepare a crude product of piperazine-N,N'-bis(2-ethanesulfonic acid) disodium salt. Dissolve the piperazine-N,N'-bis(2-ethanesulfonic acid) disodium crude product prepared in step S2 in ethanol, use glacial acetic acid to adjust the pH to 4-5, stir, cool and clean the crystal, filter, and dry to obtain piperazine-N,N'-bis(2-ethanesulfonic acid). Under dry conditions, using a dry closed device, the piperazine-N,N'-bis(2-ethanesulfonic acid) obtained in the preparation step S3 is dissolved in the purified solvent ethanol, recrystallized under low temperature conditions, filtered, After drying, the refined compound containing sulfonic acid group was obtained; the yield of piperazine-N,N'-bis(2-ethanesulfonic acid) was 70%, and the product purity was 99.9%.
 

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