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Chemical Structure| 2101700-15-4 Chemical Structure| 2101700-15-4

Structure of Pirtobrutinib
CAS No.: 2101700-15-4

Chemical Structure| 2101700-15-4

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Pirtobrutinib is a highly selective and non-covalent BTK inhibitor, which may be regarded as a third generation BTK inhibitor. It potently inhibited the cellular activity (measured by Y223 autophosphorylation) of BTK C481S, T and R mutations and displayed strong equilibrium binding to WT BTK and several BTK C481 substitution mutations. It may overcome acquired resistance to covalent BTK inhibitors in patients without significant off-target toxicity.

Synonyms: LOXO-305; LY 3527727; RXC-005

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Product Details of Pirtobrutinib

CAS No. :2101700-15-4
Formula : C22H21F4N5O3
M.W : 479.43
SMILES Code : C(N)(=O)C=1C(=NN([C@H](C(F)(F)F)C)C1N)C2=CC=C(CNC(=O)C3=C(OC)C=CC(F)=C3)C=C2
Synonyms :
LOXO-305; LY 3527727; RXC-005
MDL No. :N/A
InChI Key :FWZAWAUZXYCBKZ-NSHDSACASA-N
Pubchem ID :129269915

Safety of Pirtobrutinib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Related Pathways of Pirtobrutinib

RTK

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06390956 Marginal Zone Lymphoma PHASE2 RECRUITING 1932-12-01 Huntsman Cancer Institute at U... More >>niversity of Utah, Salt Lake City, Utah, 84112, United States Less <<
NCT05172700 Leukemia, Lymphocytic, Chronic... More >>, B-Cell|Lymphoma, Lymphocytic, Small|Lymphoma, Mantle-Cell|Waldenstrom Macroglobulinemia|Ritcher's Transformation, Syndrome Less << APPROVED_FOR_MARKETING - -
NCT06190678 Healthy|Renal Insufficiency PHASE1 COMPLETED 2021-06-04 Orange County Research Institu... More >>te, Anaheim, California, 92801, United States|Riverside Clinical Research, Edgewater, Florida, 32132, United States|Clinical Pharmacology of Miami, Miami, Florida, 33014, United States|Orlando Clinical Research Center, Orlando, Florida, 32809, United States|Prism Research, Saint Paul, Minnesota, 55114, United States Less <<
NCT06190691 Healthy|Hepatic Insufficiency PHASE1 COMPLETED 2021-12-30 Orange County Research Institu... More >>te, Anaheim, California, 92801, United States|Orange County Research Center, Tustin, California, 92780, United States|Riverside Clinical Research, Edgewater, Florida, 32132, United States|Clinical Pharmacology of Miami, Miami, Florida, 33014, United States|Advanced Pharma Clinical Research, Miami, Florida, 33147, United States|Orlando Clinical Research Center, Orlando, Florida, 32809, United States|The Texas Liver Institute, San Antonio, Texas, 78215, United States|Pinnacle Clinical Research, San Antonio, Texas, 78229, United States Less <<
NCT06588478 Chronic Lymphocytic Leukemia|S... More >>mall Lymphocytic Lymphoma Less << PHASE2 RECRUITING 2025-12-28 Ironwood Cancer & Research Cen... More >>ters, Chandler, Arizona, 85224, United States|City of Hope National Medical Center, Duarte, California, 91010, United States|City of Hope National Medical Center, Irvine, California, 92618, United States|Palo Alto Medical Foundation Research Institute (PAMFRI), Palo Alto, California, 94304, United States|Stanford Cancer Center, Palo Alto, California, 94304, United States|Rocky Mountain Cancer Center, Aurora, Colorado, 80012, United States|University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida, 33136, United States|Mission Cancer + Blood, Des Moines, Iowa, 50309, United States|Saint Elizabeth Medical Center Edgewood, Edgewood, Kentucky, 41017, United States|American Oncology Partners of Maryland, PA, Bethesda, Maryland, 20817, United States|Boston Medical Center, Boston, Massachusetts, 02118, United States|Gulfport Memorial Hospital, Gulfport, Mississippi, 39501, United States|Clinical Research Alliance, Westbury, New York, 11590, United States|East Carolina University, Greenville, North Carolina, 27834, United States|Williamette Valley Cancer Institute & Research Center, Eugene, Oregon, 97401, United States|Cancer Care Associates Of York, York, Pennsylvania, 17403, United States|The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee, 38138, United States|Sarah Cannon Research Institute/SCRI, Nashville, Tennessee, 37203, United States|USO-Texas Oncology-Central/South Texas, Austin, Texas, 78705, United States|USO-Virginia Oncology Associates, Hampton, Virginia, 23666, United States|USO-Northwest Cancer Specialists, PC, Vancouver, Washington, 98683, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Bankstown-Lidcombe Hospital, Bankstown, New South Wales, 2200, Australia|Coffs Harbour Health Campus, Coffs Harbour, New South Wales, 2450, Australia|Calvary Mater Newcastle, Waratah, New South Wales, 2298, Australia|Princess Alexandra Hospital, Woolloongabba, Queensland, 4102, Australia|ICON Cancer Centre - Kurralta Park, Kurralta Park, South Australia, 5037, Australia|Royal Hobart Hospital, Hobart, Tasmania, 7000, Australia|Box Hill Hospital, Box Hill, Victoria, 3128, Australia|Latrobe Regional Health, Traralgon, Victoria, 3844, Australia|The Perth Blood Institute - West Perth, West Perth, Western Australia, 6005, Australia|Clinique Saint Pierre, Ottignies, Brabant Wallon, 1340, Belgium|Institut Jules Bordet, Anderlecht, Bruxelles-Capitale, Région De, 1070, Belgium|Groupe Jolimont, La Louvière, Hainaut, 7100, Belgium|CHR Verviers - La Tourelle, Verviers, Liège, 4800, Belgium|UZ Gent, Gent, Oost-Vlaanderen, 9000, Belgium|AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, B-9100, Belgium|UZ Leuven, Leuven, Vlaams-Brabant, 3000, Belgium|AZ Sint-Jan Brugge-Oostende AV, Brugge, West-Vlaanderen, 8000, Belgium|AZ Delta vzw, Roeselare, West-Vlaanderen, 8800, Belgium|Royal Victoria Regional Health Centre, Barrie, Ontario, L4M 6M2, Canada|CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec, G7H 5H6, Canada|Saskatoon Cancer Centre, Saskatoon, Saskatchewan, S7N4H4, Canada|Fakultní nemocnice Brno Bohunice, Brno, Brno-město, 625 00, Czechia|Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové, 500 05, Czechia|Fakultni nemocnice Kralovske Vinohrady, PRague, Praha 10, 100 34, Czechia|Vseobecna fakultni nemocnice v Praze, Praha 2, 12808, Czechia|Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland, 8200, Denmark|Roskilde Sygehus, Roskilde, Sj?lland, 4000, Denmark|Odense Universitetshospital, Odense, Syddanmark, 5000, Denmark|Centre Antoine-Lacassagne, Nice, Alpes-Maritimes, 06189, France|Groupe Hospitalier de la Région de Mulhouse et Sud Alsace - H?pital Emile Muller, Mulhouse, Alsace, 68100, France|Centre Hospitalier Universitaire de Caen - H?pital C?te de Nacre, Caen, Calvados, 14033, France|Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Haute-Garonne, 31059, France|Centre Hospitalier Régional Universitaire de Tours - H?pital Bretonneau, Tours, Indre-et-Loire, 37044 Cedex 9, France|Centre Hospitalier du Mans, Le Mans, Sarthe, 72000, France|Centre Hospitalier d'Argenteuil Victor Dupouy, Argenteuil, Val-d'Oise, 95107, France|Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Bayern, 63739, Germany|Centrum für H?matologie und Onkologie Bethanien, Frankfurt, Hessen, 60389, Germany|OSP G?ttingen, Goettingen, Niedersachsen, 37073, Germany|Onkologisches Ambulanzzentrum Hannover, Hannover, Niedersachsen, 30171, Germany|Gemeinschaftspraxis für H?matologie und Onkologie Münster, Münster, Nordrhein-Westfalen, 48153, Germany|InVO Institut für Versorgungsforschung in der Onkologie, Koblenz, Rheinland-Pfalz, 56068, Germany|Evangelismos General Hospital of Athens, Athens, Attikí, 106 76, Greece|Attikon General University Hospital, Chaidari, Attikí, 12462, Greece|General Hospital of Athens "Laiko", Αthens, Attikí, 11527, Greece|G. Papanikolaou General Hospital, Thessaloniki, Thessaloníki, 570 10, Greece|Pécsi Tudományegyetem Klinikai K?zpont, Pécs, Baranya, 7624, Hungary|Szegedi Tudományegyetem Szent-Gy?rgyi Albert Klinikai K?zpont, Szeged, Csongrád, 6725, Hungary|Semmelweis University, Budapest, 1088, Hungary|Dél-Pesti Centrumkórház, Budapest, 1097, Hungary|Azienda Ospedaliero Universitaria S.Anna, Cona, Emilia-Romagna, 44124, Italy|Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma, Lazio, 00168, Italy|ASST Grande Ospedale Metropolitano Niguarda, Milan, Lombardia, 20162, Italy|A.O.U.C. Policlinico di Bari, Bari, Puglia, 70124, Italy|Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO, Palermo, Sicilia, 90146, Italy|Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana, 50134, Italy|AO Santa Maria della Misericordia, Perugia, Umbria, 06132, Italy|Azienda Ospedale - Università Padova, Padova, Veneto, 35128, Italy|Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, 28100, Italy|AOU Policlinico Umberto I, Roma, 00161, Italy|Chonnam National University Hwasun Hospital, Hwasun-gun, Jeonranamdo, 58128, Korea, Republic of|Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul], 03080, Korea, Republic of|Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul], 03722, Korea, Republic of|Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul], 06351, Korea, Republic of|The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul], 06591, Korea, Republic of|The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul], 07345, Korea, Republic of|Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroc?awiu, Wroc?aw, Dolno?l?skie, 50-367, Poland|Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy, Bydgoszcz, Kujawsko-pomorskie, 85-168, Poland|Pratia MCM Krakow, Kraków, Ma?opolskie, 30-727, Poland|AIDPORT Sp. z o.o., Skórzewo, Wielkopolskie, 60-185, Poland|Pratia Onkologia Katowice, Katowice, ?l?skie, 40-519, Poland|Fundeni Clinical Institute, Bucuresti, Bucure?ti, 022328, Romania|Ovidius Clinical Hospital OCH, Ovidiu, Constan?a, 905900, Romania|Spitalul Clinic Municipal Filantropia Craiova, Craiova, Dolj, 200143, Romania|Spitalul Clinic Col?ea, Bucure?ti, 030171, Romania|Institutul Oncologic Cluj, Cluj, 400015, Romania|Institutul Regional de Oncologie, Ia?i, 700483, Romania|Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banska Bystrica, Banskobystricky Kraj, 975 17, Slovakia|Narodny onkologicky ustav, Bratislava, Bratislavsky Kraj, 833 10, Slovakia|Univerzitna Nemocnica L. Pasteura Kosice, Kosice, Ko?icky Kraj, 040 11, Slovakia|Univerzitna nemocnica Martin, Martin, ?ilinsky Kraj, 036 59, Slovakia|Hospital Universitario Virgen Macarena, Sevilla, Andalucía, 41009, Spain|Hospital Universitario Central de Asturias, Oviedo, Asturias, 33011, Spain|Institut Català d'Oncologia (ICO) - Badalona, Badalona, Barcelona [Barcelona], 08916, Spain|Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona], 08035, Spain|Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat, Barcelona [Barcelona], 08908, Spain|Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, 39008, Spain|Hospital Clínic de Barcelona, Barcelona, Catalunya [Catalu?a], 08036, Spain|Clinica Universidad de Navarra, Madrid, Madrid, Comunidad De, 28027, Spain|Hospital Universitario Infanta Leonor, Madrid, Madrid, Comunidad De, 28031, Spain|MD Anderson Cancer Center, Madrid, Madrid, Comunidad De, 28033, Spain|Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De, 28034, Spain|Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De, 28222, Spain|Hospital Costa del Sol, Marbella, Málaga, 29603, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Universitario Quironsalud Madrid, Madrid, 28223, Spain|Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, 37007, Spain|Hospital Universitario Virgen Del Rocio, Sevilla, 41013, Spain|Kocaeli üniversitesi, Izmit, Kocaeli, 41380, Turkey|Sakarya University School of Medicine, Adapazar?, Sakarya, 54100, Turkey|Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arast?rma Hastanesi, Ankara, 06200, Turkey|Ankara University Health Practice and Research Hospitals, Ankara, 06620, Turkey|Memorial Antalya Hospital, Antalya, 07090, Turkey|Yeditepe üniversitesi Ko?uyolu Hastanesi, Istanbul, 34718, Turkey|Ege Universitesi Hastanesi, Izmir, 35100, Turkey|VM Medical Park Mersin Hastanesi, Mersin, 33200, Turkey|Ondokuz May?s Universitesi, Samsun, 55139, Turkey|Maidstone Hospital, Maidstone, Kent, ME16 9QQ, United Kingdom|Lincoln County Hospital, Lincoln, Lincolnshire, LN2 5QY, United Kingdom|Northwick Park Hospital, Harrow, London, City Of, HA1 3UJ, United Kingdom|Hammersmith Hospital, London, London, City Of, W12 0HS, United Kingdom|Heartlands Hospital, Birmingham, B9 5SS, United Kingdom|The Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, United Kingdom|St James's University Hospital, Leeds, LS9 7TF, United Kingdom|Clatterbridge Cancer Centre - Liverpool, Liverpool, L7 8YA, United Kingdom|Singleton Hospital, Swansea, SA2 8QA, United Kingdom Less <<
NCT06181006 Healthy PHASE1 COMPLETED 2020-12-01 Covance Clinical Research Unit... More >>, Daytona Beach, Florida, 32117, United States Less <<
NCT06812715 Chronic Lymphocytic Leukemia PHASE2 NOT_YET_RECRUITING 2025-05-31 Peter MacCallum Cancer Centre,... More >> Melbourne, Victoria, 3000, Australia|Alfred Hospital, Melbourne, Victoria, 3004, Australia|Monash Medical Centre, Melbourne, Victoria, 3168, Australia Less <<
NCT06180980 Healthy PHASE1 COMPLETED 2021-03-08 Covance Clinical Research Unit... More >>, Daytona Beach, Florida, 32117, United States Less <<
NCT06258174 Healthy PHASE1 COMPLETED 2021-12-22 Labcorp Drug Development, Dall... More >>as, Texas, 75247, United States Less <<
NCT04849416 Leukemia, Lymphoid|Lymphoma, N... More >>on-Hodgkin|Lymphoma, Mantle-Cell|Lymphoma, Large B-Cell, Diffuse|Lymphoma, B-Cell|Lymphoma, B-Cell, Marginal Zone|Leukemia, Lymphocytic, Chronic, B-Cell Less << PHASE2 ACTIVE_NOT_RECRUITING 2025-04-25 Wannan Medical College Yijisha... More >>n Hospital, Wuhu, Anhui, 241001, China|Beijing Cancer hospital, Beijing, Beijing, 100142, China|Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, 510515, China|Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 511400, China|Hainan General Hospital, Haikou, Hainan, 570311, China|Affiliated Hospital of Hebei University, Baoding, Hebei, 71066, China|Xingtai People's Hospital, Xingtai, Hebei, 054031, China|Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, China|The First Affiliated Hospital of Henan University of Science &Technology, Luoyang Shi, Henan, 471003, China|Henan Cancer Hospital, Zhengzhou, Henan, 450008, China|Xiangya Hospital Central South University, Changsha, Hunan, 410008, China|Hunan Cancer Hospital, Changsha, Hunan, 410013, China|Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210000, China|The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215066, China|The First Hospital of Jilin University, Changchun, Jilin, 130021, China|Xi'an International Medical Center Hospital, Xi'an, Shaanxi, 710126, China|Sichuan Cancer Hospital, Chengdu, Sichuan, 610041, China|Institute of hematology&blood disease hospital, Tianjin, Tianjin, 300020, China|Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin, 300060, China|Xinjiang Medical University Cancer Hospital - Urumqi, Urumqi, Xinjiang, 830000, China|Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China|Shanghai East Hospital, Shanghai, 200120, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.43mL

2.09mL

1.04mL

20.86mL

4.17mL

2.09mL

References

 

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