Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	72496-41-4
Formula :	C₃₂H₃₇NO₁₂
M.W :	627.64
SMILES Code :	O=C1C2=C(C=CC=C2OC)C(C3=C(O)C4=C([C@@H](O[C@@]5([H])C[C@H](N)[C@H](O[C@@]6([H])OCCCC6)[C@H](C)O5)C[C@@](C(CO)=O)(O)C4)C(O)=C31)=O
Synonyms :	THP; NSC-333054
MDL No. :	MFCD00869742

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H340-H350-H360
Precautionary Statements:	P201-P202-P280-P308+P313-P8624-P405-P501

H9C2 cardiomyocytes	5 μM	22 h	Establish THP-induced cell injury model, THP significantly decreased cell activity	PMC8554014
MDA-MB-468	3 μM	24 h	To study the effect of THP on circZCCHC2 expression in MDA-MB-468 cells, the results showed that THP significantly downregulated circZCCHC2 expression.	PMC10867422
MDA-MB-231	5 μM	24 h	To study the effect of THP on circZCCHC2 expression in MDA-MB-231 cells, the results showed that THP significantly downregulated circZCCHC2 expression.	PMC10867422
MDA-MB-231 cells	20 μg/mL	2 h	To evaluate the cellular uptake and drug release of P60-ICG-THP triggered by acidic pH, the results showed that THP could immediately cross the cell membrane and enter the nucleus at pH 6.5, while ICG was mainly located in the cytoplasm.	PMC7667678
HCM cells	5 μM	24 h	To evaluate the effect of Pirarubicin on the survival rate of HCM cells, the results showed that 5 μM Pirarubicin treatment for 24 h significantly reduced cell viability.	PMC10982373
H9c2 cells	5 μM	24 h	To evaluate the effect of Pirarubicin on the survival rate of H9c2 cells, the results showed that 5 μM Pirarubicin treatment for 24 h significantly reduced cell viability.	PMC10982373

BALB/c nude mice	Xenograft tumor model	Tail vein injection	5 mg/kg	Once a week for four weeks	To study the effect of circZCCHC2 on THP sensitivity in vivo, the results showed that circZCCHC2 overexpression partially rescued the tumor inhibitory effect of THP.	PMC10867422
Nude mice	MDA-MB-231 tumor model	Caudal vein injection	20 mg/kg	Once daily for 21 days	To evaluate the antitumor effect of P60-ICG-THP in vivo, the results showed that P60-ICG-THP significantly inhibited tumor growth through the combination of chemotherapy, photothermal therapy, and starvation therapy.	PMC7667678
Wistar rats	Pirarubicin-induced cardiotoxicity model	Caudal vein injection	3 mg/kg	Once a week for 6 weeks	To evaluate the effect of Pirarubicin on cardiotoxicity in rats, the results showed that Pirarubicin significantly reduced cardiac function and increased serum levels of myocardial enzymes.	PMC10982373
SD rats	THP-induced cardiotoxicity model	Caudal vein injection	3 mg/kg	Once a week for 8 weeks	To study THP-induced cardiotoxicity and observe the protective effect of SchB. THP caused decreased and food intake, abnormal ECG and echocardiogram, myocardial tissue damage, and increased cardiomyocyte apoptosis, which were effectively alleviated by SchB	PMC8554014

{[proInfo.proName]}

CAS No.: 72496-41-4

{[proInfo.proName]}

CAS No.: 72496-41-4

Alternative Products

Product Details of Pirarubicin

Safety of Pirarubicin

Related Pathways of Pirarubicin

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

NCT03277716	Hepatocellular Carcinoma Non-r... More >>esectable Transarterial Chemoembolization Microwave Ablation Less <<	Not Applicable	Recruiting	December 30, 2021	China, Beijing ... More >> Cancer Institute &Hospital, Chinese Academy of Medical Sciences Not yet recruiting Beijing, Beijing, China, 100021 Contact: Xiao Li, M.D China, Fujian The First Affiliated Hospital of Fujian Medical University Recruiting Fuzhou, Fujian, China, 350005 Contact: Zhenyu Lin, M.D. The tumor hospital of Fujian Province Not yet recruiting Fuzhou, Fujian, China, 350014 Contact: Hailan Lin, M.D China, Guangdong the First Affiliated Hospital of SunYat-senUniversity Not yet recruiting Guangzhou, Guangdong, China, 510080 Contact: Jiaping Li, M.D Shenzhen People's Hospital Recruiting Shenzhen, Guangdong, China, 518020 Contact: Yanfang Zhang, M.D. Peking University Hospital of Shenzhen Recruiting Shenzhen, Guangdong, China, 518036 Contact: Junhui Chen, M.D. China, Shandong The Second Affiliated Hospital of Shandong University Recruiting Jinan, Shandong, China, 250000 Contact: Yuliang Li, M.D Shandong Province Hospital Recruiting Jinan, Shandong, China, 250014 Contact: Xin Ye, M.D the Affiliated Hospital of Medical College Qingdao University Recruiting Qingdao, Shandong, China, 26555 Contact: Zixiang Li, M.D China, Zhejiang The First Affiliated Hospital of Zhejiang University Not yet recruiting Hangzhou, Zhejiang, China, 310003 Contact: Junhui Sun, M.D. Less <<
NCT00131053	Lymphoblastic Leukemia, Acute	Phase 2	Unknown	September 2011	Japan ... More >> Department of Hematology, Nagoya University Graduate School of Medicine Recruiting Nagoya, Japan, 466-8550 Contact: Fumihiko Hayakawa, MD bun-hy@med.nagoya-u.ac.jp Principal Investigator: Fumihiko Hayakawa, MD Less <<
NCT02760953	Urinary Bladder Neoplasms	Not Applicable	Not yet recruiting	December 31, 2018	-
NCT02435953	Hepatocellular Carcinoma ... More >> Chemoembolization, Therapeutic Ablation Techniques, RFA Less <<	Phase 4	Recruiting	-	China, Guangdong ... More >> Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-sen University Cancer Center, Recruiting Guangzhou, Guangdong, China, 500060 Contact: Ming Zhao, doctor +86 020 87343272 zhaoming@sysucc.org.cn Contact: Tao Pan, doctor +86 020 87343271 pantao0909@hotmail.com Less <<
NCT03503864	Neuroblastoma	Phase 2	Recruiting	December 30, 2029	China, Guangdong ... More >> Sun Yat-sen Memorial Hospital, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Yang Li, Professor +8602081332456 drliyang@126.com Less <<
NCT01430013	T Cell Lymphoma	Phase 2	Unknown	December 2015	China, Tianjin ... More >> Tianjin Medical University Cancer Institute and Hospital Tianjin, Tianjin, China, 300060 Less <<
NCT02956772	Primary Hepatocellular Carcino... More >>ma Less <<	Phase 2	Not yet recruiting	November 2020	China, Guizhou ... More >> Guizhou Cancer Hospital Not yet recruiting Guiyang, Guizhou, China Contact: Shi Zhou, Dr. 258600801@qq.com Guizhou Province Tumor Hospital Not yet recruiting Guiyang, Guizhou, China Contact: Junxiang Li, Dr. 258600801@qq.com China, Hunan Hunan Provincial People's Hospital Not yet recruiting Changsha, Hunan, China, 410001 Contact: Hua Xiang, Dr. +86-13667367061 Contact: Lin Long, Dr. +86-13507476175 doclongll@163.com Hunan Cancer Hospital Not yet recruiting Changsha, Hunan, China Contact: Guowen LI, Dr. liguowen@hnszlyy.com Xiangya Hospital Central South University Not yet recruiting Changsha, Hunan, China Contact: Chunhui Zhou, Dr. zhouchunhui2016@163.com The First Affiliated Hospital of University of South China Not yet recruiting Hengyang, Hunan, China Contact: Youhua Wu, Dr. 330270372@qq.com China, Jiangsu Jiangsu Province Hospital Not yet recruiting Nanjing, Jiangsu, China Contact: Zhen-Qiang Yang, Dr. ntdoctoryang@hotmail.com China, Xinjiang Xinjiang Medical University Cancer Hospital Not yet recruiting Urumqi, Xinjiang, China Contact: Shufa Yang, Dr. yangshufa2013@sina.com China, Yunnan The Tumor Hospital of Yunnan Province Not yet recruiting Kunming, Yunnan, China Contact: Ming Huang, Dr. huangming4328@sina.com Less <<
NCT02396043	Lymphoma, Lymphoblastic	Phase 2	Recruiting	March 2020	China, Guangdong ... More >> Sun Yat-sen University Cancer Center Recruiting GuangZhou, Guangdong, China, 510060 Contact: Zhongjun Xia, MD. 0086-02087342438 zhongjunxia_64@sina.com Less <<
NCT03121833	Soft Tissue Sarcoma, Adult, St... More >>age IIB Less <<	Phase 2	Recruiting	May 1, 2019	China, Tianjin ... More >> Tianjin Medical University Cancer Hospital & Institute Recruiting Tianjin, Tianjin, China, 300060 Contact: Jilong Yang, M.D., Ph.D. +8618622221626 yangjilong@tjmuch.com Less <<
NCT02301091	Hepatocellular Carcinoma	Phase 3	Recruiting	October 2019	China, Guangdong ... More >> Minimally Invasive Interventional Division, Medical Imaging Center, Sun Yat-sen University Cancer Center, Recruiting Guangzhou, Guangdong, China, 500060 Contact: Ming Zhao, doctor +86 020 87343272 zhaoming@sysucc.org.cn Less <<
NCT02838225	Breast Cancer	Phase 2	Completed	-	-
NCT02525952	Hepatocellular Carcinoma	Not Applicable	Unknown	December 2017	China, Shanghai ... More >> Eastern hepatobilliary surgery hospital Recruiting Shanghai, Shanghai, China, 200438 Contact: Yong Xia, Doctor 86-021-81875495 Eastern hepatobilliary surgery hospital Recruiting Shanghai, Shanghai, China, 200438 Contact: Shen Feng, MD 0086-021-25070805 shenfengdfgd@yahoo.com.cn Contact: Wu Dong, MD 0086-021-25070765 wuyuz@yahoo.com.cn Principal Investigator: Shen Feng, MD Less <<
NCT02724358	Hepatocellular Carcinoma ... More >> TACE Notch1 Rg3 Less <<	Not Applicable	Completed	-	China, Shanghai ... More >> Eastern hepatobilliary surgery hospital Shanghai, Shanghai, China, 200438 Less <<
NCT02953184	Antineoplastic Combined Chemot... More >>herapy Protocols Less <<	Phase 2	Recruiting	November 2020	China, Jilin ... More >> First Hospital of Jilin University Recruiting Changchun, Jilin, China, 130021 Contact: Aiping Shi, Doctor 0086-13364308696 13364308696@163.com Contact: Zhimin Fan, Doctor 0086-13756661286 fanzhimn@163.com Sub-Investigator: Di Wu, Doctor Sub-Investigator: Hongyao Jia, Master Sub-Investigator: Xin Guan, Master Principal Investigator: Zhimin Fan, Doctor Principal Investigator: Haibo Wang, Doctor Sub-Investigator: Gang Nie, Doctor Less <<
NCT02585479	Hepatocellular Carcinoma	Phase 2 Phase 3	Unknown	October 2017	-
NCT02584556	Hepatocellular Carcinoma	Phase 2 Phase 3	Unknown	October 2017	-
NCT02755311	Hepatocellular Carcinoma	Phase 3	Unknown	June 2016	China, Guangdong ... More >> The First Affiliated Hospital of Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Zhenwei Peng, MD pengzhenwei2005@163.com Less <<
NCT02547350	Upper Tract Urothelial Carcino... More >>ma Bladder Recurrence Less <<	Phase 2	Not yet recruiting	-	-
NCT02740426	Upper Tract Urothelial Carcino... More >>ma\|Bladder Recurrence Less <<	PHASE2	UNKNOWN	2025-05-22	Peking University First Hospit... More >>al, Beijing, Beijing, 100034, China Less <<
NCT02613026	Breast Neoplasms	Phase 3	Completed	-	China, Hebei ... More >> The fourth hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050010 China, Heilongjiang Harbin Medical University Cancer Hospital Harbin, Heilongjiang, China, 150081 China, Hunan Hunan Provincial People's Hospital Changsha, Hunan, China, 410005 Xiangya Hospital, Central South University Changsha, Hunan, China, 410008 China, Jiangsu Jiangsu Cancer Hospital Nanjing, Jiangsu, China, 210000 Less <<
NCT02923557	Bladder Recurrence\|Upper Tract... More >> Urothelial Carcinoma\|Nephroureterectomy Less <<	PHASE2	UNKNOWN	-	Peking University Frist Hospit... More >>al, Beijing, Beijing, 10034, China Less <<
NCT01249690	Multiple Myeloma	Phase 4	Unknown	June 2014	China, Shang Hai ... More >> Shanghai Changzheng Hospital Recruiting Shang Hai, Shang Hai, China, 200003 Contact: Hou houjian_czyy@sina.cn Principal Investigator: Jian Hou Less <<
NCT01746992	ALK-negative Anaplastic Large ... More >>Cell Lymphoma Peripherial T Cell Lymphoma,Not Otherwise Specified Angioimmunoblastic T Cell Lymphoma Enteropathy Associated T Cell Lymphoma Hepatosplenic T Cell Lymphoma Subcutaneous Panniculitis Like T Cell Lymphoma Less <<	Phase 4	Active, not recruiting	December 2018	China, Shanghai ... More >> Ruijin hospital Shanghai, Shanghai, China, 200025 Less <<
NCT02903524	Breast Cancer	Phase 4	Unknown	December 2018	China, Hebei ... More >> Fourth Hospital of Hebei Medical University Recruiting Shi Jiazhuang, Hebei, China, 050019 Contact: Geng Cuizhi, archiater 0311-66696310 gengcuizhi@hotmail.com Less <<
NCT03030157	Intravesical Instillation	Phase 2	Recruiting	-	China, Shanghai ... More >> Renji Hospital Recruiting Shanghai, Shanghai, China, 200127 Contact: jiwei huang, M.D 8613651682825 jiweihuang@outlook.com Contact: jin zhang 86-21-68383776 zhangjin@renji.com Less <<
NCT03342300	Progression-free Survival ... More >> Overall Survival Toxicity Less <<	Phase 2 Phase 3	Recruiting	December 30, 2019	China ... More >> Peking University People's Hospital Recruiting Beijing, China, 100044 Contact: Tingting Ren, Ph.D. +86-13810095026 tumorcenter@163.com Principal Investigator: Wei Guo, M.D. and Ph.D. Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed