Home Cart Sign in  
Chemical Structure| 374703-78-3 Chemical Structure| 374703-78-3

Structure of PKG drug G1
CAS No.: 374703-78-3

Chemical Structure| 374703-78-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

PKG Drug G1 targets C42 of PKG Iα. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of PKG drug G1

CAS No. :374703-78-3
Formula : C13H11N3OS
M.W : 257.31
SMILES Code : O=C(/C(N1)=C/C2=C(C)NC3=C2C=CC=C3)NC1=S
MDL No. :N/A

Safety of PKG drug G1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Rat aortic smooth muscle cells 10 or 50 mM 10 minutes To evaluate the effect of G1 on VASP phosphorylation. G1 alone did not alter VASP phosphorylation but synergistically enhanced it when co-administered with 8-Br-cGMP. Hypertension. 2017 Sep;70(3):577-586

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Angiotensin II-induced hypertension model Intraperitoneal or oral 3.7–14.8 mg/kg (intraperitoneal) or 20 mg/kg (oral) Single dose or continuous administration for 4 days To evaluate the antihypertensive effect of G1 in a hypertension model. G1 effectively lowered blood pressure in WT mice but had no effect in C42S PKG Iα knock-in mice. Hypertension. 2017 Sep;70(3):577-586

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.89mL

0.78mL

0.39mL

19.43mL

3.89mL

1.94mL

38.86mL

7.77mL

3.89mL

 

Historical Records

Categories